Risk of infection for different B-cell targettaing agents in treating systemic lupus erythematosus: A systematic review and network meta-analysis [0.03%]
系统性红斑狼疮抗B细胞药物感染风险的系统评价和网络Meta分析
Zhibin Yu,Yuxiang Lin
Zhibin Yu
Objectives: This study aimed to assess the risk of infections in the treatment of systemic lupus erythematosus (SLE) with various B-cell targeting agents. ...
The regulatory roles of Beta-2 glycoprotein I (β2GPI) in thrombosis and hemostasis and abnormal disease conditions developed by autoantibodies against β2GPI [0.03%]
β2GP1在血栓与止血及抗β2GP1自身抗体相关疾病中的调控作用
Ruiying Wang,Xian Wen Tan,Chunyan Yu et al.
Ruiying Wang et al.
Beta-2 glycoprotein I (β2GPI) as a core target antigen of antiphospholipid antibodies (aPLs), is a multifunctional plasma protein with phospholipid-binding properties. Under physiological conditions, β2GPI not only binds to negatively cha...
The Trm-Treg Axis as a tissue-encoded immune checkpoint in chronic inflammation and autoimmunity [0.03%]
慢性炎症和自身免疫中的组织编码免疫检查点Trm-Treg轴
Liang Li,Yumin Xia,Yale Liu
Liang Li
Tissue-resident memory T (Trm) cells, once heralded as gatekeepers of localized immune protection, have emerged as central players in the pathogenesis of chronic inflammation and autoimmunity at epithelial barriers. At the heart of this imm...
The metabolic landscape of connective tissue diseases: Applications and discoveries in metabolomics research [0.03%]
连接组织病的代谢图谱：代谢组学研究中的应用和发现
Yinlan Wu,Daihua Deng,Yanhong Li et al.
Yinlan Wu et al.
Metabolomics has significantly advanced our understanding of connective tissue diseases (CTDs) in recent years by revealing the complex metabolic alterations that underlie these autoimmune disorders. This comprehensive review synthesizes cu...
FcγRIIa in autoimmunity: Unraveling pathogenic mechanisms and therapeutic opportunities [0.03%]
FcγRIIa在自身免疫中的作用：揭示致病机制和治疗机会
Bo Zhu,Xinhua Cao,Xue Wang et al.
Bo Zhu et al.
Autoantibodies, hallmark mediators of autoimmune diseases, drive pathogenesis through Fc receptors (FcRs) engagement. Among human FcRs, FcγRIIa is the most abundantly expressed subtype and plays a pivotal role in regulating both innate and...
Discrepancy between international guidelines and global laboratory practices in autoantibody testing for autoimmune hepatitis [0.03%]
自身免疫性肝炎自身抗体检测的国际指南与全球实验室实践之间的差异
Nicola Bizzaro,Dimitrios Bogdanos
Nicola Bizzaro
Therapeutic approaches in adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of current evidence [0.03%]
成人髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)的治疗策略：现有证据综述
Jakob Stögbauer,Victoria Schegerer,Clemens Klein et al.
Jakob Stögbauer et al.
Recent years have seen a considerable increase in knowledge pertaining to Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Nevertheless, a noteworthy degree of uncertainty remains within the neurological community, p...
Targeting age-related cell-free DNA for prevention, early diagnosis and treatment of rheumatoid arthritis [0.03%]
针对年龄相关的细胞游离DNA以预防、早期诊断和治疗类风湿性关节炎
Ning Ma,Yulin Xu,Dingqi Zhang et al.
Ning Ma et al.
Cell-free DNA (cf-DNA) refers to extracellular DNA fragments released during cell death, which have been observed to accumulate with advancing age. Elevated cf-DNA concentrations have been detected in the plasma and disease-affected tissues...
Autoantibody internalization in myositis skeletal muscle: Emerging evidence, mechanistic insights, and therapeutic relevance [0.03%]
多发性肌炎骨骼肌中自身抗体的内吞作用：新兴证据、机制见解和治疗相关性
Raphael A Kirou,Iago Pinal-Fernandez,Andrew L Mammen
Raphael A Kirou
The inflammatory myopathies-including dermatomyositis, immune-mediated necrotizing myopathy, anti-synthetase syndrome, and overlap myositis-are systemic autoimmune diseases characterized by myositis-specific and myositis-associated autoanti...
Extracellular vesicles in autoimmune diseases: Mechanistic underpinnings and precision medicine applications [0.03%]
自身免疫性疾病中胞外囊泡的作用及精准医疗应用：机制研究
Wenhui Mo,Yujie Zhang,Yu Zeng et al.
Wenhui Mo et al.
Autoimmune diseases constitute a collection of complex disorders characterized by abnormal immune responses directed against self-tissues. The pathogenesis of these diseases is strongly linked to the interaction of genetic predispositions a...