Revisiting Atopy: The IgE-Dependent Amplification Loop as a Forgotten Driver of Atopic Dermatitis [0.03%]
重访特应症：IgE依赖性放大环路是被遗忘的特应性皮炎驱动因素
Ryoji Tanei,Yasuko Hasegawa
Ryoji Tanei
Atopic dermatitis (AD) is increasingly interpreted through frameworks emphasizing barrier dysfunction, type 2 cytokine signaling, pruritus pathways, and microbial dysbiosis, often relegating IgE-mediated mechanisms to secondary roles. In th...
Pulmonary Squamous Cell Carcinoma Dissemination Through Air Spaces (STAS): Clinicopathologic Findings in Different Tumor Origins [0.03%]
肺鳞状细胞癌通过气腔播散（STAS）的临床病理特点及不同肿瘤起源分布
Bianca Herrmann,Horia Sirbu,Hayk Kikoyan et al.
Bianca Herrmann et al.
Background: Spread through air spaces (STAS) is a recognized histologic pattern of invasion associated with poor prognosis in non-small-cell lung cancer (NSCLC), particularly adenocarcinoma. However, its presence in pulmonary squamous cell ...
Oxidative and Nitrosative Stress in Atopic Dermatitis and Depression: Similarities in Biomarkers and Pathophysiological Mechanisms [0.03%]
特应性皮炎和抑郁症中的氧化及一氧化氮应激：生物标志物及病理生理机制的相似性
Dominika Jabłonka,Stefan Modzelewski,Napoleon Waszkiewicz
Dominika Jabłonka
Background: Atopic dermatitis is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation, whereas major depressive disorder is a common psychiatric condition with a subs...
NG2 Glia and Cellular Crosstalk in Health and Disease: Focus on Spinal Cord Injury [0.03%]
少突胶质前体细胞和细胞通讯在健康与疾病中的作用：以脊髓损伤为例
Ilyas Kabdesh,Aizilya Bilalova,Yana Mukhamedshina et al.
Ilyas Kabdesh et al.
NG2 glia, also known as oligodendrocyte progenitor cells, represent a unique population of glial cells characterized by dynamic morphology and the ability to extend branched processes that actively contact neurons and other cellular element...
Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster [0.03%]
叙利亚金仓鼠遗传性心肌病胚胎发育中的细胞内离子重构
Ghassan Bkaily,Alexandre Normand,Ashley Jazzar et al.
Ghassan Bkaily et al.
Background/objectives: The development of hereditary cardiomyopathy associated with early death was known to take place during the patients' lifetime. Previous work showed that remodeling of heart cells in hereditary card...
From Glycocalyx Shedding to Microvascular Collapse in Sepsis: Endothelial Pathophysiology, Organ Dysfunction, and Mechanistic Biomarkers [0.03%]
从感染性休克的糖萼脱落至微血管崩溃：内皮细胞病理生理、脏器功能障碍及机制生物标志物
Jhan S Saavedra-Torres,Lady Viviana Acosta Castillo,Alexandra Montoya Rendon et al.
Jhan S Saavedra-Torres et al.
Sepsis is a systemic disorder in which infection-induced inflammation progressively disrupts vascular homeostasis and drives organ dysfunction. This review reframes septic pathophysiology as a sequential and self-amplifying process centered...
Mechanistic Insights into the Role of Artificial Intelligence and Machine Learning in the Diagnosis and Management of Multiple Sclerosis [0.03%]
人工智能和机器学习在诊断和管理多发性硬化症中的作用机制见解
Alireza Minagar,Mohammadali Sahraian
Alireza Minagar
Multiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system whose heterogeneous clinical, radiological, and biological course has long resisted precise individual-level prediction. The recent co...
Nasal Cytology as a Local Biomarker of Airway Inflammation: A Paradigm Shift in Precision Medicine [0.03%]
鼻腔细胞学作为气道炎症局部生物标志物的范式转变在精准医学中的应用研究
Matteo Gelardi
Matteo Gelardi
Biomarker-driven approaches have markedly improved the stratification and management of airway inflammatory diseases. However, in everyday clinical practice, these strategies still rely mainly on systemic indicators, which often provide onl...
Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation [0.03%]
左心发育不全综合征的统一病因是什么？评估疾病发生的遗传、结构和血流动力学模型
Reese Leonhard,Zachary Beau Phillips,Jamie Wilson et al.
Reese Leonhard et al.
Background: Hypoplastic left heart syndrome (HLHS) is defined as "a spectrum of congenital cardiovascular malformations with normally aligned great arteries without a common atrioventricular junction, characterized by underdevelopment of th...
Pantothenic Acid Derivatives Modulate Oxidative Stress and Hepatic Fibrosis in Bile Duct Ligation-Induced Cholestatic Liver Injury [0.03%]
泛酸衍生物调节胆管结扎诱导的胆汁淤积性肝损伤中的氧化应激和肝纤维化
Dmitry S Semenovich,Polina A Abramicheva,Ljubava D Zorova et al.
Dmitry S Semenovich et al.
Background/objectives: Inflammation and oxidative stress are key factors contributing to the initiation and progression of liver fibrosis in chronic obstructive cholestasis. Pantothenic acid (PA) and some of its derivativ...