The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway [0.03%]
E2F1/MELTF轴通过调节 notch信号通路促进肺腺癌进展
Lidan Zhang,Lei Shi
Lidan Zhang
Background: Lung adenocarcinoma (LUAD) represents the predominant subtype of lung cancer. MELTF, an oncogene, exhibits high expression in various cancer tissues. Nevertheless, the precise role of MELTF in the progression ...
Analysis of chemical structures and mutations detected by Salmonella TA98 and TA100 [0.03%]
沙门氏菌TA98和TA100检出的化学结构及突变分析
Kevin P Cross,David M DeMarini
Kevin P Cross
As part of an analysis performed under the auspices of the International Workshop on Genotoxicity Testing (IWGT) in 2017, we and others showed that Salmonella frameshift strain TA98 and base-substitution strain TA100 together + /- S9 detect...
DinB (DNA polymerase IV), ImuBC and RpoS contribute to the generation of ciprofloxacin-resistance mutations in Pseudomonas aeruginosa [0.03%]
DinB(DNA聚合酶IV)、ImuBC和RpoS参与产生铜绿假单胞菌的环丙沙星耐药突变
Declan Fahey,James O&#x;Brien,Joanne Pagnon et al.
Declan Fahey et al.
We investigated the role(s) of the damage-inducible SOS response dinB and imuBC gene products in the generation of ciprofloxacin-resistance mutations in the important human opportunistic bacterial pathogen, Pseudomonas aeruginosa. We found ...
Lethal and mutagenic effects of different LET radiations on Bacillus subtilis spores [0.03%]
不同LET辐射对枯草杆菌孢子致死及诱发突变效应的比较研究
Katsuya Satoh,Wataru Hoshino,Yoshihiro Hase et al.
Katsuya Satoh et al.
New, useful microorganism resources have been generated by ionizing radiation breeding technology. However, the mutagenic effects of ionizing radiation on microorganisms have not been systematically clarified. For a deeper understanding and...
Chronic treatment with ATR and CHK1 inhibitors does not substantially increase the mutational burden of human cells [0.03%]
ATR和CHK1抑制剂的长期治疗不会显著增加人类细胞的突变负担
Lisa Casimir,Samuel Zimmer,Félix Racine-Brassard et al.
Lisa Casimir et al.
DNA replication stress (RS) entails the frequent slow down and arrest of replication forks by a variety of conditions that hinder accurate and processive genome duplication. Elevated RS leads to genome instability, replication catastrophe a...
LncRNA UCA1 could regulate the progression of neuropathic pain by regulating miR-135a-5p [0.03%]
长链非编码RNA UCA1通过调节miR-135a-5p参与神经病理性疼痛的发展
Bingbing Wu,Xiaogang Zhou
Bingbing Wu
Background: Neuropathic pain (NPP) is known as a common neurological disease with high incidence rate. The present work focused on the roles of long non-coding RNA urothelial carcinoma antigen 1(LncRNA UCA1) in NPP and th...
Hsa-miR-1269a up-regulation fosters the malignant progression of esophageal squamous cell carcinoma via targeting FAM46C [0.03%]
miR-1269a通过靶向FAM46C促进食管鳞癌恶性进展
Yuefeng Ma,Xin Xing,Chuantao Cheng et al.
Yuefeng Ma et al.
Esophageal squamous cell carcinoma (ESCC) is a malignancy of the alimentary tract resulting in death worldwide. The role and underlying mechanism of hsa-miR-1269a in the progression of ESCC remain unclear. In this study, hsa-miR-1269a was s...
Uncommon variants detected via hereditary cancer panel and suggestions for genetic counseling [0.03%]
罕见突变的检测及其遗传咨询建议
Zeynep Özdemir,Ezgi Çevik,Ömür Berna Çakmak Öksüzoğlu et al.
Zeynep Özdemir et al.
Objective: Hereditary cancer syndromes constitute 5-10% of all cancers. The development of next-generation sequencing technologies has made it possible to examine many hereditary cancer syndrome-causing genes in a single ...
Identification and validation of long noncoding RNA AC083900.1 and RP11-283C24.1 for prediction of progression of osteosarcoma [0.03%]
长链非编码RNA AC083900.1和RP11-283C24.1在预测骨肉瘤进展中的鉴定与验证
Liangkun Huang,Wenyi Jin,Yucheng Bao et al.
Liangkun Huang et al.
Background: The role of cuproptosis, an emerging cell death pathway that makes a remarkable contribution to tumor progression, remains elusive in osteosarcoma (OS), in addition to its regulator, including long-no-coding R...
Bioinformatics analysis to identify breast cancer-related potential targets and candidate small molecule drugs [0.03%]
乳腺癌相关潜在靶点及候选小分子药物的生物信息学分析
Huan Hong,Haifeng Chen,Junjie Zhao et al.
Huan Hong et al.
Objective: The purpose of this study is to identify potential targets associated with breast cancer and screen potential small molecule drugs using bioinformatics analysis. ...