MicroRNA-532 as a probable diagnostic and therapeutic marker in cancer patients [0.03%]
microRNA-532可能作为癌症患者的诊断和治疗标志物
Malihe Lotfi,Amirhosein Maharati,Amir Abbas Hamidi et al.
Malihe Lotfi et al.
The high mortality rate in cancer patients is always one of the main challenges of the health systems globally. Several factors are involved in the high rate of cancer related mortality, including late diagnosis and drug resistance. Cancer ...
MicroRNA-138 promotes the progression of multiple myeloma through targeting paired PAX5 [0.03%]
微小核糖核酸-138通过靶向paired PAX5促进多发性骨髓瘤进展
Xiao Yan,Keting Wang,Cong Shi et al.
Xiao Yan et al.
Background: Multiple myeloma cancer stem cells (MMSC) have been considered as the leading cause of multiple myeloma (MM) drug resistance and eventual relapse, microRNAs (miRNAs) collectively participate in the progression...
AQP5 promotes epithelial-mesenchymal transition and tumor growth through activating the Wnt/β-catenin pathway in triple-negative breast cancer [0.03%]
AQP5通过激活Wnt/β-连环蛋白信号通路促进三阴性乳腺癌的上皮间质转化及肿瘤生长
Zhengcai Zhu,Tao Li,Honggang Wang et al.
Zhengcai Zhu et al.
Background: Emerging data identifies aquaporin 5 (AQP5) as a vital player in many kinds of cancers. Over expression of AQP5 was associated with increased metastasis and poor prognosis, suggesting that AQP5 may facilitate ...
ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes [0.03%]
乙醛脱氢酶2基因变异及在癌症和遗传性骨髓衰竭综合征中的保护作用
Anthony Yiu-Ho Woo,Lina Jia
Anthony Yiu-Ho Woo
Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion called interstrand crosslink (ICL). Aldehyde-metabolizing enzymes such ...
Wesley Bush,Korey Bosart,Renee A Bouley et al.
Wesley Bush et al.
Homologous recombination (HR) is essential for repair of DNA double-strand breaks (DSBs) and restart of stalled or collapsed replication forks. Most cancers are characterized by mutations in components of the DSB repair pathways. Redundant ...
HSPE1 enhances aerobic glycolysis to promote progression of lung adenocarcinoma [0.03%]
HSPE1通过增强肺腺癌细胞的糖酵解促进肿瘤进展
Tao Xie,Manxiang Li
Tao Xie
Objective: This study aimed to explore the role of heat shock protein family E member 1 (HSPE1) in the metabolism of lung adenocarcinoma (LUAD) cells. Met...
PAX8-AS1/microRNA-25-3p/LATS2 regulates malignant progression of ovarian cancer via Hippo signaling [0.03%]
PAX8-AS1/miR-25-3p/LATS2通过Hippo信号通路调节卵巢癌恶性进展
Gang Liu,Jing Tian
Gang Liu
Background: Ovarian cancer (OC) is a frequent malignancy of the female reproductive system. Recently, the aberrant expression of numerous lncRNAs has been confirmed as a key factor for cancer development. The regulatory r...
Low-molecular-weight fucoidan increases telomere length and immunostimulatory effects on NK-92 cells following inhaled anesthetic injury [0.03%]
低分子褐藻糖胶通过吸入麻醉损伤后增加端粒长度和NK-92细胞免疫刺激作用
Cheng-Hsi Chang,Pai-An Hwang
Cheng-Hsi Chang
Inhaled anesthetics, such as isoflurane, may cause side effects, including short-term immunosuppression and DNA damage. In contrast, low molecular weight fucoidan (LMF), derived from brown seaweed, exhibits promising immunomodulatory effect...
A pilot study exploring time- and dose-dependent DNA damage and chromosomal instability caused by benzo[a]pyrene in two urothelial cell types [0.03%]
一项关于苯并[a]芘在两种尿路上皮细胞类型中引起的时间和剂量依赖性DNA损伤和染色体不稳定性的试点研究
Jonas Wohlfahrt,Nisha Verma,Rasha Alsaleh et al.
Jonas Wohlfahrt et al.
Environmental and occupational exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse health effects in humans. Uncertainty exists regarding the causation of urinary bladder cancer by benzo[a]pyrene (B[a]P) due to a ...
Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC) [0.03%]
基于铂的肺癌靶向化学疗法及顺铂耐药逆转
Hassaan Umar,Habibah A Wahab,Ali Attiq et al.
Hassaan Umar et al.
Lung cancer is the one of the most prevalent cancer in the world. It kills more people from cancer than any other cause and is especially common in underdeveloped nations. With 1.2 million instances, it is also the most prevalent cancer in ...