METTL3 promotes prostate cancer cell metastasis and EMT by mediating NUP210 m6A modification [0.03%]
METTL3通过介导NUP210m6A修饰促进前列腺癌细胞转移和EMT
Shaoxing Wang,Jinming Li,Jun Jiang et al.
Shaoxing Wang et al.
Background: Prostate cancer (PCa) is an age-related epithelial malignancy with high metastatic potential. Although nucleoporin 210 (NUP210) is implicated in tumor progression, its role and mechanism in PCa metastasis rema...
Effect of p53 gene mutation with loss of function on the expression of genes and proteins involved in cell proliferation [0.03%]
p53基因失活突变对增殖相关基因和蛋白质表达的影响研究
Gyeong Hee Kim,Moon-Moo Kim
Gyeong Hee Kim
The tumor suppressor gene TP53 plays a vital role in preserving genomic integrity by regulating cell cycle progression, DNA repair mechanisms, and apoptosis. This study aims to examine how CRISPR/Cas9-induced loss-of-function mutations in t...
The oncogenic role of U2AF2/HKDC1 cascade in colorectal cancer by promoting cancer cell glycolysis and malignant phenotypes [0.03%]
U2AF2/HKDC1串珠体在结直肠癌中的致癌作用：通过促进癌细胞糖酵解和恶性表型所致
Wenjuan Feng,Mingfeng Wu,Hanyang Zou et al.
Wenjuan Feng et al.
Background: Dysregulation of hexokinase domain component 1 (HKDC1), a central regulator of glucose metabolism, plays a pathogenic role in colorectal cancer (CRC). The current research investigated the RNA-binding protein ...
SPDEF-mediated BIRC5 transcriptional activation enhances non-small cell lung cancer progression [0.03%]
SPDEF介导的BIRC5转录激活促进非小细胞肺癌进展
Zhixiong Qiao,Zhiping Lv,Xuyang Song et al.
Zhixiong Qiao et al.
Background: SAM-pointed domain-containing ETS transcription factor (SPDEF), an ETS family transcription factor (TF), functions as a tumor-promoting factor in non-small cell lung cancer (NSCLC). However, the precise mechan...
Deciphering the structural and functional impact of interleukin-3 (IL-3) variants: Insights from site-directed mutagenesis, computational modeling, molecular dynamics simulations, and implications for anticancer therapies and immune regulation [0.03%]
解读白细胞介素-3（IL-3）变异体的结构和功能影响：定点突变、计算建模、分子动力学模拟及其在抗癌治疗和免疫调节中的启示
Allah Rakha Yaseen,Uzma Nisar,Munir Ahmad et al.
Allah Rakha Yaseen et al.
Interleukin-3 (IL-3) is a pivotal cytokine in immune regulation, making it a compelling target for therapeutic intervention in immune-related disorders. This study employs an integrative computational approach, combining site-directed mutag...
Computational analysis of functional, structural and pathogenic impacts of missense SNPs in the human SOCS3 gene [0.03%]
人类SOCS3基因中错义多态性的功能、结构和致病影响的计算分析
Raviteja Reddy Alipeddi,Durga Neeharika Rani,Pallavi Sampanmudumby et al.
Raviteja Reddy Alipeddi et al.
The Suppressor of Cytokine Signaling 3 (SOCS3) protein is a crucial negative regulator of cytokine-mediated signaling pathways, and genetic variations in SOCS3 have been implicated in the development of multiple multi-factorial diseases (MF...
Role of c-Myc-regulated miR-196a-5p in the progression of triple-negative breast cancer: Potential involvement of HOXA7 and HOXB7 [0.03%]
c-Myc调节的miR-196a-5p在三阴性乳腺癌进展中的作用：HOXA7和HOXB7的潜在参与作用
Xin-Yu Song,Le Yang,Hui-Ling Li et al.
Xin-Yu Song et al.
Objective: This study aimed to elucidate the regulatory role of c-Myc-associated miR-196a-5p in the progression of triple-negative breast cancer (TNBC). We further explored its target genes to investigate possible mechani...
DNA double-strand breaks induced by DNA topoisomerase IIα and reactive oxygen species lead to the integration of foreign DNA into the host genome [0.03%]
由DNA拓扑异构酶IIα和活性氧引起的DNA双链断裂导致外源DNA整合到宿主基因组中
Aya Kurosawa,Masumi Umehara,Noritaka Adachi
Aya Kurosawa
Foreign DNA integrates into the genome at low frequencies and random positions upon introduction into cells. This phenomenon, known as random integration, occurs when DNA double-strand breaks (DSBs) are repaired by non-homologous end-joinin...
FOXA2 promotes glutamine metabolism to facilitate the malignant development of bladder cancer by transcriptionally increasing GLS1 expression [0.03%]
FOXA2通过转录增强GLS1表达促进谷氨酰胺代谢以促进膀胱癌恶性发展
Quan Yuan,Bowen Liu,Wei Yan et al.
Quan Yuan et al.
Background: Forkhead box A2 (FOXA2) is found to be abnormally overexpressed in bladder cancer (BCa), but its role and underlying molecular mechanisms in BCa progression remain revealed. ...
Implications of seven NTCP mutations for receptor stability and Hepatitis B Virus infectivity: A computational analysis [0.03%]
七个NTCP突变对受体稳定性和乙型肝炎病毒感染性的影响的计算分析
Amina Kardoudi,Salaheddine Redouane,Salma Madihi et al.
Amina Kardoudi et al.
Hepatitis B is a widespread viral infection and a major global public health concern. The human sodium taurocholate co-transporter polypeptide (NTCP) serves as a key receptor for the hepatitis B virus (HBV), enabling its entry into hepatocy...