The emerging concept of ANCA-associated vasculitis related to inborn errors of immunity [0.03%]
与先天性免疫缺陷相关的血管炎相关抗中性粒细胞胞浆抗体的新概念
Clément Triaille,Benjamin Terrier,Alice Hadchouel et al.
Clément Triaille et al.
ANCA-associated vasculitis (AAV) is a group of rare small vessels vasculitis that preferentially affect the kidneys, lungs and upper airways. Although the detailed pathophysiology remains unclear, genetic background has been shown to play a...
Coffee consumption and risk of multiple sclerosis: A systematic review and meta-analysis [0.03%]
咖啡摄入与多发性硬化症风险的相关性：系统回顾和荟萃分析
Mehrad Amirnia,Khazar Raeisnia,Hamidreza Ashayeri et al.
Mehrad Amirnia et al.
Background: Multiple Sclerosis (MS) is an immune-mediated disease with miscellaneous etiological origins. Given caffeine's neuroprotective and anti-inflammatory attributes and its potential influence on MS risk, and to ad...
Rebalancing redox homeostasis: A pivotal regulator of the cGAS-STING pathway in autoimmune diseases [0.03%]
氧化还原稳态的再平衡：自身免疫性疾病中cGAS-STING通路的关键调节因子
Yuchen Zhao,Tianhao Xu,Zhaoshun Wu et al.
Yuchen Zhao et al.
Autoimmune diseases (ADs) arise from the breakdown of immune tolerance to self-antigens, leading to pathological tissue damage. Proinflammatory cytokine overproduction disrupts redox homeostasis across diverse cell populations, generating o...
The role of double-negative B cells in the pathogenesis of systemic lupus erythematosus [0.03%]
双阴性B细胞在系统性红斑狼疮发病机制中的作用
Xinying Qiu,RuiFan Wen,Feifeng Wu et al.
Xinying Qiu et al.
B cells are essential to the pathophysiology of systemic lupus erythematosus (SLE), a chronic autoimmune illness. IgD-CD27-double negative B cells (DNB cells) are one of the aberrant B cell subsets linked to SLE that have attracted much sci...
Janus kinase inhibitors for psoriatic arthritis: Evidence from a systematic review and network meta-analysis [0.03%]
基于系统性回顾和网络meta分析的银屑病关节炎 janus 激酶抑制剂疗效评估
Sotirios G Tsiogkas,Arriana Gkouvi,Katerina Maria Kontouli et al.
Sotirios G Tsiogkas et al.
Psoriatic arthritis (PsA) constitutes a heterogeneous disease. Diagnosis is commonly made by identifying joint inflammation, dactylitis, enthesitis, or axial spine involvement in cutaneous or nail psoriasis. Janus kinases (JAKs) are intrace...
Macrophage polarization regulates the pathogenesis and progression of autoimmune diseases [0.03%]
巨噬细胞极化调节自身免疫疾病的发病和进展
Siwen Wu,Shubi Zhao,Lei Hai et al.
Siwen Wu et al.
Macrophages are integral components of the innate immune system, present in nearly all tissues and organs throughout the body. They exhibit a high degree of plasticity and heterogeneity, participating in immune responses to maintain immune ...
The role of interleukin inhibitors in the treatment of hidradenitis suppurativa; a systematic review of clinical trials [0.03%]
白细胞介素抑制剂在汗腺炎治疗中的作用；临床试验系统性回顾
Nazila Heidari,Amirhossein Heidari,Sara Eghbali et al.
Nazila Heidari et al.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that presents significant treatment challenges. Recent advancements have enhanced our understanding of its pathophysiology, leading to the development of novel therapeuti...
Autophagy in myositis, a dysregulated pathway, and a target for therapy [0.03%]
自身炎症中自噬的紊乱及其作为治疗靶点的作用
A S Kamalanathan,Vikas Agarwal,Laura Talamini et al.
A S Kamalanathan et al.
Corticosteroids and immunosuppressants are the mainstay of therapy for idiopathic inflammatory myopathies (IIMs). However, a significant therapeutic challenge extends beyond mitigating inflammation with these agents to achieving meaningful ...
The entrenchment of NLRP3 inflammasomes in autoimmune disease-related inflammation [0.03%]
NLRP3炎症小体在自身免疫性疾病相关炎症中根除的作用
Valeria Carnazzo,Donato Rigante,Giuliana Restante et al.
Valeria Carnazzo et al.
Autoinflammation and autoimmunity are almost "opposite" phenomena characterized by chronic activation of the immune system, 'innate' in the first and 'adaptive' in the second, leading to inflammation of several tissues with specific protean...
The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases [0.03%]
CRISPR-Cas9和CRISPR干扰技术在自身免疫病治疗中的作用研究进展
Zahra Khademi,Negar Mottaghi-Dastjerdi,Hamed Morad et al.
Zahra Khademi et al.
Autoimmune disorders can be described as inappropriate immune responses directed against self-antigens, which account for substantial healthcare concerns around the world. Immunosuppression or immune modulation are the main therapeutic moda...