In silico report on five high-risk protein C pathogenic variants: G403R, P405S, S421N, C238S, and I243T [0.03%]
五种高风险蛋白C致病性变异(G403R、P405S、S421N、C238S和I243T)的模拟报告
Daniela Hristov,Done Stojanov
Daniela Hristov
In this study, we propose reclassification of 5 out of 16 PROC VUS (variants of uncertain significance): C238S, I243T, G403R, P405S, and S421N, as pathogenic variants, associated with thrombophilia due to PROC deficiency. The obtained resul...
Integrating classical genetics and whole-genome sequencing to reveal the chromosomal basis of hygromycin resistance in Escherichia coli [0.03%]
经典遗传学与全基因组测序结合揭示大肠杆菌潮霉素抗性的染色体机制
Madhumathi Irulappan,Prabhakara Sethupathy Ramkumar,Jeyaprakash Rajendhran et al.
Madhumathi Irulappan et al.
Hygromycin B (HygB), a broad-spectrum antibiotic, is widely used in molecular biology, agriculture, and veterinary medicine. It inhibits protein synthesis by binding to ribosomes, and its plasmid-borne resistance gene serves as a selectable...
Targeting cancer-cell mitochondria using Tigecycline improves radiotherapy response in colorectal cancer cell line [0.03%]
用替加环素靶向结直肠癌细胞线粒体以提高放射治疗的响应效果
Sepideh Hassanpour Khodaei,Shahnaz Sabetkam,Zeinab Mazloumi et al.
Sepideh Hassanpour Khodaei et al.
Background: Colorectal cancer (CRC) is the third most common cancer worldwide and causes more than 50,000 deaths in the United States each year. Due to the limited therapeutic options and poor prognosis in CRC, extensive ...
APOC1, transcriptionally regulated by FOXM1, promotes M2 macrophage polarization and cervical cancer progression [0.03%]
由FOXM1转录调节的APOC1促进M2巨噬极化和宫颈癌进展
Qing Chai,Yan Qi,Xiaoyan Nie et al.
Qing Chai et al.
Background: Cervical cancer (CC) is a common malignant tumor in women. M2 macrophages are associated with tumor growth, metastasis, and immunosuppression. Apolipoprotein C1 (APOC1) has been confirmed as an oncogene in CC....
In silico identification of multidrug resistance gene (MDR)-targeted transposon miRNAs in human cancer [0.03%]
基于计算机的在人类癌症中多重耐药基因(MDR)靶向转座miRNAs的识别
Seda Mesci
Seda Mesci
miRNAs are small RNA molecules that regulate gene expression and play important roles in various biological processes in cells. The discovery of miRNAs is also of great importance in cancer research. miRNAs enable the development of new app...
E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma [0.03%]
E2F1激活USP19以影响c-Myc的稳定性来促进肝细胞癌的发展
Di Zhang,Xinwu Zhang,Shuai Chang et al.
Di Zhang et al.
Background: Hepatocellular carcinoma (HCC) is the most common malignant tumor worldwide with a high mortality rate. Herein, this study aims to explore the molecular mechanisms of E2F transcription factor 1 (E2F1), ubiquit...
The mechanism underlying the oncogenic potential of AAA+ ATPase PSMC4 in cancer is revealed by mutations and copy number amplifications [0.03%]
AAA+ATP酶PSMC4在癌症中的致瘤潜力机制由突变和拷贝数扩增揭示
Sanjida Mallick,Qurratulain Qamar,Bibhudutta Mishra et al.
Sanjida Mallick et al.
Recent research has discovered a connection between the AAA+ ATPase PSMC4 (Proteasome 26S Subunit, ATPase 4) and several forms of cancer. However, a detailed analysis of the oncogenic potential of PSMC4 was elusive. In this study, we antici...
Cytotoxicity of allyl isothiocyanate and its metabolites in hepatocellular carcinoma HepG2 cells [0.03%]
丙烯酰异硫氰酸酯及其代谢物对肝癌HepG2细胞的细胞毒性研究
Takashi Hashimoto,Shino Nakamura,Takeshi Suzuki et al.
Takashi Hashimoto et al.
Objective: To investigate the mechanisms by which allyl isothiocyanate (AITC) exerts its anticancer effects, the present study investigated the cytotoxic effects of AITC and its metabolites on hepatocellular carcinoma Hep...
CUEDC1 promotes the growth, migration, epithelial-mesenchymal transition and inhibits apoptosis of hepatocellular carcinoma cells via the TGF-β/Smad signaling pathway [0.03%]
CUEDC1通过TGF-β/Smad信号通路促进肝癌细胞的生长，迁移，上皮间充质转化和抑制凋亡
Angjian Zhou,Fuyu Chen,Zhongchao Chen
Angjian Zhou
Purpose: To explore the precise molecular by which CUEDC1, a 42 kDa protein containing a CUE domain located on chromosome 17q22, contributes to liver cancer metastasis. ...
The complex development of psoralen-interstrand crosslink resistance in Escherichia coli requires AcrR inactivation, retention of a marbox sequence, and one of three MarA, SoxS, or Rob global regulators [0.03%]
光敏化合物补骨脂素引起的大肠杆菌细胞间交联修复的复杂性要求AcrR失活、保留一个mar盒序列，并需要三种全局调节因子之一：MarA、SoxS或Rob
Travis K Worley,Ayah H Asal,Lo Cooper et al.
Travis K Worley et al.
Crosslinking agents, such as psoralen and UVA radiation, can be effectively used as antimicrobials and for treating several dysplastic conditions in humans, including some cancers. Yet, both cancer cells and bacteria can become resistant to...