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ERK-Dependent Astrocytic PAI-1 Induction by Influenza A Virus Disrupts the Neurochemical Balance of the PAI-1/tPA Axis

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Background: Influenza A virus (IAV), although primarily a respiratory pathogen, is increasingly recognized to affect central nervous system (CNS) function. Astrocytes are key regulators of neurochemical homeostasis and neuroinfla... ...