Dynamic profiling in inflammatory Bowel disease: A manifesto for personalized care [0.03%]
炎症性肠病的动态评估：个性化治疗宣言
Giuseppe Privitera,Mariangela Allocca,Luca Antonioli et al.
Giuseppe Privitera et al.
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a heterogeneous chronic condition whose clinical management has been advanced by the availability of molecularly targeted therapies. Despite this prog...
Bispecific T-cell engagers in autoimmune diseases: mechanisms of action, clinical evidence challenges, and therapeutic perspectives [0.03%]
双特异性T细胞衔接剂在自身免疫性疾病中的作用机制、临床证据挑战和治疗前景
Marion Larue,Samuel Bitoun,Julien Zuber et al.
Marion Larue et al.
Bispecific T-cell engagers (TCEs) represent a new generation of immunotherapies designed to redirect cytotoxic T lymphocytes toward specific cellular targets, particularly B cells and their differentiated progeny. Initially developed in hem...
Innate immunity and biomarkers of multiple sclerosis relapse versus remission [0.03%]
天然免疫和多发性硬化症复发与缓解的生物标志物
Meltem Karadeniz,Robb Wesselingh,Padmakrishnan C Jayakrishnan et al.
Meltem Karadeniz et al.
Multiple sclerosis (MS) is a neurodegenerative and inflammatory disease presenting most commonly in its relapsing and remitting form, whereby a relapse is defined as an acute exacerbation of disease activity associated with worsening disabi...
Anti-CD52 therapy of rheumatic diseases: Revisited in the era of immune reset [0.03%]
风湿病的抗CD52治疗：免疫重建时代的重新审视
Fadi Hassan,John D Isaacs,Mohammad E Naffaa
Fadi Hassan
Alemtuzumab is a humanized monoclonal antibody targeting CD52, a glycosylphosphatidylinositol-anchored surface antigen broadly expressed on lymphocytes and other immune cells. Although currently approved for multiple sclerosis and used in s...
Effects of vitamin D supplementation on patients with systemic lupus erythematosus: A systematic review and meta-analysis [0.03%]
维生素D补充对系统性红斑狼疮患者的影响：一项系统综述和荟萃分析
Jiale Lu,Qingmiao Zhu,Jiaxun Yu et al.
Jiale Lu et al.
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease frequently associated with vitamin D insufficiency. Vitamin D supplementation has been proposed as a potential adjunctive therapeutic strategy...
Predicting the course: Real-world trajectories toward minimal disease activity in psoriatic arthritis [0.03%]
预测病程：银屑病关节炎最小疾病活动度的现实轨迹分析
Mauro Fatica,Fabio Massimo Perrotta,Paola Conigliaro et al.
Mauro Fatica et al.
Objectives: To investigate real-world trajectories toward minimal disease activity (MDA) in psoriatic arthritis (PsA) patients starting their first biologic or targeted synthetic DMARD (bDMARD/tsDMARD) and identify baseli...
Effects of biologics and small-molecule inhibitors on lipid profiles in patients with psoriasis or psoriatic arthritis: An analysis of current evidence [0.03%]
生物制剂和小分子抑制剂对银屑病或银屑病关节炎患者血脂谱的影响：现有证据分析
Miao Zhang,Pengbo Gao,Yumei Li et al.
Miao Zhang et al.
Importance: Available evidence reveals markedly divergent metabolic signatures across biologics and small-molecule inhibitors, highlighting the need for further investigations. ...
Liang Jin,Chenxu Yang,Jianping Gan et al.
Liang Jin et al.
Sjögren's Disease (SjD) is a chronic autoimmune disease characterized by exocrine glandular lymphocyte infiltration and functional damage, with a complex pathogenesis and immune cell imbalance as a key driver. Myeloid-derived suppressor ce...
The risk of allergy in patients with IgG4-related disease: A systematic review and meta-analysis [0.03%]
IgG4相关疾病患者过敏风险的系统评价和meta分析
Zhan Li,Jingdi Zhang,Honglin Xu et al.
Zhan Li et al.
Background: IgG4-related disease (IgG4-RD) is an immune-mediated condition characterized by multi-organ involvement. Substantial evidence suggests a close link between allergy and IgG4-RD, supported by the high prevalence...
Prevalence and clinical significance of anti-NOR90 antibodies in systemic sclerosis: Results from a multicentre cohort and systematic literature review [0.03%]
抗NOR90抗体在系统性硬化症中的流行率及临床意义：多中心队列和系统文献回顾的结果
Javier Narváez,Miguel Ángel González-Gay,Francisco Morandeira et al.
Javier Narváez et al.
Objective: To evaluate the prevalence and clinical associations of anti-Nucleolar Organizer Region 90 (anti-NOR90) antibodies in patients with systemic sclerosis (SSc). ...