Computational analysis of functional, structural and pathogenic impacts of missense SNPs in the human SOCS3 gene [0.03%]
人类SOCS3基因中错义多态性的功能、结构和致病影响的计算分析
Raviteja Reddy Alipeddi,Durga Neeharika Rani,Pallavi Sampanmudumby et al.
Raviteja Reddy Alipeddi et al.
The Suppressor of Cytokine Signaling 3 (SOCS3) protein is a crucial negative regulator of cytokine-mediated signaling pathways, and genetic variations in SOCS3 have been implicated in the development of multiple multi-factorial diseases (MF...
Role of c-Myc-regulated miR-196a-5p in the progression of triple-negative breast cancer: Potential involvement of HOXA7 and HOXB7 [0.03%]
c-Myc调节的miR-196a-5p在三阴性乳腺癌进展中的作用：HOXA7和HOXB7的潜在参与作用
Xin-Yu Song,Le Yang,Hui-Ling Li et al.
Xin-Yu Song et al.
Objective: This study aimed to elucidate the regulatory role of c-Myc-associated miR-196a-5p in the progression of triple-negative breast cancer (TNBC). We further explored its target genes to investigate possible mechani...
DNA double-strand breaks induced by DNA topoisomerase IIα and reactive oxygen species lead to the integration of foreign DNA into the host genome [0.03%]
由DNA拓扑异构酶IIα和活性氧引起的DNA双链断裂导致外源DNA整合到宿主基因组中
Aya Kurosawa,Masumi Umehara,Noritaka Adachi
Aya Kurosawa
Foreign DNA integrates into the genome at low frequencies and random positions upon introduction into cells. This phenomenon, known as random integration, occurs when DNA double-strand breaks (DSBs) are repaired by non-homologous end-joinin...
FOXA2 promotes glutamine metabolism to facilitate the malignant development of bladder cancer by transcriptionally increasing GLS1 expression [0.03%]
FOXA2通过转录增强GLS1表达促进谷氨酰胺代谢以促进膀胱癌恶性发展
Quan Yuan,Bowen Liu,Wei Yan et al.
Quan Yuan et al.
Background: Forkhead box A2 (FOXA2) is found to be abnormally overexpressed in bladder cancer (BCa), but its role and underlying molecular mechanisms in BCa progression remain revealed. ...
Implications of seven NTCP mutations for receptor stability and Hepatitis B Virus infectivity: A computational analysis [0.03%]
七个NTCP突变对受体稳定性和乙型肝炎病毒感染性的影响的计算分析
Amina Kardoudi,Salaheddine Redouane,Salma Madihi et al.
Amina Kardoudi et al.
Hepatitis B is a widespread viral infection and a major global public health concern. The human sodium taurocholate co-transporter polypeptide (NTCP) serves as a key receptor for the hepatitis B virus (HBV), enabling its entry into hepatocy...
Repeated artificial mutagenesis of Bradyrhizobium diazoefficiens by gamma irradiation accelerates the acquisition of high-temperature tolerance [0.03%]
伽玛射线照射土著根瘤菌Burkholderia dewingsii进行重复人工诱变可加速其高温耐受性的获得
Yoshihiro Hase,Ikuko Nagafune,Katsuya Satoh
Yoshihiro Hase
Effective mutant screening is critical for improving industrial microorganisms. This study was conducted to evaluate the effect of repeated mutagenesis with gamma rays on the experimental evolution of rhizobial high-temperature tolerance. W...
CPMFD: An algorithm for Classification of Point Mutations together with Frameshift Determination in related mRNA sequences [0.03%]
基于与mRNA相关序列的分类算法CPMFD及其帧移判定功能
Probir Mondal,Pratyay Banerjee,Krishnendu Basuli
Probir Mondal
Mutations are responsible for the genetic origin of various diseases. Existing techniques for mutation identification often fails to detect the full spectrum of mutations in complex genomes hindering progress in diagnosis, treatment and pre...
Hypoxia-induced HIF-1α enhanced the tumorigenesis in non-small cell lung cancer by targeting GAB2 [0.03%]
缺氧诱导的HIF-1α通过靶向GAB2增强非小细胞肺癌的肿瘤发生能力
Xunxia Zhu,Xiaoyong Shen,Xiaoyu Chen et al.
Xunxia Zhu et al.
Non-small cell lung cancer (NSCLC) is a lethal disease with high morbidity and mortality rates. HIF-1α is confirmed to be involved in NSCLC. However, the detailed mechanism of its role remains unclear. NCI-H226 and SK-MES-1 cell lines were...
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology [0.03%]
基于单细胞转录组学技术解码YY1/HIF1A调控卵巢癌血管生成的分子机制
Xiyun Quan,Huimei Yi,Meiyuan Huang et al.
Xiyun Quan et al.
Background: Angiogenesis assumes an essential role in tumor development and is a fundamental condition for tumor growth. Yin Yang 1 (YY1) is highly expressed in various types of cancers and is a key player in tumor angiog...
Analysis of TERT promoter hotspot mutations using droplet digital PCR in hepatoblastoma and hepatocellular carcinoma [0.03%]
采用数字droplet PCR分析肝母细胞瘤和肝细胞癌中TERT启动子热点突变
Yoko Hiyama,Masato Kojima,Sho Kurihara et al.
Yoko Hiyama et al.
Somatic mutations in the telomerase reverse transcriptase promoter (TERTp) region are common in many cancers, including in liver cancers. Detection of TERTp mutations in tumor tissue DNAs and cell-free tumor DNAs is useful for diagnosing an...