The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies [0.03%]
抗中性粒细胞胞浆抗体的生物学、致病作用、临床意义及待解决问题
Giacomo Ramponi,Marco Folci,Maria De Santis et al.
Giacomo Ramponi et al.
Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies, predominantly IgG, involved in the pathogenesis of several autoimmune disorders, detected either through indirect immunofluorescence or enzyme-linked immunosorbent...
Pathophysiologic role of Interleukin-33/ST2 in Sjögren's syndrome [0.03%]
白细胞介素-33/ST2在Sjogren综合征的病理生理作用
Muhammad S Soyfoo,Charles Nicaise
Muhammad S Soyfoo
Interleukin-33 (IL-33) is a member of the IL-1 family and has dual functions as a nuclear factor as well as a cytokine. The pivotal role of IL-33 as an active player contributing to aberrant local and systemic damage has been highlighted in...
Alessandro Conforti,Ilenia Di Cola,Viktoriya Pavlych et al.
Alessandro Conforti et al.
Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the systemic inflammatory process may involve other tissues and organs. Many extra-articular manifestations are recognized, which are related to worse ...
An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions [0.03%]
NF-κB介导的类风湿性关节炎发病机制概览及其配体RANKL和相关营养干预研究
Desislava Daisy Ilchovska,Dr Michelle Barrow
Desislava Daisy Ilchovska
Nuclear Factor Kappa-Β (NF-kB) is recognized as one of the main inflammatory pathways in the Autoimmune Disease (AD) Rheumatoid Arthritis (RA), which exhibits high levels of inflammatory cytokines such as IL-1, TNFa and IL-6 linked to bone...
Efficacy and safety of rituximab in treating patients with Neuromyelitis optica spectrum disorder (NMOSD): A systematic review and meta-analysis [0.03%]
利妥昔单抗治疗视神经脊髓炎谱系障碍疗效和安全性的系统评价和 meta 分析
Omid Mirmosayyeb,Vahid Shaygannejad,Mahdi Barzegar et al.
Omid Mirmosayyeb et al.
Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis: A systematic literature review [0.03%]
利妥昔单抗治疗嗜酸性肉芽肿伴聚动脉炎的系统文献综述
Mitsuhiro Akiyama,Yuko Kaneko,Tsutomu Takeuchi
Mitsuhiro Akiyama
Objective: We investigated the effectiveness of rituximab (an anti-CD20 monoclonal antibody) in patients with eosinophilic granulomatosis with polyangiitis (EGPA). ...
Carla Varrica,Helena Sofia Dias,Catarina Reis et al.
Carla Varrica et al.
Systemic sclerosis (SSc) is considered one of the most challenging and difficult to treat among rheumatic disorders, due to its severity, multiorgan manifestation and different outcomes. It manifests fibrosis in different organs, mostly in ...
Targeted therapies in interstitial lung disease secondary to systemic autoimmune rheumatic disease. Current status and future development [0.03%]
系统性自身免疫性疾病相关间质性肺病的靶向治疗：现状及未来展望
Foteini V Karakontaki,Efstratios S Panselinas,Vlasios S Polychronopoulos et al.
Foteini V Karakontaki et al.
Autoimmune rheumatic diseases (ARD) are characterized by systemic manifestations and multiple organ involvement, including the lung. Interstitial Lung Disease (ILD) is a cardinal manifestation of lung involvement in patients with ARD and is...
Rheumatic heart disease: A review of the current status of global research activity [0.03%]
风湿性心脏病：全球研究现状综述
Leanne M Dooley,Tarek B Ahmad,Manisha Pandey et al.
Leanne M Dooley et al.
Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes (Group A Streptococcus, Strep A). The pathogenesis of ARF and RHD is...
B cell activating factor (BAFF): Structure, functions, autoimmunity and clinical implications in Systemic Lupus Erythematosus (SLE) [0.03%]
B细胞活化因子（BAFF）：结构、功能、自身免疫和系统性红斑狼疮（SLE）的临床意义
Tamara Möckel,Fabio Basta,Julia Weinmann-Menke et al.
Tamara Möckel et al.
The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion. BAFF expression is closely linked with autoimmunity and is enhanced by gene...