Regulatory mechanisms and targeted therapeutic strategies of glycolytic metabolism in rheumatoid arthritis [0.03%]
糖酵解代谢在类风湿性关节炎中的调控机制与靶向治疗策略研究
Miao Wang,Ke Wan,Han Shu et al.
Miao Wang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease where glycolytic metabolism plays a crucial role in its pathogenesis. This paper delves into the characteristics, key roles, and potential therapeutic applications of glycolytic meta...
Treatment of pediatric chronic nonbacterial osteomyelitis - a systematic review [0.03%]
儿童慢性非细菌性骨髓炎的治疗-系统综述
Sarah Turner,Eve Roberts,Natalie Hall et al.
Sarah Turner et al.
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease most commonly affecting children and young people. CNO can cause bone pain, hyperostosis and fractures, thereby significantly impacting on patients' wellbeing. The...
Heavy and trace metals toxicity implications in the breakdown of cellular homeostasis: A risk factor for rheumatoid arthritis pathogenesis [0.03%]
重金属毒性对细胞稳态破坏的影响：类风湿关节炎发病的风险因素
Nemat Ali,Ali M Alaseem,Md Meraj Ansari et al.
Nemat Ali et al.
Occupational and environmental exposure to heavy and trace metals is increasingly implicated in cellular dysfunction underlying the pathogenesis of rheumatoid arthritis (RA). While trace metals such as selenium (Se), zinc (Zn), and copper (...
Jelle Miedema,Hilario Nunes,Virgil A S H Dalm et al.
Jelle Miedema et al.
Sarcoidosis is an inflammatory granulomatous disease that affects people worldwide and can involve virtually any organ but most commonly the lungs and thoracic lymph nodes. The cause of sarcoidosis remains unknown, but occupational and envi...
Causation-based SLE diagnostic criteria should replace advance-repressing SLE classification criteria [0.03%]
因果关系-Based SLE诊断标准应取代抑制进展的SLE分类标准
Ole Petter Rekvig,George C Tsokos
Ole Petter Rekvig
Systemic lupus erythematosus (SLE) presents with diverse clinical manifestations originating from multiple contributing factors employing a complex array of pathogenetic pathways. Understanding the origin of the disease is stifled by the as...
Idiopathic pericarditis in 2025: Advances in diagnosis and therapeutic strategies [0.03%]
特发性心包炎的诊断和治疗策略进展（2025）
Martin Michaud,Yvan Jamilloux,Clément Delmas et al.
Martin Michaud et al.
Idiopathic acute pericarditis is the most frequent form of acute pericarditis in Western countries. Although the short-term course of an uncomplicated first episode is often benign, a substantial proportion of patients progress to complicat...
Recent advances in the mechanisms and treatment of cuproptosis in autoimmune diseases [0.03%]
铜死亡在自身免疫病发病机制及治疗中的研究进展
Yan Liu,Xiyuan Bao,Xin Dai et al.
Yan Liu et al.
Autoimmune diseases, characterized by the immune system's erroneous attack on the body's own tissues, are highly challenging to treat. Recently discovered cuproptosis, triggered by excess copper ions, leads to the abnormal accumulation of a...
LAG-3 in (auto)immunity and cancer - Emphasising its role in antigen presenting cells [0.03%]
LAG-3在(auto)免疫和癌症中的作用——强调其在抗原呈递细胞中的作用
Aleksandra Wiśniewska,Elżbieta Sarnowska,Katarzyna Kozak et al.
Aleksandra Wiśniewska et al.
The growing popularity of immunotherapy shows a promising future for cancer treatment. However, a significant need to develop new therapeutics that could be successfully used in therapy still remains, especially in "immune-cold" tumors that...
Metabolic traits of T cells and the implications in autoimmune diseases [0.03%]
T细胞的代谢特征及其在自身免疫病中的意义
Yi Zhou,Yuqi Zhou,Qing Zhu et al.
Yi Zhou et al.
The metabolic activities of T cells play a pivotal role in regulating their activation, differentiation, and effector functions. In recent years, it has emerged as a key focus of research in the maintenance of immune homeostasis and the mod...
Aidan K Strother,Robert M Anderton,Naveen Kalavar et al.
Aidan K Strother et al.
Objective: To systematically review and synthesize the histological findings of gastrointestinal (GI) tissue in patients with systemic sclerosis (SSc), aiming to clarify the role of fibrosis and other pathological process...