Systemic lupus erythematosus and the gut microbiome: To look forward is to look within - A systematic review and narrative synthesis [0.03%]
系统性红斑狼疮与肠道菌群：展望未来，审视自身——系统综述和叙述综合分析
Daniel Guimarães de Oliveira,Alexandra Machado,Pedro Castro Lacerda et al.
Daniel Guimarães de Oliveira et al.
Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease shaped by complex interactions involving genetic and environmental factors. Among these, the gut microbiome is emerging as potentially m...
The roles of S100A8/A9 and S100A12 in autoimmune diseases: Mechanisms, biomarkers, and therapeutic potential [0.03%]
S100A8/A9和S100A12在自身免疫性疾病中的作用：机制、生物标志物及治疗潜力
Xiaoqing Wang,Ying Luo,Qiang Zhou et al.
Xiaoqing Wang et al.
The S100 protein family, the largest group of calcium-binding proteins, functions as key molecular regulators both intracellularly and extracellularly. Among these, S100A8/A9 and S100A12 have gained particular attention for their roles in t...
Hedgehog signaling pathway: A research review on a new therapeutic target for rheumatoid arthritis [0.03%]
刺猬信号途径：一个新的治疗靶点在类风湿关节炎中的研究进展综述
Yonglin Yan,Chengxia Sun,Minh Hung Hoang et al.
Yonglin Yan et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint destruction, with existing therapies limited by adverse effects and incomplete efficacy. The Hedgehog signaling pathway, abnormally activated in RA...
Updated systematic literature review and meta-analysis to inform the Italian Society of Rheumatology Recommendations on the treatment of rheumatoid arthritis-associated interstitial lung disease [0.03%]
更新系统文献回顾和荟萃分析以制定意大利风湿病学会关于类风湿关节炎相关间质性肺疾病的治疗建议
A Fassio,M Sebastiani,F Pollastri et al.
A Fassio et al.
Background: rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). Despite recent guideline initiatives, no treatment recommendations spe...
Animal models for connective tissue disease-associated interstitial lung disease: Current status and future directions [0.03%]
结缔组织病相关间质性肺疾病的动物模型：现状与未来方向
Ziyi Tang,Hang Yang,Xiuping Liang et al.
Ziyi Tang et al.
Interstitial lung disease (ILD) significantly contributes to connective tissue disease (CTD) mortality. Although guidelines for managing CTD-associated ILD (CTD-ILD) exist, many patients respond poorly to treatment owing to two key factors:...
Durga Prasanna Misra,Chetan B Mukhtyar,Kunal Chandwar et al.
Durga Prasanna Misra et al.
The fragility of randomized controlled trials (RCTs) of large vessel vasculitis (LVV) - defined as the minimum number of outcome events that would need to change to reverse the trial's conclusions - has not been comprehensively studied. We ...
Artificial intelligence for biopsies and imaging modalities in systemic autoimmune rheumatic diseases: An instructive narrative review [0.03%]
自身免疫性风湿病的活检和影像学的人工智能：一篇指导性的叙述性综述
Konstantinos N Panagiotopoulos,Nikos Tsiknakis,Dimitrios I Zaridis et al.
Konstantinos N Panagiotopoulos et al.
Purpose: To organize the existing literature regarding applications of artificial intelligence (AI) in biopsies and imaging modalities of patients with systemic autoimmune rheumatic diseases (SARDs) and to familiarize rea...
In search of biomarkers for prediction of drug treatment responses in rheumatoid arthritis: Lessons learned and future perspectives [0.03%]
寻找生物标志物以预测类风湿性关节炎药物治疗反应：经验与展望
Athanasia Dara,Nikolaos I Vlachogiannis,George E Fragoulis et al.
Athanasia Dara et al.
Prompt initiation of effective drug treatment is crucial for controlling inflammation and preventing disease progression in rheumatoid arthritis, the most prevalent systemic rheumatic disease. The growing range of drug therapies over the pa...
Anna Wajda,Agnieszka Paradowska-Gorycka,Charlotte Esser
Anna Wajda
Systemic sclerosis (SSc) is a complex and debilitating autoimmune disease marked by fibrosis of the skin and inner organs, alongside chronic inflammation, and vascular abnormalities. SSc pathogenesis involves both genetic and environmental ...
Rapid radiographic progression in rheumatoid arthritis: Definition, prediction and treatment [0.03%]
快速影像学进展型类风湿关节炎：定义、预测与治疗
Bo Lv,Fanshu Li,Fanlei Hu et al.
Bo Lv et al.
Rapid radiographic progression (RRP) in rheumatoid arthritis (RA) is strongly correlated with unfavorable long-term prognostic outcomes. Early identification of RRP is paramount, as prompt intervention and the implementation of intensified ...