Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications [0.03%]
遗传性癌症检测中RAD51C、RAD51D和BRIP1单等位基因变异的谱系：变异频谱及临床咨询意义
Zeynep Özdemir-Pehlivan,Afife Büke,Ezgi Çevik-Demir et al.
Zeynep Özdemir-Pehlivan et al.
Defects in homologous recombination repair genes contribute to hereditary cancer susceptibility beyond BRCA1 and BRCA2, yet clinical interpretation of intermediate-penetrance genes remains challenging. We retrospectively evaluated unrelated...
Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis [0.03%]
一种全面的在线分析方法预测TP53基因相关肝细胞癌生物标志物
Amna Saeed,Riffat Iqbal,Mohammad Rahim et al.
Amna Saeed et al.
TP53 mutation is one of the most frequently altered genetic variants leading to hepatocellular carcinoma (HCC). Single nucleotide polymorphisms (SNPs) in this gene play a crucial role in predicting the risk of HCC development. This study ai...
IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors [0.03%]
IDH1突变通过上调缺氧诱导因子1α促进胶质瘤血管生成
Muhammed Deniz Oksal,Turker Kilic,Timucin Avsar
Muhammed Deniz Oksal
Glial tumors are the most common malignant brain tumors, and IDH1 serves as an important diagnostic and prognostic molecular marker in gliomas. The mutation status of IDH1 influences prognosis, patient survival, and treatment response in gl...
Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling [0.03%]
靶向基因沉默介导的食管癌中过表达的致癌基因：来自结合亲和力和热力学分析的见解
Sabnam Nasrin Choudhury,Tarikul Huda Mazumder,Sahidul Saikia et al.
Sabnam Nasrin Choudhury et al.
Esophageal cancer (ESCA) ranks among the most lethal malignancies worldwide, with late-stage diagnosis, poor prognosis, and limited treatment options contributing to its high mortality. MicroRNAs (miRNAs), short non-coding RNAs with gene-si...
The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer [0.03%]
Polygonum cuspidatum中的活性成分芦丁通过靶向COL3A1增强CD8⁺ T细胞的杀伤作用从而抑制胃癌进展
Yunhai Wei,Huancen Guo,Wenjing Hu et al.
Yunhai Wei et al.
Background: Gastric cancer (GC) is a highly prevalent gastrointestinal malignancy with poor prognosis worldwide, and its initiation and progression are closely associated with tumor immune escape. Polygonum cuspidatum, a ...
E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT [0.03%]
E2F1通过NEK2介导的Wnt/β-catenin和Notch激活及上皮间质转化促进肝癌恶性表型
Lingju Hong,Shaoying Ke,Shaoze Lin et al.
Lingju Hong et al.
Background: Hepatocellular carcinoma (LIHC) is the most common primary liver cancer, with high recurrence and metastasis rates, and its molecular mechanisms remain incompletely understood. ...
Exploring Taq polymerase induced mutations in part of BRAF exon 15 by sequencing and mutation enrichment [0.03%]
测序及变异增强法探讨Taq聚合酶诱导的BRAF外显子15部分序列突变
Per O Ekstrøm,Sigve Nakken,Eivind Hovig
Per O Ekstrøm
The polymerase chain reaction (PCR) is a fundamental technique in molecular biology, enabling the amplification of specific DNA sequences for various applications. Despite its utility, the fidelity of DNA polymerases used during amplificati...
Deubiquitinase USP10 regulates angiotensin II-induced renal fibrosis by modulating the expression of TLR4 [0.03%]
去泛素化酶USP10通过调节TLR4的表达调控血管紧张素II诱导的肾纤维化
Rong Wang,Yanjun Shen,Jiaqi Shi et al.
Rong Wang et al.
Background: Diabetic kidney disease (DKD) is one of the main causes of chronic kidney disease (CKD). There is evidence suggesting that the upregulation of Toll-like receptor 4 (TLR4) can exacerbate the progression of diab...
Maternal exposure to sucrose and maltodextrin alters metabolism and genotoxicity in mice offspring [0.03%]
母体接触蔗糖和麦芽糊精可改变后代小鼠的代谢及致突变性
Marina Lummertz Magenis,Whayne Alves Alecrim,Otávio Lúcio Possamai et al.
Marina Lummertz Magenis et al.
Early metabolic events during the intrauterine period can increase susceptibility to chronic diseases in adulthood. Fetal and neonatal nutrition rich in sugars may lead to disorders such as obesity, insulin resistance, and diabetes. This st...
Characterization of pathogenic missense mutations in nuclear encoded mitochondrial dynamin -1 like protein [0.03%]
核编码线粒体动力蛋白-1样蛋白质致病性错义突变的特征分析
Kaniha Sivakumar,Nihala Sidhic,Usha Subbiah et al.
Kaniha Sivakumar et al.
Background: The DNM1L gene encodes the dynamin-related protein, Drp1, essential for mitochondrial fission. Impaired mitochondrial division contributes to cardiovascular, neurodegenerative, and metabolic disorders. This st...