SIRT6 regulates the HIPK2/P53 pathway to reduce oxidative stress and apoptosis to attenuate vancomycin-induced nephrotoxicity [0.03%]
SIRT6通过调控HIPK2/P53途径减轻氧化应激和细胞凋亡来缓解万古霉素肾毒性
Xiuying Feng,Yunhui Liu,Lei Su et al.
Xiuying Feng et al.
SIRT6 is known to play a protective role in several kidney diseases; however, its role in vancomycin-induced renal injury remains unclear. This study aims to confirm the role and related mechanisms of SIRT6 in vancomycin-induced renal injur...
Genomic and molecular landscape of gallbladder cancer elucidating pathogenic mechanisms novel therapeutic targets and clinical implications [0.03%]
胆囊癌的基因组和分子谱揭示了致病机制、新的治疗目标及临床意义
Manishankar Kumar,Arun Kumar,Abhinav Srivastav et al.
Manishankar Kumar et al.
Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis, often diagnosed at advanced stages due to subtle early symptoms. Recent studies have provided a comprehensive view of GBC's genetic and mutational landscape, uncove...
Evaluation of the simultaneous effects of KRAS G12V and LCS6 alterations on the behavior of head and neck squamous cell carcinoma [0.03%]
KRAS G12V和LCS6改变对头颈鳞状细胞癌行为的协同作用评估
Vildan Betul Yenigun,Vasfiye Betul Ucar,Zeynep Betul Sari et al.
Vildan Betul Yenigun et al.
Background: Head and neck squamous cell carcinomas are the seventh most common cancer accounting for 90 % of malignant neoplasia of the upper respiratory system. KRAS is a very important oncogene, leading to the suppressi...
High expression of SLC34A2 contributes to chemoresistance of non-small cell lung cancer against gefitinib: The critical role of miR-124-3p [0.03%]
SLC34A2高表达通过介导 gefitinib 耐药促进非小细胞肺癌发展的分子机制研究：miR-124-3p 的关键作用
Chao Tan,Li Zhang,Sai Chen et al.
Chao Tan et al.
Gefitinib is a therapeutic agent used to treat lung carcinoma, including non-small cell lung cancer (NSCLC). However, mechanisms underlying NSCLC cell resistance to gefitinib remain largely uncharacterized. In this study, we explored the as...
The mutagenic properties of formaldehyde and acetaldehyde: Reflections on half a century of progress [0.03%]
甲醛和乙醛的致突变性：半个世纪的进步反思
Mahanish Jung Thapa,Kin Chan
Mahanish Jung Thapa
Formaldehyde and acetaldehyde are reactive, small compounds that humans are exposed to routinely, variously from endogenous and exogenous sources. Both small aldehydes are classified as human carcinogens. Investigation of the DNA damaging p...
Yeak-Wun Quek,Yu-Ting Kang,Hsu Chih Huang et al.
Yeak-Wun Quek et al.
Fine particulate matter (PM2.5) is a common major air pollutant associated with decreased lung function, induced allergic airway inflammation closely correlated with chronic lung diseases. Angiopoietin-like protein 4 (ANGPTL4) is a cytokine...
Knockdown of SDCBP induces autophagy to promote cardiomyocyte growth and angiogenesis in hypoxia/reoxygenation model [0.03%]
SDCBP基因敲低通过诱导自噬促进缺氧/复氧模型中心肌细胞增殖及新生血管形成
Ling Gao,Wanqian Liu
Ling Gao
Objective: Angina, myocardial infarction, and even mortality can result from myocardial ischemia (MI). Angiogenesis facilitates tissue repair, lessens cell damage, and ensures that ischemic tissues receive blood and oxyge...
Agrimonolide inhibits glycolysis in ovarian cancer cells by regulating HIF1A [0.03%]
Agrimonolide通过调节HIF1A抑制卵巢癌细胞的糖酵解作用
Yi Yang,Huimin Wang,Qiong Wei et al.
Yi Yang et al.
Background: Ovarian cancer is one of the most common tumors affecting females, significantly disrupting their quality of life. Agrimonolide, an extract derived from Agrimony (Agrimonia pilosa Ledeb.), has been shown to ex...
Molecular dynamics of DNA repair and carcinogen interaction: Implications for cancer initiation, progression, and therapeutic strategies [0.03%]
DNA修复和致癌物相互作用的分子动力学：对癌症发生、发展及治疗策略的意义
Eman Alyafeai,Eskandar Qaed,Haitham Saad Al-Mashriqi et al.
Eman Alyafeai et al.
The integrity of the genetic material in human cells is continuously challenged by environmental agents and endogenous stresses. Among these, environmental carcinogens are pivotal in initiating complex DNA lesions that can lead to malignant...
HOXA1 promotes epithelial-mesenchymal transition and malignant characteristics of laryngeal squamous cell carcinoma [0.03%]
HOXA1促进喉鳞状细胞癌上皮间质转化及恶性行为
Jun Wu,Xiaofeng Gu
Jun Wu
Despite considerable advancements in the diagnosis and treatment of LSCC, there has been no significant improvement in survival rate. Consequently, identifying molecular targets for this cancer is of paramount importance. HOXA1, a constitue...