Sherry G Dodds,Gene Hubbard,Yong Jun Choi et al.
Sherry G Dodds et al.
RAD51 is critical to the homologous recombination (HR) pathway that repairs DNA double strand breaks (DSBs) and protects replication forks (RFs). Previously, we showed that the S181P (SP) mutation in RAD51 causes defective RF maintenance bu...
Saikosaponin-d mediates FOXG1 to reverse docetaxel resistance in prostate cancer through oxidative phosphorylation [0.03%]
补骨脂苦素通过氧化磷酸化介导FOXG1逆转多西他赛耐药性在前列腺癌中的作用
Jun Meng,Bo Yang,Chang Shu et al.
Jun Meng et al.
Background: Prostate cancer (PCa), a prevalent malignancy worldwide, is frequently identified in advanced stages due to the absence of distinctive early symptoms, thereby culminating in the development of chemotherapy-ind...
ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells [0.03%]
利用CRISPR/Cas9在CHO细胞中进行ATM和ATR基因的编辑
Junko Maeda,Piyawan Chailapakul,Takamitsu A Kato
Junko Maeda
Chinese hamster-derived cell lines including Chinese hamster lung fibroblasts (V79) have been used as model somatic cell lines in radiation biology and toxicology research for decades and have been instrumental in advancing our understandin...
miR-129-2-3p binds SEMA4C to regulate HCC development and inhibit the EMT [0.03%]
miR-129-2-3p通过结合SEMA4C调控肝癌的发生发展并抑制EMT现象
Siyuan Ma,Chun Pu
Siyuan Ma
Background: Among primary liver cancers, HCC is the most prevalent. Small noncoding RNAs called miRNAs control the expression of downstream target genes to take part in a variety of physiological and pathological processe...
Transcription factor NFYA inhibits ferroptosis in lung adenocarcinoma cells by regulating PEBP1 [0.03%]
转录因子NFYA通过调节PEBP1抑制肺腺癌细胞铁死亡
Feng Chen,Tingting Xu,Ni Jin et al.
Feng Chen et al.
Background: Ferroptosis is an iron-dependent programmed cell death mediated by lipid peroxidation. The purpose was to explore the molecular mechanism by which phosphatidylethanolamine-binding protein 1 (PEBP1) regulates f...
MicroRNA-532 as a probable diagnostic and therapeutic marker in cancer patients [0.03%]
microRNA-532可能作为癌症患者的诊断和治疗标志物
Malihe Lotfi,Amirhosein Maharati,Amir Abbas Hamidi et al.
Malihe Lotfi et al.
The high mortality rate in cancer patients is always one of the main challenges of the health systems globally. Several factors are involved in the high rate of cancer related mortality, including late diagnosis and drug resistance. Cancer ...
MicroRNA-138 promotes the progression of multiple myeloma through targeting paired PAX5 [0.03%]
微小核糖核酸-138通过靶向paired PAX5促进多发性骨髓瘤进展
Xiao Yan,Keting Wang,Cong Shi et al.
Xiao Yan et al.
Background: Multiple myeloma cancer stem cells (MMSC) have been considered as the leading cause of multiple myeloma (MM) drug resistance and eventual relapse, microRNAs (miRNAs) collectively participate in the progression...
AQP5 promotes epithelial-mesenchymal transition and tumor growth through activating the Wnt/β-catenin pathway in triple-negative breast cancer [0.03%]
AQP5通过激活Wnt/β-连环蛋白信号通路促进三阴性乳腺癌的上皮间质转化及肿瘤生长
Zhengcai Zhu,Tao Li,Honggang Wang et al.
Zhengcai Zhu et al.
Background: Emerging data identifies aquaporin 5 (AQP5) as a vital player in many kinds of cancers. Over expression of AQP5 was associated with increased metastasis and poor prognosis, suggesting that AQP5 may facilitate ...
ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes [0.03%]
乙醛脱氢酶2基因变异及在癌症和遗传性骨髓衰竭综合征中的保护作用
Anthony Yiu-Ho Woo,Lina Jia
Anthony Yiu-Ho Woo
Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion called interstrand crosslink (ICL). Aldehyde-metabolizing enzymes such ...
Wesley Bush,Korey Bosart,Renee A Bouley et al.
Wesley Bush et al.
Homologous recombination (HR) is essential for repair of DNA double-strand breaks (DSBs) and restart of stalled or collapsed replication forks. Most cancers are characterized by mutations in components of the DSB repair pathways. Redundant ...