E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma [0.03%]
E2F1激活USP19以影响c-Myc的稳定性来促进肝细胞癌的发展
Di Zhang,Xinwu Zhang,Shuai Chang et al.
Di Zhang et al.
Background: Hepatocellular carcinoma (HCC) is the most common malignant tumor worldwide with a high mortality rate. Herein, this study aims to explore the molecular mechanisms of E2F transcription factor 1 (E2F1), ubiquit...
The mechanism underlying the oncogenic potential of AAA+ ATPase PSMC4 in cancer is revealed by mutations and copy number amplifications [0.03%]
AAA+ATP酶PSMC4在癌症中的致瘤潜力机制由突变和拷贝数扩增揭示
Sanjida Mallick,Qurratulain Qamar,Bibhudutta Mishra et al.
Sanjida Mallick et al.
Recent research has discovered a connection between the AAA+ ATPase PSMC4 (Proteasome 26S Subunit, ATPase 4) and several forms of cancer. However, a detailed analysis of the oncogenic potential of PSMC4 was elusive. In this study, we antici...
Cytotoxicity of allyl isothiocyanate and its metabolites in hepatocellular carcinoma HepG2 cells [0.03%]
丙烯酰异硫氰酸酯及其代谢物对肝癌HepG2细胞的细胞毒性研究
Takashi Hashimoto,Shino Nakamura,Takeshi Suzuki et al.
Takashi Hashimoto et al.
Objective: To investigate the mechanisms by which allyl isothiocyanate (AITC) exerts its anticancer effects, the present study investigated the cytotoxic effects of AITC and its metabolites on hepatocellular carcinoma Hep...
CUEDC1 promotes the growth, migration, epithelial-mesenchymal transition and inhibits apoptosis of hepatocellular carcinoma cells via the TGF-β/Smad signaling pathway [0.03%]
CUEDC1通过TGF-β/Smad信号通路促进肝癌细胞的生长，迁移，上皮间充质转化和抑制凋亡
Angjian Zhou,Fuyu Chen,Zhongchao Chen
Angjian Zhou
Purpose: To explore the precise molecular by which CUEDC1, a 42 kDa protein containing a CUE domain located on chromosome 17q22, contributes to liver cancer metastasis. ...
The complex development of psoralen-interstrand crosslink resistance in Escherichia coli requires AcrR inactivation, retention of a marbox sequence, and one of three MarA, SoxS, or Rob global regulators [0.03%]
光敏化合物补骨脂素引起的大肠杆菌细胞间交联修复的复杂性要求AcrR失活、保留一个mar盒序列，并需要三种全局调节因子之一：MarA、SoxS或Rob
Travis K Worley,Ayah H Asal,Lo Cooper et al.
Travis K Worley et al.
Crosslinking agents, such as psoralen and UVA radiation, can be effectively used as antimicrobials and for treating several dysplastic conditions in humans, including some cancers. Yet, both cancer cells and bacteria can become resistant to...
SIRT6 regulates the HIPK2/P53 pathway to reduce oxidative stress and apoptosis to attenuate vancomycin-induced nephrotoxicity [0.03%]
SIRT6通过调控HIPK2/P53途径减轻氧化应激和细胞凋亡来缓解万古霉素肾毒性
Xiuying Feng,Yunhui Liu,Lei Su et al.
Xiuying Feng et al.
SIRT6 is known to play a protective role in several kidney diseases; however, its role in vancomycin-induced renal injury remains unclear. This study aims to confirm the role and related mechanisms of SIRT6 in vancomycin-induced renal injur...
Genomic and molecular landscape of gallbladder cancer elucidating pathogenic mechanisms novel therapeutic targets and clinical implications [0.03%]
胆囊癌的基因组和分子谱揭示了致病机制、新的治疗目标及临床意义
Manishankar Kumar,Arun Kumar,Abhinav Srivastav et al.
Manishankar Kumar et al.
Gallbladder cancer (GBC) is an aggressive malignancy with a poor prognosis, often diagnosed at advanced stages due to subtle early symptoms. Recent studies have provided a comprehensive view of GBC's genetic and mutational landscape, uncove...
Evaluation of the simultaneous effects of KRAS G12V and LCS6 alterations on the behavior of head and neck squamous cell carcinoma [0.03%]
KRAS G12V和LCS6改变对头颈鳞状细胞癌行为的协同作用评估
Vildan Betul Yenigun,Vasfiye Betul Ucar,Zeynep Betul Sari et al.
Vildan Betul Yenigun et al.
Background: Head and neck squamous cell carcinomas are the seventh most common cancer accounting for 90 % of malignant neoplasia of the upper respiratory system. KRAS is a very important oncogene, leading to the suppressi...
High expression of SLC34A2 contributes to chemoresistance of non-small cell lung cancer against gefitinib: The critical role of miR-124-3p [0.03%]
SLC34A2高表达通过介导 gefitinib 耐药促进非小细胞肺癌发展的分子机制研究：miR-124-3p 的关键作用
Chao Tan,Li Zhang,Sai Chen et al.
Chao Tan et al.
Gefitinib is a therapeutic agent used to treat lung carcinoma, including non-small cell lung cancer (NSCLC). However, mechanisms underlying NSCLC cell resistance to gefitinib remain largely uncharacterized. In this study, we explored the as...
The mutagenic properties of formaldehyde and acetaldehyde: Reflections on half a century of progress [0.03%]
甲醛和乙醛的致突变性：半个世纪的进步反思
Mahanish Jung Thapa,Kin Chan
Mahanish Jung Thapa
Formaldehyde and acetaldehyde are reactive, small compounds that humans are exposed to routinely, variously from endogenous and exogenous sources. Both small aldehydes are classified as human carcinogens. Investigation of the DNA damaging p...