Macrophage polarization regulates the pathogenesis and progression of autoimmune diseases [0.03%]
巨噬细胞极化调节自身免疫疾病的发病和进展
Siwen Wu,Shubi Zhao,Lei Hai et al.
Siwen Wu et al.
Macrophages are integral components of the innate immune system, present in nearly all tissues and organs throughout the body. They exhibit a high degree of plasticity and heterogeneity, participating in immune responses to maintain immune ...
The role of interleukin inhibitors in the treatment of hidradenitis suppurativa; a systematic review of clinical trials [0.03%]
白细胞介素抑制剂在汗腺炎治疗中的作用；临床试验系统性回顾
Nazila Heidari,Amirhossein Heidari,Sara Eghbali et al.
Nazila Heidari et al.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that presents significant treatment challenges. Recent advancements have enhanced our understanding of its pathophysiology, leading to the development of novel therapeuti...
Autophagy in myositis, a dysregulated pathway, and a target for therapy [0.03%]
自身炎症中自噬的紊乱及其作为治疗靶点的作用
A S Kamalanathan,Vikas Agarwal,Laura Talamini et al.
A S Kamalanathan et al.
Corticosteroids and immunosuppressants are the mainstay of therapy for idiopathic inflammatory myopathies (IIMs). However, a significant therapeutic challenge extends beyond mitigating inflammation with these agents to achieving meaningful ...
The entrenchment of NLRP3 inflammasomes in autoimmune disease-related inflammation [0.03%]
NLRP3炎症小体在自身免疫性疾病相关炎症中根除的作用
Valeria Carnazzo,Donato Rigante,Giuliana Restante et al.
Valeria Carnazzo et al.
Autoinflammation and autoimmunity are almost "opposite" phenomena characterized by chronic activation of the immune system, 'innate' in the first and 'adaptive' in the second, leading to inflammation of several tissues with specific protean...
The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases [0.03%]
CRISPR-Cas9和CRISPR干扰技术在自身免疫病治疗中的作用研究进展
Zahra Khademi,Negar Mottaghi-Dastjerdi,Hamed Morad et al.
Zahra Khademi et al.
Autoimmune disorders can be described as inappropriate immune responses directed against self-antigens, which account for substantial healthcare concerns around the world. Immunosuppression or immune modulation are the main therapeutic moda...
Cochlear T cells and their role in health and disease: A systematic review [0.03%]
耳蜗T细胞及其在健康和疾病中的作用：系统性综述
Evi De Backer,Dorien Verdoodt,Peter Ponsaerts et al.
Evi De Backer et al.
Background: The role of T cells in health and disease has already been studied extensively in many organs, yet their activity in the cochlea and involvement in hearing loss remains less explored. This review aims to summa...
Molecular/antigenic mimicry and immunological cross-reactivity explains SARS-CoV-2-induced autoimmunity [0.03%]
分子/抗原模拟和免疫交叉反应可解释SARS-CoV-2诱导的自身免疫反应
Yekbun Adiguzel,Dimitros P Bogdanos,Yehuda Shoenfeld
Yekbun Adiguzel
COVID-19 pandemic is over, but its effects on chronic illnesses remain a challenging issue. Understanding the influence of SARS-COV-2-mediated autoimmunity and overt autoimmune disease is of paramount importance, as it can provide a critica...
The impact of pregnancy on future health in Rheumatoid Arthritis: A systematic review of the literature [0.03%]
妊娠对类风湿性关节炎患者未来健康影响的文献系统回顾
Bethan Goulden,George Woodward,Sophie Leiner et al.
Bethan Goulden et al.
Objectives: To assess whether obstetric history predicts future rheumatoid arthritis (RA) diagnosis, severity, and/or maternal health beyond the immediate postpartum period. ...
Emerging roles of mechanically activated ion channels in autoimmune disease [0.03%]
机械激活离子通道在自身免疫疾病中的新角色
Zhiru Zeng,Engeng Chen,Jing Xue
Zhiru Zeng
Mechanically activated (MA) ion channels have rapidly gained prominence as vital conduits bridging aberrant mechanical cues in tissues with the dysregulated immune responses at the core of autoimmune diseases. Once regarded as peripheral pl...
The burden of extracutaneous manifestations in juvenile localized scleroderma: A literature review [0.03%]
局灶性硬皮病外皮肤表现的负担：文献综述
Ilaria Liguoro,Gabriele Simonini,Giorgia Martini
Ilaria Liguoro
Objectives: Juvenile Localized Scleroderma (JLS) is an autoimmune disease leading to fibrosis of skin and subcutaneous tissues affecting children, that is characterized by extracutaneous manifestations (ECM) in about 20 %...