USP53 promotes NOTCH2-induced neuroinflammation in Alzheimer's disease [0.03%]
USP53促进NOTCH2诱导的阿尔茨海默病神经炎症反应
Dandan He,Huajian Zhao,Yong Zhu et al.
Dandan He et al.
Purpose: This study aimed to investigate the role of USP53 and its associated signaling pathway associated with USP53 in Alzheimer's disease (AD). Methods...
Alcohol disrupts neural differentiation through endoplasmic reticulum stress and PERK pathway activation [0.03%]
酒精通过内质网压力和PERK途径活化扰乱神经分化
Zuohui Zhang,Wen Wen,Hong Lin et al.
Zuohui Zhang et al.
Prenatal alcohol exposure (PAE) can lead to fetal alcohol spectrum disorder (FASD), a condition marked by developmental brain defects that result in neurobehavioral and cognitive impairments. However, the underlying molecular mechanisms rem...
BLF stimulates neuronal differentiation via activation of p35/CDK5 signaling and AMPK-mediated mitochondrial regulation [0.03%]
BLF通过激活p35/CDK5信号通路和AMPK介导的线粒体调控促进神经元分化
Abdulkadir Cidem,Muhammet Oner,Gary Ro-Lin Chang et al.
Abdulkadir Cidem et al.
Lactoferrin (LF) is a multifunctional glycoprotein with established roles in non-neuronal cell growth and differentiation and has underexplored potential in neurodevelopment. Here, we investigated bovine lactoferrin (bLF) as a neurotrophic ...
Butein suppresses depolarization-evoked glutamate release by modulating P/Q-type Ca2+ channels and protein kinase C pathway in rat cortical synaptosomes [0.03%]
染料木黄酮通过调节P/Q型Ca2+通道和蛋白激酶C通路抑制大鼠皮层突触体中去极化引起的谷氨酸释放
Ming-Shang Pai,Mao-Hsiang Hsiao,Ming-Yi Lee et al.
Ming-Shang Pai et al.
This study examined the effects of butein, a natural chalcone, on glutamate release from rat cortical synaptosomes and elucidated the underlying mechanisms. Using 4-aminopyridine (4-AP) to evoke glutamate releases, we found that butein inhi...
GPR55 deficiency exacerbates cognitive impairments and Alzheimer's disease-like pathology in mice [0.03%]
GPR55缺乏加剧小鼠认知障碍和阿尔茨海默病样病变
Bing Fan,YuSheng Liang,TianTian Zhi et al.
Bing Fan et al.
Background: Alzheimer's disease (AD) is the most common type of dementia, characterized by progressive cognitive decline and neuronal damage. Although studies have indicated a link between G-protein coupled receptor 55 (G...
Assessing the critical role of ceramide in the pathogenesis of Alzheimer's disease and its clinical significance [0.03%]
脑苷酯在阿尔茨海默病发病机制中的关键作用及其临床意义评估
Yi-Wen Huang,Hua-Chen Chan,Jing-Yi Khoo et al.
Yi-Wen Huang et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) deposition, tau hyperphosphorylation, and synaptic loss. Emerging evidence indicates that apolipoprotein E (APOE) polymorphism and dysreg...
Astaxanthin inhibits the aggregation and cytotoxicity of tau4RDΔK280 via possible interaction with the aggregation-prone segments [0.03%]
虾青素通过可能与Tau聚集倾向片段的相互作用抑制tau4RDΔK280蛋白聚合和细胞毒性
Huahua Shi,Yan Zhao
Huahua Shi
Tauopathies are a group of neurodegenerative disorders characterized by the presence of abnormal aggregates of microtubule associated protein tau in the brain. In the most common tauopathy, Alzheimer's disease (AD), the aggregation of tau i...
Tricyclic antidepressant amitriptyline potentiates brain-derived neurotrophic factor expression mediated by PKC delta-NF-kappa B signaling in primary cultured astrocytes with connexin43-knockdown [0.03%]
三环类抗抑郁药阿米替林通过PKCdelta-NFkB信号增强缝隙连接蛋白43敲低的原代星形胶质细胞介导的脑源性神经营养因子表达
Nozomi Tokunaga,Rikako Fujimoto,Yoki Nakamura et al.
Nozomi Tokunaga et al.
Depression is a major mental illness, and its underlying mechanisms remain unclear. Emerging evidence suggests that astrocytes, which play a crucial role in brain function, may be involved in the pathophysiology of depression. We previously...
SPI1 suppresses YAP phosphorylation in vascular endothelial cells to prevent intracranial aneurysm progression [0.03%]
SPI1通过抑制血管内皮细胞中YAP的磷酸化来预防颅内动脉瘤的发展
Yikui Liu,Danyi Zheng,Lanlan Zhao et al.
Yikui Liu et al.
This study aims to elucidate the mechanism by which YAP mediates the activity of vascular endothelial cells (ECs) in the biological process of intracranial aneurysms (IAs) and to provide a novel target for noninvasive IAs treatment. Single-...
Investigating the role of GABAergic interneurons in the antidepressant-like mechanism of agomelatine [0.03%]
阿戈美拉汀抗抑郁样作用的神经机制研究
Suhong Ye,Qiaolu Xu,Nashwa Amin et al.
Suhong Ye et al.
Depression is a prevalent and debilitating mental disorder with substantial impacts on global health and socioeconomic costs. Despite various antidepressants targeting monoaminergic neurotransmission, a significant proportion of patients fa...