Screening 16 bisphenol analogues in asthenospermia: BPM-CDK1 axis identified by computational and In Vitro validation [0.03%]
筛选16种双酚类似物用于治疗弱精症：通过计算和体外验证鉴定BPM-CDC2激酶1轴
Siqing Hu,Ling Ding,Yiwei Zhao et al.
Siqing Hu et al.
Bisphenol A (BPA) is a ubiquitous industrial chemical found in numerous consumer products. While its endocrine-disrupting effects and reproductive toxicity are well-documented, the widespread use of structural analogues (BPs) as "BPA-free" ...
Assessment of Mycotoxin Exposure in Women Undergoing Assisted Reproduction: A Study of Urinary Biomarkers Related to Oocyte and Embryo Development [0.03%]
基于卵子和胚胎发育的尿液生物标志物评估辅助生育人群真菌毒素暴露风险的研究
Antonella Mastrorocco,Michele Spinelli,Nicola Antonio Martino et al.
Antonella Mastrorocco et al.
Mycotoxins are widespread food contaminants, and urinary biomarkers reflect recent dietary exposure. Although mycotoxins have been implicated in reproductive toxicity, their impact on human oocyte and embryo development remains poorly chara...
Corrigendum to "Trifluoroacetic acid and ocular malformations in rabbits: Proposed mechanisms of action" [Reprod. Toxicol. 143 (2026) 109258] [0.03%]
关于“三氟乙酸和兔眼畸形：作用机制的研究”一文的勘误(《生殖毒理学》第143卷(2026年)109258号论文)
Julian French,Jason Manton,Maaike E Schutte et al.
Julian French et al.
Reproductive toxicity and transgenerational effects of microplastics: Evidence from experimental models and underlying epigenetic mechanisms [0.03%]
微塑料的生殖毒性和跨世代效应：来自实验模型和表观遗传机制的证据
Shuyao Qiu,Shuoyang Zhao,Haichang Diao et al.
Shuyao Qiu et al.
Micro- and nanoplastics (MNPs) are emerging environmental contaminants with ubiquitous distribution and growing concern for reproductive health. Recent detection of MNPs in human follicular fluid and seminal plasma suggests that these parti...
The Effect of Long-term Oral Tamoxifen and Metabolism in the Mouse Ovary [0.03%]
长期口服他莫昔芬对小鼠卵巢的影响及作用机制研究进展
Lynda K McGinnis,Xiaohui Yu,Michael S Awadalla et al.
Lynda K McGinnis et al.
Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) widely used as long-term chemotherapy for premenopausal women with estrogen-sensitive breast cancer. We developed a murine model of chronic TAM exposure by administering TAM ...
Atomoxetine hydrochloride impairs human sperm quality and function via disruption of calcium homeostasis and PKC signaling: A combined network pharmacology and in vitro study [0.03%]
盐酸阿托莫西汀通过干扰钙稳态和蛋白激酶C信号通路损害人类精子质量和功能：一种结合网络药理学和体外实验的方法
Xuchang Liu,Shiyao Weng,Xia Zhong et al.
Xuchang Liu et al.
Atomoxetine Hydrochloride (ATX) is a widely prescribed first-line pharmacotherapy for adult attention deficit hyperactivity disorder (ADHD). Despite its chronic use among men of reproductive age, the potential impact of ATX on male fertilit...
FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: cytotoxicity, oxidative stress, steroidogenesis, cell senescence and expression of related key developmental genes [0.03%]
邻苯二甲酸二丁酯通过卵泡刺激素介导的内分泌干扰对绵羊卵巢颗粒细胞毒性、氧化应激、类固醇生成、细胞衰老及关键发育基因表达的影响
Poonam Singh,Bogapathi Sampath Kumar,Sumanta Nandi et al.
Poonam Singh et al.
Di-n-butyl phthalate (DBP) is a widely used phthalate ester recognized for its endocrine-disrupting properties and potential reproductive toxicity. The present study aimed to evaluate the concentration-dependent effects of DBP on morphology...
Empagliflozin and naringenin mitigate cisplatin-induced testicular injury via modulating NLRP3 inflammasome-mediated pyroptosis: Integrated molecular docking and in vivo evidence [0.03%]
艾格列净和芸苔素通过调节NLRP3炎症小体介导的细胞焦亡减轻顺铂诱导的睾丸损伤：分子对接及体内证据
Sayed Mahmoud,Rasha H Abdel-Ghany,Atef S Elgharbawy et al.
Sayed Mahmoud et al.
Background: Cisplatin (CP) is a potent anticancer drug; however, its medical use is constrained by multiple organ toxicity. CP-induced testicular injury is mainly driven by oxidative stress and inflammation. ...
Statistical and Experimental Approaches to Discriminate Between Substance-specific Reproductive Effects and Those Mediated by Maternal Undernutrition - a Case Study with Rosin and Derivatives [0.03%]
基于松香及其衍生物的案例研究，用于区分物质特异性生殖效应和由母体营养不良介导的效应的统计学方法与实验方法
Theo Le Godec,Larry G Higgins,Mike G Penman et al.
Theo Le Godec et al.
It is well-accepted that undernutrition lowers fertility of rodents and retards growth of their offspring. However, accounting for undernutrition's confounding effects in reproductive toxicology studies remains challenging. Rosin (EC 232-47...
Trifluoroacetic acid and ocular malformations in rabbits: Proposed mechanisms of action [0.03%]
三氟乙酸与兔眼畸形：作用机制探讨
Julian French,Jason Manton,Maaike E Schutte et al.
Julian French et al.
Administration of high oral doses of sodium trifluoroacetate (NaTFA) to rabbits during pregnancy led to excessively high trifluoroacetic acid (TFAA) body burden after repeated gavage application. This resulted in rare but apparently reprodu...