LncRNA UCA1 could regulate the progression of neuropathic pain by regulating miR-135a-5p [0.03%]
长链非编码RNA UCA1通过调节miR-135a-5p参与神经病理性疼痛的发展
Bingbing Wu,Xiaogang Zhou
Bingbing Wu
Background: Neuropathic pain (NPP) is known as a common neurological disease with high incidence rate. The present work focused on the roles of long non-coding RNA urothelial carcinoma antigen 1(LncRNA UCA1) in NPP and th...
Hsa-miR-1269a up-regulation fosters the malignant progression of esophageal squamous cell carcinoma via targeting FAM46C [0.03%]
miR-1269a通过靶向FAM46C促进食管鳞癌恶性进展
Yuefeng Ma,Xin Xing,Chuantao Cheng et al.
Yuefeng Ma et al.
Esophageal squamous cell carcinoma (ESCC) is a malignancy of the alimentary tract resulting in death worldwide. The role and underlying mechanism of hsa-miR-1269a in the progression of ESCC remain unclear. In this study, hsa-miR-1269a was s...
Uncommon variants detected via hereditary cancer panel and suggestions for genetic counseling [0.03%]
罕见突变的检测及其遗传咨询建议
Zeynep Özdemir,Ezgi Çevik,Ömür Berna Çakmak Öksüzoğlu et al.
Zeynep Özdemir et al.
Objective: Hereditary cancer syndromes constitute 5-10% of all cancers. The development of next-generation sequencing technologies has made it possible to examine many hereditary cancer syndrome-causing genes in a single ...
Identification and validation of long noncoding RNA AC083900.1 and RP11-283C24.1 for prediction of progression of osteosarcoma [0.03%]
长链非编码RNA AC083900.1和RP11-283C24.1在预测骨肉瘤进展中的鉴定与验证
Liangkun Huang,Wenyi Jin,Yucheng Bao et al.
Liangkun Huang et al.
Background: The role of cuproptosis, an emerging cell death pathway that makes a remarkable contribution to tumor progression, remains elusive in osteosarcoma (OS), in addition to its regulator, including long-no-coding R...
Bioinformatics analysis to identify breast cancer-related potential targets and candidate small molecule drugs [0.03%]
乳腺癌相关潜在靶点及候选小分子药物的生物信息学分析
Huan Hong,Haifeng Chen,Junjie Zhao et al.
Huan Hong et al.
Objective: The purpose of this study is to identify potential targets associated with breast cancer and screen potential small molecule drugs using bioinformatics analysis. ...
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway [0.03%]
下调小鼠脊髓CAV-1可能通过抑制ERK/CREB通路缓解骨癌痛
Jianyun Ge,Jie Song,Bo Sun et al.
Jianyun Ge et al.
Background: This study aimed to assess the potential function of Caveolin-1 (CAV-1) in mice with bone cancer pain. Method: Using a mice...
Oxidative and DNA damage in obese patients undergoing bariatric surgery: A one-year follow-up study [0.03%]
肥胖患者代谢手术治疗一年的氧化及DNA损伤的纵向研究
Anna Chiaramonte,Serena Testi,Caterina Pelosini et al.
Anna Chiaramonte et al.
The pathogenesis of obesity and related comorbidities has long been associated with oxidative stress. The excess of adipose tissue contributes to the production of free radicals that sustain both a local and a systemic chronic inflammatory ...
PARP deficiency causes hypersensitivity to Taxol through oxidative stress induced DNA damage [0.03%]
聚腺苷二磷酸核糖聚合酶缺乏通过氧化应激诱导的DNA损伤对紫杉醇敏感化
Junko Maeda,Ben Jepson,Kohei Sadahiro et al.
Junko Maeda et al.
Taxol is an antitumor drug derived from the bark of the Pacific Yew tree that inhibits microtubule disassembly, resulting in cell cycle arrest in late G2 and M phases. Additionally, Taxol increases cellular oxidative stress by generating re...
MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2 [0.03%]
微RNA-30a-5p通过调控CBX2抑制食管癌细胞行为
Luxing Peng,Xinjun Huang,Defeng Qing et al.
Luxing Peng et al.
Background: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Methods: Research objects wer...
LncRNA CRNDE is involved in the pathogenesis of renal fibrosis by regulating renal epithelial cell mesenchymal-epithelial transition via targeting miR-29a-3p [0.03%]
长链非编码RNA CRNDE通过靶向miR-29a-3p调节肾小管上皮细胞的上皮间质转化从而参与肾纤维化的发生发展
Min Zhao,Nan Li,Cheng Wan et al.
Min Zhao et al.
Results of previous studies suggested that renal fibrosis and epithelial-mesenchymal transition (EMT) plays an important role in the process of renal fibrosis, but the underlying mechanism remains unclear. Long coding RNA (lncRNA) CRNDE has...