Metabolic Syndrome Is Associated with Increased Plasma Fibroblast Growth Factor 21 (FGF21) in Postmenopausal Breast Cancer Survivors: Implications for Therapy and Diagnosis [0.03%]
代谢综合征与绝经后乳腺癌幸存者的血浆成纤维细胞生长因子21（FGF21）升高有关：对治疗和诊断的意义
Pedro Céspedes,Cristina Buigues,María Dolores Torregrosa et al.
Pedro Céspedes et al.
Background: Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several organs and regulates energy homeostasis, including reducing fat mass and lowering hyperglycemia, insulin resistance and d...
Astrocytoma-Specific Prognostic Associations of Amyloid-Related Biological Processes [0.03%]
与淀粉样蛋白相关的生物学过程具有星形胶质细胞瘤特异性的预后相关性
Felix Y Narvaez Irizarry,Tyrel R Porter,Neisha Ramirez Serrano et al.
Felix Y Narvaez Irizarry et al.
Background: Amyloid-related pathways are well studied in neurodegenerative diseases but remain poorly characterized in gliomas. Amyloid-related transcriptional programs in low-grade gliomas (astrocytoma grade II-III) and oligodendrogliomas,...
High uPAR and Low miR-221 Expression Predict Poor Disease-Free Survival in Triple-Negative Breast Cancer [0.03%]
高uPAR和低miR-221表达预示三阴性乳腺癌患者较差的无病生存期
Weiwei Gong,Yueyang Liu,Natalie Falkenberg et al.
Weiwei Gong et al.
Background: Triple-negative breast cancer (TNBC) is associated with poor prognosis and limited targeted treatment options. The urokinase plasminogen activator receptor (uPAR) contributes to tumor aggressiveness and may be...
Real-Time Single-Cell Measurement and Kinetic Modeling of Daunorubicin Uptake in Multidrug-Resistant Leukemia Cells Using a Microfluidic Biochip [0.03%]
基于微流控芯片的单细胞水平药代动力学研究多药耐药白血病细胞达卡巴嗪实时摄取监测及建模分析
Yuchun Chen,Megan Chiem,Nandini Joshi et al.
Yuchun Chen et al.
Background/Objectives: Multidrug resistance (MDR) remains a major pathophysiological barrier to effective chemotherapy based on anthracyclines, including daunorubicin (DNR), in the treatment of leukemia. However, conventional population-lev...
Hypovolemic Shock in the Setting of Third Spacing with Concentric Left Ventricular Hypertrophy: A Physiology-Guided Management of Fluid Resuscitation-Case Report and Literature Review [0.03%]
第三间隙伴心室同心肥厚的低血容量性休克：基于生理学的液体复苏治疗管理-病例报告和文献回顾
Akram M Eraky,Yasser Mokhtar,Guy Grabau et al.
Akram M Eraky et al.
Patients with preload-dependent conditions are at high risk of hemodynamic instability from both hypovolemia and hypervolemia. In hypovolemic states, the presence of third spacing may be misleading and obscure true intravascular volume stat...
Transient Glycocalyx Remodeling by Intravenous Hyaluronidase in Atherosclerosis: A Hypothesis-Generating Review [0.03%]
关于动脉粥样硬化中静脉注射透明质酸酶引起瞬时糖萼重塑的假说生成性综述
Andreas Pfützner,Tobias Gantner,Harald Burgard et al.
Andreas Pfützner et al.
Atherosclerosis remains the leading cause of death worldwide and imposes a major healthcare burden. Physiologically, elimination of cholesterol from the arterial wall depends on reverse cholesterol transport (RCT). RCT requires access to HD...
Towards Global HPV Eradication: Single-Dose HPV Vaccination vs. Pseudoscience [0.03%]
走向全球消除HPV：单剂型HPV疫苗 vs 假科学
Reona Shiro,Ikuo Tsunoda
Reona Shiro
Human papillomavirus (HPV) can cause cervical cancer. Global viral eradication relies on specific criteria, including a single host species and effective vaccines, a feat successfully achieved with smallpox and rinderpest. Although measles ...
Redefining Obstructive Sleep Apnea: Multidimensional Phenotyping Beyond the Apnea-Hypopnea Index [0.03%]
重新定义阻塞性睡眠呼吸暂停：超出呼吸暂停低通气指数的多维度分型
Harjinder Singh,Nida Qadir,Malti Bhamrah et al.
Harjinder Singh et al.
Background: Obstructive sleep apnea (OSA) is a complex and diverse disorder affecting almost one billion individuals worldwide. Severity of untreated OSA, measured by the apnea-hypopnea index (AHI), is noted to be associated with an increas...
Early Motor Development and Rehabilitation Outcomes in Apert Syndrome: Gross Motor Function Measures-Case Report [0.03%]
阿佩尔特综合征的早期运动发育和康复结局：粗大运动功能量表-病例报告
Lorena Oreščanin,Zrinka Biloglav,Ivana Škrlec
Lorena Oreščanin
Introduction: Apert syndrome is a rare genetic disorder characterized by craniofacial anomalies and limb malformations, often accompanied by neurodevelopmental abnormalities that can considerably affect motor development....
Association of Sex, Age, and Inflammatory Cell Counts with Complicated Acute Appendicitis [0.03%]
年龄、性别和炎症细胞计数与复杂性急性阑尾炎的关系
Said José Serrano Guzmán,Carlos Leyber Vargas Juárez,Marcos Hernández Gómez et al.
Said José Serrano Guzmán et al.
Background/objectives: Sex and age influence inflammatory responses, but researchers have not fully characterized their combined association with complicated acute appendicitis (CAA). This study assessed the independent a...