E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT [0.03%]
E2F1通过NEK2介导的Wnt/β-catenin和Notch激活及上皮间质转化促进肝癌恶性表型
Lingju Hong,Shaoying Ke,Shaoze Lin et al.
Lingju Hong et al.
Background: Hepatocellular carcinoma (LIHC) is the most common primary liver cancer, with high recurrence and metastasis rates, and its molecular mechanisms remain incompletely understood. ...
Exploring Taq polymerase induced mutations in part of BRAF exon 15 by sequencing and mutation enrichment [0.03%]
测序及变异增强法探讨Taq聚合酶诱导的BRAF外显子15部分序列突变
Per O Ekstrøm,Sigve Nakken,Eivind Hovig
Per O Ekstrøm
The polymerase chain reaction (PCR) is a fundamental technique in molecular biology, enabling the amplification of specific DNA sequences for various applications. Despite its utility, the fidelity of DNA polymerases used during amplificati...
Deubiquitinase USP10 regulates angiotensin II-induced renal fibrosis by modulating the expression of TLR4 [0.03%]
去泛素化酶USP10通过调节TLR4的表达调控血管紧张素II诱导的肾纤维化
Rong Wang,Yanjun Shen,Jiaqi Shi et al.
Rong Wang et al.
Background: Diabetic kidney disease (DKD) is one of the main causes of chronic kidney disease (CKD). There is evidence suggesting that the upregulation of Toll-like receptor 4 (TLR4) can exacerbate the progression of diab...
Maternal exposure to sucrose and maltodextrin alters metabolism and genotoxicity in mice offspring [0.03%]
母体接触蔗糖和麦芽糊精可改变后代小鼠的代谢及致突变性
Marina Lummertz Magenis,Whayne Alves Alecrim,Otávio Lúcio Possamai et al.
Marina Lummertz Magenis et al.
Early metabolic events during the intrauterine period can increase susceptibility to chronic diseases in adulthood. Fetal and neonatal nutrition rich in sugars may lead to disorders such as obesity, insulin resistance, and diabetes. This st...
Characterization of pathogenic missense mutations in nuclear encoded mitochondrial dynamin -1 like protein [0.03%]
核编码线粒体动力蛋白-1样蛋白质致病性错义突变的特征分析
Kaniha Sivakumar,Nihala Sidhic,Usha Subbiah et al.
Kaniha Sivakumar et al.
Background: The DNM1L gene encodes the dynamin-related protein, Drp1, essential for mitochondrial fission. Impaired mitochondrial division contributes to cardiovascular, neurodegenerative, and metabolic disorders. This st...
METTL3 promotes prostate cancer cell metastasis and EMT by mediating NUP210 m6A modification [0.03%]
METTL3通过介导NUP210m6A修饰促进前列腺癌细胞转移和EMT
Shaoxing Wang,Jinming Li,Jun Jiang et al.
Shaoxing Wang et al.
Background: Prostate cancer (PCa) is an age-related epithelial malignancy with high metastatic potential. Although nucleoporin 210 (NUP210) is implicated in tumor progression, its role and mechanism in PCa metastasis rema...
Effect of p53 gene mutation with loss of function on the expression of genes and proteins involved in cell proliferation [0.03%]
p53基因失活突变对增殖相关基因和蛋白质表达的影响研究
Gyeong Hee Kim,Moon-Moo Kim
Gyeong Hee Kim
The tumor suppressor gene TP53 plays a vital role in preserving genomic integrity by regulating cell cycle progression, DNA repair mechanisms, and apoptosis. This study aims to examine how CRISPR/Cas9-induced loss-of-function mutations in t...
The oncogenic role of U2AF2/HKDC1 cascade in colorectal cancer by promoting cancer cell glycolysis and malignant phenotypes [0.03%]
U2AF2/HKDC1串珠体在结直肠癌中的致癌作用：通过促进癌细胞糖酵解和恶性表型所致
Wenjuan Feng,Mingfeng Wu,Hanyang Zou et al.
Wenjuan Feng et al.
Background: Dysregulation of hexokinase domain component 1 (HKDC1), a central regulator of glucose metabolism, plays a pathogenic role in colorectal cancer (CRC). The current research investigated the RNA-binding protein ...
SPDEF-mediated BIRC5 transcriptional activation enhances non-small cell lung cancer progression [0.03%]
SPDEF介导的BIRC5转录激活促进非小细胞肺癌进展
Zhixiong Qiao,Zhiping Lv,Xuyang Song et al.
Zhixiong Qiao et al.
Background: SAM-pointed domain-containing ETS transcription factor (SPDEF), an ETS family transcription factor (TF), functions as a tumor-promoting factor in non-small cell lung cancer (NSCLC). However, the precise mechan...
Deciphering the structural and functional impact of interleukin-3 (IL-3) variants: Insights from site-directed mutagenesis, computational modeling, molecular dynamics simulations, and implications for anticancer therapies and immune regulation [0.03%]
解读白细胞介素-3（IL-3）变异体的结构和功能影响：定点突变、计算建模、分子动力学模拟及其在抗癌治疗和免疫调节中的启示
Allah Rakha Yaseen,Uzma Nisar,Munir Ahmad et al.
Allah Rakha Yaseen et al.
Interleukin-3 (IL-3) is a pivotal cytokine in immune regulation, making it a compelling target for therapeutic intervention in immune-related disorders. This study employs an integrative computational approach, combining site-directed mutag...