Short-term infusion of GDF11 after SCI attenuates pericytes loss and BSCB damage to promote recovery of spinal cord function [0.03%]
SCI后短期输注GDF11减轻周细胞丢失和BSCB损伤以促进脊髓功能恢复
Honghao Shen,Jiangtao Liu,Minghao Du et al.
Honghao Shen et al.
To investigate the role of GDF11 in acute neural trauma, this study focused on the effects of GDF11 on pericytes and the blood-spinal cord barrier (BSCB) following spinal cord injury (SCI). We established a mouse SCI model and administered ...
ERK-Dependent Astrocytic PAI-1 Induction by Influenza A Virus Disrupts the Neurochemical Balance of the PAI-1/tPA Axis [0.03%]
流感病毒诱导星形胶质细胞PAI-1的产生及其对PAI-1/tPA轴神经化学平衡的影响
Eun-Sook Park,Bo-Bae Park,Ryeong-Eun Kim et al.
Eun-Sook Park et al.
Background: Influenza A virus (IAV), although primarily a respiratory pathogen, is increasingly recognized to affect central nervous system (CNS) function. Astrocytes are key regulators of neurochemical homeostasis and ne...
Involvement of α7 nicotinic acetylcholine receptor-signaling in social behavior impairments in the stressed mice [0.03%]
应激小鼠社会行为损伤与α7烟碱型乙酰胆碱受体信号系统的关系研究
Mizuki Uchida,Masaki Kano,Norio Ozaki et al.
Mizuki Uchida et al.
Smoking is considered a form of self-medication for psychosis, including nicotine (NIC) dependence, through stimulation of the nicotinic acetylcholine receptors (nAChRs) in the central nervous system of patients with psychiatric disorders. ...
Blood extracellular vesicles contribute to the exercise-mediated suppression of brain Aβ pathology in the AppNL-G-F knockin mouse model of Alzheimer's disease [0.03%]
小鼠血液外泌体对阿尔茨海默病脑内淀粉样蛋白病理的调节作用研究
Akiko Takeda,Toshihide Takeuchi,Eiko N Minakawa et al.
Akiko Takeda et al.
Epidemiological, clinical, and experimental evidence suggest that physical exercise suppresses the deposition of amyloid β (Aβ) plaques in the brain and reduces the risk of Alzheimer's disease (AD). However, how exercise provides such ben...
Sanguinarine alleviates pendimethalin-induced neurotoxicity via regulating microglial and neuroinflammatory pathways: An interplay of oxidative stress, apoptosis and microglial polarization [0.03%]
血根碱通过调节小胶质细胞和神经炎症途径缓解pendimethalin诱导的神经毒性：氧化应激、凋亡和小胶质细胞极化之间的相互作用
Kang Zhang,Kiran Amir,Arifa Mehreen et al.
Kang Zhang et al.
Pendimethalin (PMN) is a potent agrochemical that has shown severe neural alterations. Sanguinarine (SAN) is a naturally derived alkaloid that exhibits a wide range of biological properties. The current research was conducted to explore the...
Swertisin improves Alzheimer's disease-like pathology in 5XFAD male mice through regulation in plasmin activity [0.03%]
sweritin通过调节纤溶酶活性改善5XFAD雄性小鼠的类似阿尔茨海默病的病理变化
Somin Moon,Huiyoung Kwon,Eunbi Cho et al.
Somin Moon et al.
Abnormal accumulation of amyloid β (Aβ), which may result from excessive production or impaired clearance, is one of the pathomechanisms of Alzheimer's disease (AD). Plasmin is one of the important proteases involved in the Aβ clearance ...
Functional Magnetic Resonance Imaging of Frontotemporal Dual-Site Repetitive Transcranial Magnetic Stimulation in Subjective Tinnitus [0.03%]
主观性耳鸣双侧重复经颅磁刺激的前额叶和颞叶功能磁共振成像研究
Feng Wen,Xi Yang,Guoqing Jing et al.
Feng Wen et al.
Objective: This study investigated the neurofunctional effects of frontotemporal dual-site repetitive transcranial magnetic stimulation (rTMS) in patients with subjective tinnitus (ST). ...
Receptor Tyrosine Kinases in Alzheimer's Disease: Mechanistic Insights and Therapeutic Implications [0.03%]
阿尔茨海默病中的受体酪氨酸激酶：机制见解与治疗意义
Pengyu Zhao,Zelin Cao,Wioletta Rozpędek-Kamińska
Pengyu Zhao
Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis remains incompletely understood. It is considered one of the most costly, fatal, and socially burdensome diseases of the twenty-first century. Previous stud...
24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: a novel link between brain cholesterol homeostasis and androgen metabolism [0.03%]
24-羟基胆固醇通过抑制类固醇5α还原酶催化的转化来抑制人体胶质母细胞瘤细胞系：中枢神经系统中胆固醇稳态与雄激素代谢之间的新联系
Kjell Wikvall,Frida Olsson,Erik Wåhlén et al.
Kjell Wikvall et al.
Glioblastoma is the most aggressive primary brain tumor in adults. Androgens are reported to influence the development of glioblastoma. Dihydrotestosterone (DHT) is formed from testosterone by action of the enzyme steroid 5α-reductase and ...
Redox-sensitive high mobility group box 1 (HMGB1) protein is a multipotent regulator in the pathogenesis of Alzheimer's disease [0.03%]
红氧敏感的高迁移率族蛋白箱1（HMGB1）蛋白是阿尔茨海默病发病机制中多潜能调节因子
Antero Salminen
Antero Salminen
The primary cause of Alzheimer's disease (AD) is still unknown although genetic studies have identified several risk genes and significant alterations in the chromatin landscape. These genetic changes are associated with neuroinflammation a...