Repeated artificial mutagenesis of Bradyrhizobium diazoefficiens by gamma irradiation accelerates the acquisition of high-temperature tolerance [0.03%]
伽玛射线照射土著根瘤菌Burkholderia dewingsii进行重复人工诱变可加速其高温耐受性的获得
Yoshihiro Hase,Ikuko Nagafune,Katsuya Satoh
Yoshihiro Hase
Effective mutant screening is critical for improving industrial microorganisms. This study was conducted to evaluate the effect of repeated mutagenesis with gamma rays on the experimental evolution of rhizobial high-temperature tolerance. W...
CPMFD: An algorithm for Classification of Point Mutations together with Frameshift Determination in related mRNA sequences [0.03%]
基于与mRNA相关序列的分类算法CPMFD及其帧移判定功能
Probir Mondal,Pratyay Banerjee,Krishnendu Basuli
Probir Mondal
Mutations are responsible for the genetic origin of various diseases. Existing techniques for mutation identification often fails to detect the full spectrum of mutations in complex genomes hindering progress in diagnosis, treatment and pre...
Hypoxia-induced HIF-1α enhanced the tumorigenesis in non-small cell lung cancer by targeting GAB2 [0.03%]
缺氧诱导的HIF-1α通过靶向GAB2增强非小细胞肺癌的肿瘤发生能力
Xunxia Zhu,Xiaoyong Shen,Xiaoyu Chen et al.
Xunxia Zhu et al.
Non-small cell lung cancer (NSCLC) is a lethal disease with high morbidity and mortality rates. HIF-1α is confirmed to be involved in NSCLC. However, the detailed mechanism of its role remains unclear. NCI-H226 and SK-MES-1 cell lines were...
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology [0.03%]
基于单细胞转录组学技术解码YY1/HIF1A调控卵巢癌血管生成的分子机制
Xiyun Quan,Huimei Yi,Meiyuan Huang et al.
Xiyun Quan et al.
Background: Angiogenesis assumes an essential role in tumor development and is a fundamental condition for tumor growth. Yin Yang 1 (YY1) is highly expressed in various types of cancers and is a key player in tumor angiog...
Analysis of TERT promoter hotspot mutations using droplet digital PCR in hepatoblastoma and hepatocellular carcinoma [0.03%]
采用数字droplet PCR分析肝母细胞瘤和肝细胞癌中TERT启动子热点突变
Yoko Hiyama,Masato Kojima,Sho Kurihara et al.
Yoko Hiyama et al.
Somatic mutations in the telomerase reverse transcriptase promoter (TERTp) region are common in many cancers, including in liver cancers. Detection of TERTp mutations in tumor tissue DNAs and cell-free tumor DNAs is useful for diagnosing an...
Corrigendum to "Saikosaponin-d Mediates FOXG1 to Reverse Docetaxel Resistance in Prostate Cancer through Oxidative Phosphorylation" [Mut. Res. - Fundam. Mol. Mech. Mutagenesis 829 (2024) 111875] [0.03%]
关于“Saikosaponin-d通过氧化磷酸化介导FOXG1逆转多西他赛耐药性前列腺癌”的勘误 [Mut. Res. - Fundam. Mol. Mech. Mutagenesis 829 (2024) 111875]
Jun Meng,Bo Yang,Chang Shu et al.
Jun Meng et al.
Published Erratum
Mutation research. 2025 Sep 11:111914. DOI:10.1016/j.mrfmmm.2025.111914 2025
DGKβ accelerates the progression of cervical cancer through ANGPT4-mediated tumor angiogenesis [0.03%]
DGKβ通过ANGPT4介导的肿瘤血管生成促进宫颈癌进展
Qing Li,Zhenyu Zhou,Xiaoying Li et al.
Qing Li et al.
Background: Cervical cancer (CC) is a major cause of morbidity and mortality in women, with complex etiology and progression. Diacylglycerol kinases (DGKs) are pivotal in lipid metabolism. Although diacylglycerol kinase b...
WTAP-mediated m6A modification of ARG2 mRNA Inhibits Its expression and drives prostate cancer malignant progression [0.03%]
WTAP介导的ARG2 mRNA去甲基化修饰抑制其表达并促进前列腺癌恶性进展
Jianxin Li,Yu Zheng,Chaojiang Chen et al.
Jianxin Li et al.
Background: Prostate cancer (PCa) incidence increases as age advances and seriously endangers men's health worldwide. Arginase 2 (ARG2) has been identified as a potential diagnostic and prognostic marker for PCa. However,...
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer [0.03%]
METTL14介导的ETV4m6A修饰抑制结直肠癌肿瘤发生发展
Xiaofeng Liao,Tao Hu
Xiaofeng Liao
Background: Many m6A methyltransferases have been identified to regulate colorectal cancer (CRC) progression. METTL14 has been confirmed to play a negative role in CRC process, but the molecular mechanism of METTL14 in re...
A novel mechanism in driving non-small cell lung cancer progression: The METTL3/FOXA1/PTK2 cascade [0.03%]
驱动非小细胞肺癌进展的新型机制：METTL3/FOXA1/PTK2信号通路
Xuelin Zhang,Yizhao Chen,Lingjie Wang et al.
Xuelin Zhang et al.
Background: Dysregulation of m6A modification has significant implications in human carcinogenesis. METTL3, a crucial m6A writer, acts as an oncogenic driver in non-small cell lung cancer (NSCLC). Here, we explored its me...