In utero exposure to Azathioprine in autoimmune disease. Where do we stand? [0.03%]
妊娠期接触硫唑嘌呤在自身免疫性疾病中有哪些作用？目前进展如何？
Cristina Belizna,Pier Luigi Meroni,Yehuda Shoenfeld et al.
Cristina Belizna et al.
Azathioprine (AZA), an oral immunosuppressant, is safe during pregnancy. Some reports suggested different impairments in the offspring of mothers with autoimmune diseases (AI) exposed in utero to AZA. These observations are available from r...
Yanli Tong,Tony Marion,Georg Schett et al.
Yanli Tong et al.
As a gigantic community in the human body, the microbiota exerts pleiotropic roles in human health and disease ranging from digestion and absorption of nutrients from food, defense against infection of pathogens, to regulation of immune sys...
Rheumatoid arthritis in the elderly: Characteristics and treatment considerations [0.03%]
老年人类风湿关节炎的临床特点及治疗注意事项
Lina Serhal,May N Lwin,Christopher Holroyd et al.
Lina Serhal et al.
The elderly rheumatoid arthritis (RA) population consists of both elderly-onset RA that manifests after the age of 60 and individuals diagnosed with RA early in life who age naturally to become members of this group. The elderly RA populati...
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review [0.03%]
免疫失调、多内分泌病、肠病性X连锁综合征(IPEX 综合征)的系统评价
Jae Hyon Park,Keum Hwa Lee,Bokyoung Jeon et al.
Jae Hyon Park et al.
Background: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder characterized by early onset fatal multi-system autoimmunity due to loss-of-function mutations in the gen...
Orna Geyer,Yoram Levo
Orna Geyer
Glaucoma is characterized by retinal ganglion cell (RGC) neurodegeneration. Elevated intraocular pressure (IOP) is a major risk factor however, mechanisms independent of IOP play a role in RGC pathology. Both antibodies and CD4 T-cells as w...
Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014 [0.03%]
2001年至2014年自身免疫性系统性疾病全因死亡率的全球趋势
Marc Scherlinger,Philippe Mertz,Flora Sagez et al.
Marc Scherlinger et al.
Aim: To describe changes in the 2001-2014 mortality of 6 autoimmune systemic diseases (AISDs), namely Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathies (IIM), Sjögren's Synd...
Autoimmune thyroid disorders and rheumatoid arthritis: A bidirectional interplay [0.03%]
自身免疫性甲状腺疾病和类风湿关节炎：双向相互作用
Paola Conigliaro,Arianna D&#x;Antonio,Sara Pinto et al.
Paola Conigliaro et al.
Rheumatoid arthritis (RA) and autoimmune thyroid disease (AITD) can occur in the same patient in the autoimmune polyglandular syndrome 2. The association of the two conditions has been recognized long-time ago and the prevalence of AITD in ...
Melody P Chung,Carrie Richardson,David Kirakossian et al.
Melody P Chung et al.
Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by muscle weakness and cutaneous manifestations in adults and children. Calcinosis, a complication of DM, is the abnormal deposition of insoluble calcium salts in...
Maaike Biewenga,Arantza Farina Sarasqueta,Maarten E Tushuizen et al.
Maaike Biewenga et al.
Introduction: The complement system, an essential part of the innate immune system, is involved in various autoimmune diseases. Activation of the complement system by autoantibodies results in immune activation and tissue...
Comprehensive meta-analysis reveals an association of the HLA-DRB1*1602 allele with autoimmune diseases mediated predominantly by autoantibodies [0.03%]
全面的荟萃分析揭示HLA-DRB1*1602等位基因与自身抗体介导为主的自身免疫疾病相关联
Yan Chen,Shasha Li,Renliang Huang et al.
Yan Chen et al.
The human leukocytes antigen (HLA)-DRB1*16:02 allele has been suggested to be associated with many autoimmune diseases. However, a validation of the results of the different studies by a comprehensive analysis of the corresponding meta data...