Pathological reprogramming of innate immune cells drives resistance to biologics in inflammatory bowel diseases [0.03%]
炎症性肠病中固有免疫细胞的病理学重编引起对生物制剂的耐药性
Jun Diao,Hui Cao,Jing Zhou et al.
Jun Diao et al.
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic immune-mediated disorder characterized by persist ent intestinal inflammation. With a rising global incidence, IBD poses a signifi...
Racial minorities are under-represented in SLE clinical trials: A systematic review and meta-analysis [0.03%]
系统评价与meta分析：狼疮临床试验中各族裔样本比例失调
Matthew A Turk,Jordan Hausman,Janet E Pope
Matthew A Turk
Background: With numerous emerging treatments for systemic lupus erythematosus (SLE), it is imperative that clinical trials include diverse populations reflective of those with SLE, especially active disease. Epidemiologi...
Depression in mastocytosis: A neglected dimension of a clonal mast cell disease [0.03%]
基于克隆性肥大细胞增多症的抑郁症：被忽视的一维
Petr Heneberg
Petr Heneberg
Depression is a highly prevalent but underrecognized comorbidity in mastocytosis, a clonal mast cell disorder characterized by aberrant proliferation and activation of mast cells. Historically, depression in patients with mastocytosis was c...
Global and regional epidemiology of psoriatic arthritis in general population: A comprehensive systematic analysis and modelling study [0.03%]
一般人群中的银屑病关节炎的全球和区域流行病学：全面系统分析与建模研究
Jingnan Xu,Zijian Kang,Yu Du et al.
Jingnan Xu et al.
Background: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis, which is refractory and recurrent, affecting patients' lives and work seriously. Therefore, measuring the frequency of disease ...
Subtype-specific mortality in idiopathic inflammatory myopathies: A hospital-based cohort [0.03%]
中国住院肌炎患者的病死率及影响因素：以皮肌炎和包涵体肌炎预后不良为例
Aurore Larrauffie,Chloé Bost,Claire Barrier et al.
Aurore Larrauffie et al.
Introduction: The aim of our study is to compare mortality rates, causes of death and associated risk factors for idiopathic inflammatory myopathies (IIM) and their various subtypes in a hospital-based cohort, specially I...
Iron, autoimmunity, and thrombosis: Exploring sex-specific interactions [0.03%]
铁、自身免疫和血栓形成：探索性别特异性相互作用
Roberta Gualtierotti,Luca Valenti
Roberta Gualtierotti
Iron is essential for oxygen delivery, energy production and several metabolic processes, but it also plays a crucial role in modulating immunity and coagulation. Impaired iron availability can contribute to both immune dysregulation and a ...
The Interleukin-17-T helper 17 axis in primary sclerosing cholangitis: A narrative review of an emerging pathogenic frontier [0.03%]
原发性硬化性胆管炎中白细胞介素-17-Th17轴：对新兴病理前沿的叙述性综述
Amera Elzubeir,Meha Patel,Simon Rushbrook
Amera Elzubeir
Interleukin-17 (IL-17) and IL-17+ secretory cells, including T helper 17 (Th17) cells play pivotal roles in autoimmune diseases such as psoriasis. Emerging evidence implicates the IL-17 pathway in primary sclerosing cholangitis (PSC), a chr...
Phage ImmunoPrecipitation sequencing (PhIP-Seq) in autoimmunity research: From high-resolution epitope mapping to multi-omics integration [0.03%]
噬菌体免疫沉淀测序（PhIP-seq）在自身免疫研究中的应用：从高分辨率表位图谱绘制到多组学整合
Rui Yu,Ruijing Lu,Chiyuan Xue et al.
Rui Yu et al.
Autoimmune diseases (AIDs) affect 5-10% of the global population, yet effective diagnosis and treatment remain challenging due to their complexity and heterogeneity. Autoantibodies serve as crucial biomarkers for disease classification and ...
Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) guidelines on the use of autoantibody tests in the diagnosis of autoimmune liver diseases [0.03%]
意大利临床病理和实验医学学会(SIPMeL)关于自身抗体检测在自身免疫性肝病诊断中应用的指导方针
Maria Concetta Sorrentino,Danilo Villalta,Teresa Carbone et al.
Maria Concetta Sorrentino et al.
Autoimmune liver diseases (AILDs) are considered rare conditions, though the frequency of their diagnosis is increasing thanks to the introduction of new diagnostic tests and improvements in analytical technologies. In clinical practice, in...
Idiopathic granulomatous mastitis as an autoimmune disease: A review of immunopathogenesis and therapeutic response [0.03%]
自身免疫性疾病的特发性肉芽肿性乳腺炎：免疫病理发生及治疗反应的综述
Luke K Bergstrom,Diana M Jaen,Antonio Lamelas et al.
Luke K Bergstrom et al.
Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory breast disease that predominantly affects parous women of reproductive age, with higher incidence in women of Latina, Middle Eastern, Asian, and African descent. Although its...