Pedro Carneiro,Manuel M Vicente,Maria Isabel Leite et al.
Pedro Carneiro et al.
Regulatory T cells (Tregs) have a key role in the maintenance of immune tolerance and in the prevention of autoimmunity. Recent studies have shown an association between decreased Treg frequency and a deficient suppressive activity with the...
Epigenetics in autoimmune diseases: Unraveling the hidden regulators of immune dysregulation [0.03%]
自身免疫疾病中的表观遗传学：揭示免疫失调的隐藏调节因子
Giacomo Bagni,Edoardo Biancalana,Emanuele Chiara et al.
Giacomo Bagni et al.
Autoimmune diseases result from complex interactions between genetic and environmental factors. Recent advances in epigenetic research shed light on the intricate regulatory mechanisms that contribute to the development and progression of s...
The immune system in Hashimoto's thyroiditis: Updating the current state of knowledge on potential therapies and animal model construction [0.03%]
桥本甲状腺炎中的免疫系统：关于潜在疗法和动物模型构建的最新知识更新
Ruixi Li,Ting He,Zhichao Xing et al.
Ruixi Li et al.
Hashimoto's thyroiditis (HT) is one of the most prevalent endocrine disorders worldwide, and it can occur in people of all ages, including children. HT has a multifactorial pathogenesis and develops after a combination of gene regulation, e...
Beyond circulating B cells: Characteristics and role of tissue-infiltrating B cells in systemic sclerosis [0.03%]
循环B细胞以外：系统性硬化症中组织浸润B细胞的特征及作用
Mathilde Le Maître,Thomas Guerrier,Sébastien Sanges et al.
Mathilde Le Maître et al.
B cells play a key role in the pathophysiology of systemic sclerosis (SSc). While they are less characterized than their circulating counterparts, tissue-infiltrating B cells may have a more direct pathological role in tissues. In this revi...
Cell type-specific regulation of the pentose phoshate pathway during development and metabolic stress-driven autoimmune diseases: Relevance for inflammatory liver, renal, endocrine, cardiovascular and neurobehavioral comorbidites, carcinogenesis, and aging [0.03%]
在发育和代谢压力驱动的自身免疫性疾病中五碳糖磷酸途径的细胞类型特异性调控：对于炎症性肝肾内分泌心血管和神经行为共病，致癌作用和衰老的相关性
Katalin Banki,Andras Perl
Katalin Banki
The pathogenesis of autoimmunity is incompletely understood which limits the development of effective therapies. New compelling evidence indicates that the pentose phosphate pathway (PPP) profoundly regulate lineage development in the immun...
Risk relationship between six autoimmune diseases and malignancies: An umbrella review [0.03%]
六种自身免疫性疾病与恶性肿瘤的风险关系：一项伞状回顾
Ping Yang,Qinguo Liu,Hengheng Zhang et al.
Ping Yang et al.
Background: The bidirectional relationship between autoimmune diseases and malignancy has been widely discussed. And the relationship between autoimmune diseases and the risk of malignancy varies. Here, we categorized and...
The conspiring role of gut microbiota as primer of autoimmune thyroid diseases: A scoping focus [0.03%]
肠道菌群作为自身免疫性甲状腺疾病的始动因子的共谋作用：一个探讨重点
Linda Sessa,Elena Malavolta,Giorgio Sodero et al.
Linda Sessa et al.
The thyroid gland is the body's largest single organ specialized for endocrine hormone production, and still unraveled mechanisms regulate its interaction between the hypothalamic-pituitary-thyroid axis and composition of the gut microbiota...
Framework for implementing treat-to-target in systemic lupus erythematosus routine clinical care: Consensus statements from an international task force [0.03%]
系统性红斑狼疮常规临床护理中实施治疗目标框架的共识声明：国际工作组的任务force
Matteo Piga,Ioannis Parodis,Zahi Touma et al.
Matteo Piga et al.
Implementation of Treat-to-Target (T2T) in routine clinical practice remains low in systemic lupus erythematosus (SLE). Real-world data reveal excessive use of glucocorticoids (GCs) and frequently inadequate disease control. Here, an intern...
Dysregulated circular RNAs in rheumatoid arthritis: Cellular roles and clinical prospects [0.03%]
风湿性关节炎中失调的环状RNA：细胞作用和临床前景
Mengshi Tang,Hongxing Li,Siyuan Chang et al.
Mengshi Tang et al.
Rheumatoid arthritis (RA) is still a healthcare challenge, although current therapeutic strategies have substantially improved its clinical outcomes. The development of novel biomarkers and treatments can increase the likelihood of identifi...