Overexpression of Thioredoxin-1 alleviates morphine-induced neuroinflammation in BV-2 cells and the ventral tegmental area of mice [0.03%]
过表达硫氧还蛋白-1可缓解吗啡致小胶质细胞BV-2炎症及对小鼠腹侧被盖区的毒性作用
Zhipeng Lu,Yang Long,Xiang Li et al.
Zhipeng Lu et al.
The clinical utility of morphine is limited by the development of tolerance and addiction. These processes are linked to neuroinflammation involved microglial responses. Thioredoxin-1 (Trx-1) is a crucial endogenous antioxidant with neuropr...
IL-33/ST2 deficiency induces depression-like behaviors through neuroinflammation in the medial prefrontal cortex and hippocampus [0.03%]
髓质前额叶皮层和海马体神经炎症介导的IL-33/ST2缺乏引起的类似抑郁行为
Haoyu Wang,Siyu Yang,Jiapei Dai et al.
Haoyu Wang et al.
Depression remains a leading cause of global disability, yet its precise neurobiological underpinnings are incompletely understood. While inflammatory cytokines have been implicated in depressive pathology, the specific role of Interleukin-...
Mitofusin 2 in Central Nervous System Disorders: Roles in Mitochondrial Dynamics and Therapeutic Implications [0.03%]
中枢神经系统疾病中的线粒体融合蛋白2：在线粒体动力学和治疗作用中的功能
Li Tang,Jiehao Huang,Rui Xia et al.
Li Tang et al.
Mitochondrial dynamics have been increasingly recognized as a central determinant in the pathogenesis of central nervous system (CNS) disorders. Mitofusin 2 (MFN2), a critical mitochondrial fusion protein, preserves mitochondrial network in...
Therapeutic potential of biased μ-opioid receptor agonists for delaying opioid tolerance in chronic pain management [0.03%]
偏向性μ型阿片受体激动剂延缓慢性疼痛管理中阿片耐受性的治疗潜力
Xiaorong Liu,Qingbiao Song,Shishan Wang et al.
Xiaorong Liu et al.
Opioid tolerance presents a significant challenge in the treatment of chronic pain, leading to reduced responsiveness following prolonged activation of the μ-opioid receptor (MOR). This necessitates escalating doses, thereby increasing the...
C3 and C5 complement cascade activation in brain injury and disease: Molecular mechanisms, pathological roles, and therapeutic implications [0.03%]
补体C3和C5级联在脑损伤和疾病中的活化：分子机制、病理作用及治疗意义
Geoffrey E Woodard
Geoffrey E Woodard
The complement system represents a crucial component of innate immunity with increasingly recognized roles in central nervous system pathology and homeostasis. Complement components C3 and C5 serve as central molecular hubs in the complemen...
Inhibition of S100A9 Mitigates Aging-Related Mitochondrial Dysfunction and Neurodegeneration in Parkinson's Disease [0.03%]
抑制S100A9缓解帕金森病中与衰老相关的线粒体功能障碍和神经退行性病变
Lu-Lu Tan,Xiao-Yu Ma,Yi-Meng Xia et al.
Lu-Lu Tan et al.
Aging is the most important risk factor for Parkinson's disease (PD). S100A9, a calcium-binding protein, is closely related to a variety of aging-related diseases, but its role in the pathogenesis of PD is still unclear. This study aims to ...
Disrupting PQBP1-eEF2 protein-protein interaction: From synaptic translation to immunity and cancer [0.03%]
PQBP1-eEF2蛋白质-蛋白质相互作用的干扰：从突触翻译到免疫和癌症
Emadeldin M Kamel,Sally Mostafa Khadrawy,Mohamed A M Ali et al.
Emadeldin M Kamel et al.
Polyglutamine-binding protein 1 (PQBP1) has emerged as a multifaceted regulator of gene expression, acting not only in the nucleus to influence transcription and splicing but also in the cytoplasm to control protein synthesis. A recent disc...
Inhibition of ESCRT-III activates alternative pathways for protein degradation and secretion [0.03%]
抑制ESCRT-III可激活蛋白质降解和分泌的替代途径
Masaru Fujiwara,Ryohei Sakai,Masayuki Takahashi et al.
Masaru Fujiwara et al.
Mutations in components of the endosomal sorting complex required for transport (ESCRT)-III, such as CHMP2B and VPS4A/B, are known to cause neurological disorders, including frontotemporal lobar degeneration (FTLD) and developmental encepha...
AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model [0.03%]
通过破坏肠道菌群诱导的抑郁症小鼠模型中AICAR改善抑郁样行为与海马AMPK激活及神经发生和神经炎症调节有关
Kohei Takahashi,Kazuhiro Kurokawa,Ranmaru Kawaguchi et al.
Kohei Takahashi et al.
Gut microbiota alterations are associated with the onset of depression; however, the underlying mechanisms remain unclear. Activation of hippocampal AMP-activated protein kinase (AMPK) in ulcerative colitis mice with disrupted gut microbiot...
GABAergic neuronal ontogeny in the central nervous system of the viviparous teleost Poecilia sphenops [0.03%]
活胎鳉鱼中枢神经系统中GABA能神经元的发育起源研究
Achyutham Hotha,C B Ganesh
Achyutham Hotha
The neurotransmitter gamma-aminobutyric acid (GABA) plays essential roles in vertebrate neurodevelopment and neuroendocrine regulation. However, the post-embryonic ontogeny of the GABAergic system remains relatively poorly characterized, pa...