Understanding the nucleotide composition and patterns of codon usage in the expression of human oral cancer genes [0.03%]
人类口腔癌基因表达中的核苷酸组成及密码子使用模式的理解
Tarikul Huda Mazumder,Arif Uddin
Tarikul Huda Mazumder
Oral squamous cell carcinoma (OSCC) is primarily known as oral cancer (OC) that mostly occurs in mouth, lips and tongue. Mutations in some of the genes cause OC and some genes are risk factors for progression of OC. In this study, we analyz...
Apiole, an important constituent of parsley, is a mixed-type inhibitor of the CYP1A subfamily [0.03%]
芹菜子醇是一种重要的伞形科植物茋类成分，是CYP1A亚家族的混合型抑制剂
J J Espinosa-Aguirre,R Camacho-Carranza,S L Hernández-Ojeda et al.
J J Espinosa-Aguirre et al.
Apiole (1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene) and parsley leaves ethanolic extract containing it inhibit the rat liver microsomal ethoxy- and methoxyresorufin-O-deacetylase activities associated with cytochrome P450 (CYP) 1A1 and...
CircRNA ATF6 suppresses bladder cancer cell proliferation and migration via miR-146a-5p/FLNA axis [0.03%]
环状RNA ATF6通过miR-146a-5p/FLNA轴抑制膀胱癌细胞增殖和迁移
Bing Lu,Yongqiang Zhou,Zheng Ma et al.
Bing Lu et al.
Background: Bladder cancer (BCa) is the most common malignancy with increasing morbidity and mortality. Circular RNA (circRNA) ATF6 level was downregulated in BCa after GSE92675 CircRNA microarray dataset was analyzed usi...
NTSR1 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma through the Wnt/β-catenin pathway [0.03%]
NTSR1通过Wnt/β-catenin信号通路促进肺腺癌的上皮间质转化和转移
Zhihao Zhang,Dongliang Zhang,Kai Su et al.
Zhihao Zhang et al.
Background: Lung adenocarcinoma (LUAD) patients are implicated in poor prognoses and increased mortality rates. Metastasis, as a leading cause of LUAD-related deaths, requires further investigation. Highly metastatic canc...
Therapeutic potential of curcumin in autophagy modulation: Insights into the role of transcription factor EB [0.03%]
姜黄素在自噬调节中的治疗潜力：转录因子EB的作用机制初探
Shabnam Radbakhsh,Prashant Kesharwani,Amirhossein Sahebkar
Shabnam Radbakhsh
Transcription factor EB (TFEB) is a basic Helix-Loop-Helix/Leucine Zipper (bHLHZip) class of DNA-binding proteins, which can control the expression of genes included in the autophagy-lysosomal pathway. TFEB regulates the autophagic flux by ...
Sherry G Dodds,Gene Hubbard,Yong Jun Choi et al.
Sherry G Dodds et al.
RAD51 is critical to the homologous recombination (HR) pathway that repairs DNA double strand breaks (DSBs) and protects replication forks (RFs). Previously, we showed that the S181P (SP) mutation in RAD51 causes defective RF maintenance bu...
Saikosaponin-d mediates FOXG1 to reverse docetaxel resistance in prostate cancer through oxidative phosphorylation [0.03%]
补骨脂苦素通过氧化磷酸化介导FOXG1逆转多西他赛耐药性在前列腺癌中的作用
Jun Meng,Bo Yang,Chang Shu et al.
Jun Meng et al.
Background: Prostate cancer (PCa), a prevalent malignancy worldwide, is frequently identified in advanced stages due to the absence of distinctive early symptoms, thereby culminating in the development of chemotherapy-ind...
ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells [0.03%]
利用CRISPR/Cas9在CHO细胞中进行ATM和ATR基因的编辑
Junko Maeda,Piyawan Chailapakul,Takamitsu A Kato
Junko Maeda
Chinese hamster-derived cell lines including Chinese hamster lung fibroblasts (V79) have been used as model somatic cell lines in radiation biology and toxicology research for decades and have been instrumental in advancing our understandin...
miR-129-2-3p binds SEMA4C to regulate HCC development and inhibit the EMT [0.03%]
miR-129-2-3p通过结合SEMA4C调控肝癌的发生发展并抑制EMT现象
Siyuan Ma,Chun Pu
Siyuan Ma
Background: Among primary liver cancers, HCC is the most prevalent. Small noncoding RNAs called miRNAs control the expression of downstream target genes to take part in a variety of physiological and pathological processe...
Transcription factor NFYA inhibits ferroptosis in lung adenocarcinoma cells by regulating PEBP1 [0.03%]
转录因子NFYA通过调节PEBP1抑制肺腺癌细胞铁死亡
Feng Chen,Tingting Xu,Ni Jin et al.
Feng Chen et al.
Background: Ferroptosis is an iron-dependent programmed cell death mediated by lipid peroxidation. The purpose was to explore the molecular mechanism by which phosphatidylethanolamine-binding protein 1 (PEBP1) regulates f...