The role of KIT mutations in oral melanoma and disease progression: A literature review on early detection and targeted therapy [0.03%]
KIT突变在口腔黑色素瘤中的作用及疾病进展：早期检测与靶向治疗的文献综述
Sai Priyankha,Dhanraj Ganapathy,Smitha Nair et al.
Sai Priyankha et al.
Oral melanoma is a rare and aggressive subtype of melanoma that presents significant challenges in terms of delayed diagnosis and treatment. One promising clinical outcome is the detection of KIT gene mutations, which play a key role in tum...
Mothers against decapentaplegic homolog 3-activated FAT atypical cadherin 2 regulates programmed death ligand-1 to mediate immune evasion in lung squamous cell carcinoma [0.03%]
母细胞乳头状瘤病毒活化蛋白3激活的非典型钙黏着蛋白FAT小肠上皮肿瘤同源物2调节程序性死亡配体1介导肺鳞癌免疫逃逸
Yuanqiang Zhang,Chunping Yang,Haowen Deng et al.
Yuanqiang Zhang et al.
Background: Lung squamous cell carcinoma (LUSC) represents a distinct subtype of lung cancer, diverging significantly from lung adenocarcinoma. It demonstrates the ability to evade the immune system before the tumor has e...
Potential targets and molecular mechanisms of curcumin in treating Laryngeal and Pharyngeal Carcinoma throat cancer based on network pharmacology and bioinformatics analysis [0.03%]
基于网络药理学和生物信息学分析的姜黄素治疗喉癌和咽癌的潜在靶点及分子机制
Jixiang Lei,Xianyun Tang,Yuanchao Lin et al.
Jixiang Lei et al.
Background: Curcumin exhibits significant antitumor activity, inhibiting proliferation, angiogenesis, invasion, and metastasis, highlighting its potential for cancer treatment. However, its mechanisms in Laryngeal and Pha...
Non-clonal interphase markers of chromosomal instability in malignancy acquisition and cancer progression [0.03%]
非克隆性间期染色体不稳定标志在恶性肿瘤获得和癌症进展中的作用
Vinícius Bernardo de Oliveira,João Marcos Oliveira-Silva,Giovanna De Souza Maciel et al.
Vinícius Bernardo de Oliveira et al.
Chromosomal instability (CIN) is a pervasive feature of cancer and a major driver of tumor heterogeneity, evolution, and therapeutic resistance. Arising predominantly from defects in chromosome segregation, DNA repair, and mitotic fidelity,...
miR-145-5p induces ferroptosis by targeting Notch2 to suppress melanoma progression [0.03%]
miR-145-5p通过靶向Notch2诱导铁死亡以抑制黑色素瘤进展
Xinghui Li,Yannan Jiang,Yanxia Ding et al.
Xinghui Li et al.
Background: Melanoma exhibits high malignancy with limited treatment options, while the newly defined type of programmed cell death, ferroptosis, presents a promising therapeutic avenue for melanoma. Notch2 has been impli...
Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications [0.03%]
遗传性癌症检测中RAD51C、RAD51D和BRIP1单等位基因变异的谱系：变异频谱及临床咨询意义
Zeynep Özdemir-Pehlivan,Afife Büke,Ezgi Çevik-Demir et al.
Zeynep Özdemir-Pehlivan et al.
Defects in homologous recombination repair genes contribute to hereditary cancer susceptibility beyond BRCA1 and BRCA2, yet clinical interpretation of intermediate-penetrance genes remains challenging. We retrospectively evaluated unrelated...
Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis [0.03%]
一种全面的在线分析方法预测TP53基因相关肝细胞癌生物标志物
Amna Saeed,Riffat Iqbal,Mohammad Rahim et al.
Amna Saeed et al.
TP53 mutation is one of the most frequently altered genetic variants leading to hepatocellular carcinoma (HCC). Single nucleotide polymorphisms (SNPs) in this gene play a crucial role in predicting the risk of HCC development. This study ai...
IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors [0.03%]
IDH1突变通过上调缺氧诱导因子1α促进胶质瘤血管生成
Muhammed Deniz Oksal,Turker Kilic,Timucin Avsar
Muhammed Deniz Oksal
Glial tumors are the most common malignant brain tumors, and IDH1 serves as an important diagnostic and prognostic molecular marker in gliomas. The mutation status of IDH1 influences prognosis, patient survival, and treatment response in gl...
Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling [0.03%]
靶向基因沉默介导的食管癌中过表达的致癌基因：来自结合亲和力和热力学分析的见解
Sabnam Nasrin Choudhury,Tarikul Huda Mazumder,Sahidul Saikia et al.
Sabnam Nasrin Choudhury et al.
Esophageal cancer (ESCA) ranks among the most lethal malignancies worldwide, with late-stage diagnosis, poor prognosis, and limited treatment options contributing to its high mortality. MicroRNAs (miRNAs), short non-coding RNAs with gene-si...
The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer [0.03%]
Polygonum cuspidatum中的活性成分芦丁通过靶向COL3A1增强CD8⁺ T细胞的杀伤作用从而抑制胃癌进展
Yunhai Wei,Huancen Guo,Wenjing Hu et al.
Yunhai Wei et al.
Background: Gastric cancer (GC) is a highly prevalent gastrointestinal malignancy with poor prognosis worldwide, and its initiation and progression are closely associated with tumor immune escape. Polygonum cuspidatum, a ...