High expression of TRIP13 is associated with tumor progression in H. pylori infection induced gastric cancer [0.03%]
TRIP13的高表达与幽门螺旋杆菌感染诱导的胃癌的肿瘤发展有关
Longxiang Wu,Qiu Xue,Xiaochun Xia
Longxiang Wu
Background/objective: H. pylori is a recognized bacterial carcinogen in the world to cause gastric cancer (GC). However, the molecular mechanism of H. pylori infection-induced GC is not completely clear. Thus, there is an...
Mechanisms of piperonyl butoxide cytotoxicity and its enhancement with imidacloprid and metals in Chinese hamster ovary cells [0.03%]
肉桂酸叔丁酯的细胞毒性及其与啶虫脒和金属在中华仓鼠卵巢细胞中的增效作用机制
Mai M Awad,Piyawan Chailapakul,Mark A Brown et al.
Mai M Awad et al.
The widespread use of chemicals and the presence of chemical and metal residues in various foods, beverages, and other consumables have raised concerns about the potential for enhanced toxicity. This study assessed the cytotoxic effects of ...
Allium cepa tests: Exploring bleomycin induced cyto-genotoxicity and altered cell cycle kinetics in root tips meristematic cells [0.03%]
洋葱测试：探究丝裂霉素诱导的根尖分生细胞的细胞遗传毒性和改变的细胞周期动力学
Ria Das,Sanjib Ray
Ria Das
Bleomycin, commonly employed in treating Hodgkin's lymphoma and testicular cancer, is associated with significant pulmonary toxicity. While various studies have assessed the toxic impact of chemotherapeutic agents on aquatic and terrestrial...
LINC00665 target let-7i/HMGA1 promotes the proliferation and invasion of hepatoma cells [0.03%]
LINC00665靶向let-7i/HMGA1促进肝癌细胞的增殖和侵袭
Bo-Chao Zhang,Si-Yuan Ma,Ping Zhu et al.
Bo-Chao Zhang et al.
Objectives: Our group previously found that LINC00665 was upregulated in hepatocellular carcinoma (HCC) tissues through database analysis; however, the potential molecular mechanism of LINC00665 in HCC progression still n...
Inducing mutation and ascertaining lethal dosage of in vitro cultures of banana cv. Ney Poovan to ethyl methane sulfonate [0.03%]
离体培养指天蕉对甲磺酸乙酯诱变及致死剂量测定的研究
C Y Shalini Udaya
C Y Shalini Udaya
In vitro mutation breeding in vegetatively propagated crops like banana offers a benefit in screening for beneficial variants in plant cells or cultured tissues. An attempt was made to induce mutants and determine the lethal dose, as it is ...
Evaluation of the effects of simulated hypoxia by CoCl2 on radioresistance and change of hypoxia-inducible factors in human glioblastoma U87 tumor cell line [0.03%]
CoCl2模拟低氧状态下人胶质母细胞瘤U87肿瘤细胞系放射耐受性及缺氧诱导因子变化的评价研究
Elham Khakshour,Mohammad Taghi Bahreyni-Toossi,Kazem Anvari et al.
Elham Khakshour et al.
Purpose: Glioblastoma (GBM) is considered the most common and lethal type of brain tumor with a poor prognosis. GBM treatment has challenges due to its aggressive nature, which often causes treatment failure and recurrenc...
A positive correlation between mutated gene of sickle cell anemia and glucose-6-phosphate dehydrogenase among gond tribes of Chhattisgarh, India [0.03%]
印度恰蒂斯加尔邦Gond部落中镰状细胞贫血症突变基因与葡萄糖-6-磷酸脱氢酶之间的正相关性研究
Ekta Singh,Lohit Raj Shivwanshi,Anil Kumar
Ekta Singh
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy affecting millions of individuals worldwide. It is believed that the prevalence of G6PD deficiency in different ethnic populat...
Higher TP53 somatic mutation prevalence from liquid biopsy analysis in ever smoker non-small-cell lung cancer patients [0.03%]
基于液体活检分析的吸烟肺癌患者中较高的TP53体细胞突变发生率
Haktan Bağış Erdem,Mustafa Tarık Alay,Zeynep Özdemir et al.
Haktan Bağış Erdem et al.
Objective: Cigarette smoking is a primary risk factor, linked to 80% of LC deaths. TP53, a key gene, is implicated in various cancers, with TP53 alterations in 36.7% of cancers. This research aims to investigate TP53 muta...
Variants in exon 2 of MED12 gene causes uterine leiomyoma's through over-expression of MMP-9 of ECM pathway [0.03%]
MED12基因外显子2的变异通过ECM途径中基质金属蛋白酶9表达过多导致子宫肌瘤生成
Vivek Pandey,Priyanka Jain,Souradip Chatterjee et al.
Vivek Pandey et al.
Aims: To study the impact of Mediator complex subunit 12 (MED12) gene variants on the encoded protein's function and pathogenic relevance for genesis of uterine leiomyoma's (ULs). ...
The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis [0.03%]
DNA聚合酶eta精确绕过嘧啶二聚体对紫外线诱导突变的贡献
C F M Menck,R S Galhardo,A Quinet
C F M Menck
Human xeroderma pigmentosum variant (XP-V) patients are mutated in the POLH gene, responsible for encoding the translesion synthesis (TLS) DNA polymerase eta (Pol eta). These patients suffer from a high frequency of skin tumors. Despite sev...