Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway [0.03%]
下调小鼠脊髓CAV-1可能通过抑制ERK/CREB通路缓解骨癌痛
Jianyun Ge,Jie Song,Bo Sun et al.
Jianyun Ge et al.
Background: This study aimed to assess the potential function of Caveolin-1 (CAV-1) in mice with bone cancer pain. Method: Using a mice...
Oxidative and DNA damage in obese patients undergoing bariatric surgery: A one-year follow-up study [0.03%]
肥胖患者代谢手术治疗一年的氧化及DNA损伤的纵向研究
Anna Chiaramonte,Serena Testi,Caterina Pelosini et al.
Anna Chiaramonte et al.
The pathogenesis of obesity and related comorbidities has long been associated with oxidative stress. The excess of adipose tissue contributes to the production of free radicals that sustain both a local and a systemic chronic inflammatory ...
PARP deficiency causes hypersensitivity to Taxol through oxidative stress induced DNA damage [0.03%]
聚腺苷二磷酸核糖聚合酶缺乏通过氧化应激诱导的DNA损伤对紫杉醇敏感化
Junko Maeda,Ben Jepson,Kohei Sadahiro et al.
Junko Maeda et al.
Taxol is an antitumor drug derived from the bark of the Pacific Yew tree that inhibits microtubule disassembly, resulting in cell cycle arrest in late G2 and M phases. Additionally, Taxol increases cellular oxidative stress by generating re...
MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2 [0.03%]
微RNA-30a-5p通过调控CBX2抑制食管癌细胞行为
Luxing Peng,Xinjun Huang,Defeng Qing et al.
Luxing Peng et al.
Background: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Methods: Research objects wer...
LncRNA CRNDE is involved in the pathogenesis of renal fibrosis by regulating renal epithelial cell mesenchymal-epithelial transition via targeting miR-29a-3p [0.03%]
长链非编码RNA CRNDE通过靶向miR-29a-3p调节肾小管上皮细胞的上皮间质转化从而参与肾纤维化的发生发展
Min Zhao,Nan Li,Cheng Wan et al.
Min Zhao et al.
Results of previous studies suggested that renal fibrosis and epithelial-mesenchymal transition (EMT) plays an important role in the process of renal fibrosis, but the underlying mechanism remains unclear. Long coding RNA (lncRNA) CRNDE has...
Efficient, robust, and versatile fluctuation data analysis using MLE MUtation Rate calculator (mlemur) [0.03%]
一种高效、稳健且通用的波动数据应用最大似然估算法分析工具(MLE MUtation Rate calculator，简称mlemur)
Krystian Łazowski
Krystian Łazowski
The fluctuation assay remains an important tool for analyzing the levels of mutagenesis in microbial populations. The mutant counts originating from some average number of mutations are usually assumed to obey the Luria-Delbrück distributi...
XRCC8 mutation causes hypersensitivity to PARP inhibition without Homologous recombination repair deficiency [0.03%]
XRCC8突变导致对PARP抑制剂的高敏感性而不伴有同源重组修复功能缺陷
Junko Maeda,Jeremy S Haskins,Takamitsu A Kato
Junko Maeda
PARP inhibitors inflict severe toxicity to homologous recombination (HR) repair deficient cells because DNA damages induced by PARP inhibition result in lethal DNA double strand breaks in the absence of HR repair during DNA replication. PAR...
Mutagenesis induced by protonation of single-stranded DNA is linked to glycolytic sugar metabolism [0.03%]
单链DNA质子化的诱变作用与糖酵解的糖代谢有关
Suzana P Gelova,Kin Chan
Suzana P Gelova
Mutagenesis can be thought of as random, in the sense that the occurrence of each mutational event cannot be predicted with precision in space or time. However, when sufficiently large numbers of mutations are analyzed, recurrent patterns o...
Analysis of tafazzin and deoxyribonuclease 1 like 1 transcripts and X chromosome sequencing in the evaluation of the effect of mosaicism in the TAZ gene on phenotypes in a family affected by Barth syndrome [0.03%]
TAZZ基因镶嵌变异对Barth综合征家系表型影响的评估：tafazzin和脱氧核糖核酸酶1样1转录本分析以及X染色体测序
Teresa Płatek,Maria Sordyl,Anna Polus et al.
Teresa Płatek et al.
Barth syndrome is a rare disease affecting mitochondria structure and function in males. In our previous study, we have shown a new mutation (c.83T>A, p.Val28Glu) in the TAZ gene in two affected patients with congenital cardiomyopathy. Furt...
Ian Crespo-Orta,Carmen Ortiz,Jarline Encarnación et al.
Ian Crespo-Orta et al.
Objective: Examine whether DNA repair capacity (DRC) levels are associated with body mass index (BMI) in adult women. Design and participants: ...