Evaluation of the effects of simulated hypoxia by CoCl2 on radioresistance and change of hypoxia-inducible factors in human glioblastoma U87 tumor cell line [0.03%]
CoCl2模拟低氧状态下人胶质母细胞瘤U87肿瘤细胞系放射耐受性及缺氧诱导因子变化的评价研究
Elham Khakshour,Mohammad Taghi Bahreyni-Toossi,Kazem Anvari et al.
Elham Khakshour et al.
Purpose: Glioblastoma (GBM) is considered the most common and lethal type of brain tumor with a poor prognosis. GBM treatment has challenges due to its aggressive nature, which often causes treatment failure and recurrenc...
A positive correlation between mutated gene of sickle cell anemia and glucose-6-phosphate dehydrogenase among gond tribes of Chhattisgarh, India [0.03%]
印度恰蒂斯加尔邦Gond部落中镰状细胞贫血症突变基因与葡萄糖-6-磷酸脱氢酶之间的正相关性研究
Ekta Singh,Lohit Raj Shivwanshi,Anil Kumar
Ekta Singh
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy affecting millions of individuals worldwide. It is believed that the prevalence of G6PD deficiency in different ethnic populat...
Higher TP53 somatic mutation prevalence from liquid biopsy analysis in ever smoker non-small-cell lung cancer patients [0.03%]
基于液体活检分析的吸烟肺癌患者中较高的TP53体细胞突变发生率
Haktan Bağış Erdem,Mustafa Tarık Alay,Zeynep Özdemir et al.
Haktan Bağış Erdem et al.
Objective: Cigarette smoking is a primary risk factor, linked to 80% of LC deaths. TP53, a key gene, is implicated in various cancers, with TP53 alterations in 36.7% of cancers. This research aims to investigate TP53 muta...
Variants in exon 2 of MED12 gene causes uterine leiomyoma's through over-expression of MMP-9 of ECM pathway [0.03%]
MED12基因外显子2的变异通过ECM途径中基质金属蛋白酶9表达过多导致子宫肌瘤生成
Vivek Pandey,Priyanka Jain,Souradip Chatterjee et al.
Vivek Pandey et al.
Aims: To study the impact of Mediator complex subunit 12 (MED12) gene variants on the encoded protein's function and pathogenic relevance for genesis of uterine leiomyoma's (ULs). ...
The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis [0.03%]
DNA聚合酶eta精确绕过嘧啶二聚体对紫外线诱导突变的贡献
C F M Menck,R S Galhardo,A Quinet
C F M Menck
Human xeroderma pigmentosum variant (XP-V) patients are mutated in the POLH gene, responsible for encoding the translesion synthesis (TLS) DNA polymerase eta (Pol eta). These patients suffer from a high frequency of skin tumors. Despite sev...
The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway [0.03%]
E2F1/MELTF轴通过调节 notch信号通路促进肺腺癌进展
Lidan Zhang,Lei Shi
Lidan Zhang
Background: Lung adenocarcinoma (LUAD) represents the predominant subtype of lung cancer. MELTF, an oncogene, exhibits high expression in various cancer tissues. Nevertheless, the precise role of MELTF in the progression ...
Analysis of chemical structures and mutations detected by Salmonella TA98 and TA100 [0.03%]
沙门氏菌TA98和TA100检出的化学结构及突变分析
Kevin P Cross,David M DeMarini
Kevin P Cross
As part of an analysis performed under the auspices of the International Workshop on Genotoxicity Testing (IWGT) in 2017, we and others showed that Salmonella frameshift strain TA98 and base-substitution strain TA100 together + /- S9 detect...
DinB (DNA polymerase IV), ImuBC and RpoS contribute to the generation of ciprofloxacin-resistance mutations in Pseudomonas aeruginosa [0.03%]
DinB(DNA聚合酶IV)、ImuBC和RpoS参与产生铜绿假单胞菌的环丙沙星耐药突变
Declan Fahey,James O&#x;Brien,Joanne Pagnon et al.
Declan Fahey et al.
We investigated the role(s) of the damage-inducible SOS response dinB and imuBC gene products in the generation of ciprofloxacin-resistance mutations in the important human opportunistic bacterial pathogen, Pseudomonas aeruginosa. We found ...
Lethal and mutagenic effects of different LET radiations on Bacillus subtilis spores [0.03%]
不同LET辐射对枯草杆菌孢子致死及诱发突变效应的比较研究
Katsuya Satoh,Wataru Hoshino,Yoshihiro Hase et al.
Katsuya Satoh et al.
New, useful microorganism resources have been generated by ionizing radiation breeding technology. However, the mutagenic effects of ionizing radiation on microorganisms have not been systematically clarified. For a deeper understanding and...
Chronic treatment with ATR and CHK1 inhibitors does not substantially increase the mutational burden of human cells [0.03%]
ATR和CHK1抑制剂的长期治疗不会显著增加人类细胞的突变负担
Lisa Casimir,Samuel Zimmer,Félix Racine-Brassard et al.
Lisa Casimir et al.
DNA replication stress (RS) entails the frequent slow down and arrest of replication forks by a variety of conditions that hinder accurate and processive genome duplication. Elevated RS leads to genome instability, replication catastrophe a...