The BAFF/APRIL system at the crossroads of B cell memory and autoimmune relapse: Implication into the therapeutic strategies [0.03%]
BAFF/APRIL系统在B细胞免疫记忆和自身免疫复发的十字路口：对治疗策略的影响
Chengqian Liao,Yu Chen,Cong Ye et al.
Chengqian Liao et al.
B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) exert their functions by engaging distinct receptors, B cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI), and BAFF receptor (BAFFR...
Contribution of intestinal mucosa to the disease mechanisms of Spondyloarthritis: Unlocking new insights through bioengineered tissue models [0.03%]
肠黏膜在脊柱关节炎疾病机制中的作用：通过生物工程技术模型获得新认识
Gerlando Natalello,Enrico De Lorenzis,Maria Antonietta D&#x;Agostino et al.
Gerlando Natalello et al.
Spondyloarthritis (SpA) represents a spectrum of chronic inflammatory rheumatic disorders with similar articular and extra-articular features and a complex pathogenesis stemming from the interplay between genetics, environmental triggers, a...
Expert perspectives on Myalgic encephalomyelitis/chronic fatigue syndrome - Insights from the 3rd International Conference of the Charité Fatigue Center [0.03%]
肌痛性脑脊髓炎/慢性疲劳综合征专家视角——来自Charité疲劳中心第三届国际会议的见解
Annick Fehrer,Lara Windzio,Simon Schoening et al.
Annick Fehrer et al.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystemic disorder mostly triggered by viral infections, with core symptoms including post-exertional malaise (PEM), fatigue, pain, and cognitive dysfunction. Its...
Isolated antineutrophil cytoplasmic antibody-associated interstitial lung disease: A systematic review of an emerging condition [0.03%]
孤立的抗中性粒细胞胞浆抗体相关间质性肺病：一种新兴疾病的系统评价研究
Javier Narváez,Pol Maymó
Javier Narváez
Objective: To summarise the clinical characteristics, radiological and histopathological features, treatment approaches, and outcomes of isolated antineutrophil cytoplasmic antibody-associated interstitial lung disease (A...
VEXAS syndrome in adults: A narrative review of genomic pathogenesis, multisystem phenotypes, diagnostic algorithms, and emerging therapeutic strategies [0.03%]
成人VEXAS综合征的基因组发病机制、多系统表型、诊断算法和新兴治疗策略文献综述
Antonio Vitale,Carlos Cifuentes-González,Martina Gentile et al.
Antonio Vitale et al.
Aim: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a recently defined adult-onset autoinflammatory disorder caused by somatic mutations in the UBA1 gene. This narrative review synthesizes cu...
Sébastien Blaise,Sylviane Muller
Sébastien Blaise
Autophagy is a highly conserved lysosomal recycling pathway that couples nutrient availability to cellular quality control and immune regulation. Accumulating evidence identifies autophagy as a central mechanistic interface through which di...
Chinese recommendations for the diagnosis and management of non-radiographic axial spondyloarthritis [0.03%]
中国非放射学轴向脊柱关节炎诊断与治疗建议
Sheng-Ming Dai,Huji Xu,Yan Zhao;Committee for “Guidelines for the Diagnosis and Treatment of Non-Radiographic Axial Spondyloarthritis” et al.
Sheng-Ming Dai et al.
Background: The term of non-radiographic axial spondyloarthritis (nr-axSpA) has stimulated a number of practice-changing developments, but the meaning of nr-axSpA has not been well understood by clinicians, including rheu...
The effect of Nintedanib on KL-6 levels in patients with interstitial lung disease: A systematic review and meta-analysis [0.03%]
奈拉替尼对间质性肺病患者KL-6水平影响的系统评价和 meta 分析
Maria Boutel,Elpida Skouvaklidou,Styliani Partalidou et al.
Maria Boutel et al.
Background: Interstitial Lung Diseases (ILDs) are pulmonary disorders with high levels of morbidity and mortality. Anti-fibrotic treatment halts ILD progression. Krebs von den Lungen-6 (KL-6) is a circulating glycoprotein...
Angiogenic imbalance and endothelial dysfunction in the placenta in antiphospholipid syndrome [0.03%]
抗磷脂综合征胎盘血管生成失衡及内皮功能障碍
A Martirosyan,E Kriegova,G Manukyan
A Martirosyan
Placental vascular development depends on the tightly orchestrated interplay of vasculogenesis, angiogenesis, and vascular remodeling to sustain efficient maternal-fetal exchange across gestation. In obstetric antiphospholipid syndrome (APS...
Targeting autoimmunity: Phosphodiesterase inhibitors as immunomodulators-a review of current insights and future direction [0.03%]
靶向自身免疫：磷酸二酯酶抑制剂作为免疫调节剂的现状及未来展望综述
Anna Bazsó,Péter Szodoray,Yehuda Shoenfeld et al.
Anna Bazsó et al.
Phosphodiesterase (PDE) inhibitors are a class of pharmacological agents that regulate immune and vascular function by controlling the intracellular concentration of key second messengers. By modulating cyclic nucleotide signaling, particul...