The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms [0.03%]
行为和神经化学特征的果蝇dysbindin突变体会支持五羟色胺对精神分裂症的作用
Sergio Hidalgo,Christian Castro,Rafaella V Zárate et al.
Sergio Hidalgo et al.
Mutations in the dystrobrevin binding protein 1 (DTNBP1) gene that encodes for the dysbindin-1 protein, are associated with a higher risk for schizophrenia. Interestingly, individuals carrying high-risk alleles in this gene have been associ...
Stimulation of toll-like receptor 4 downregulates the expression of α7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia [0.03%]
TLR4刺激通过组蛋白去乙酰化酶下调小胶质细胞中α7烟碱型乙酰胆碱受体的表达
Yoki Nakamura,Sayuri Kimura,Naoki Takada et al.
Yoki Nakamura et al.
Microglia have both protective and degenerative roles in the central nervous system. The α7 nicotinic acetylcholine receptor (nAChR) is crucial in the regulation of the neuroprotective role in microglia. Recent studies have demonstrated de...
Tetradecyl 2,3-dihydroxybenzoate alleviates oligodendrocyte damage following chronic cerebral hypoperfusion through IGF-1 receptor [0.03%]
四十四烷基对羟基苯甲酸酯通过IGF-1受体缓解慢性脑低灌注引起的少突胶质细胞损伤
Mahmoud I Youssef,Yiting Zhou,Ibrahim H Eissa et al.
Mahmoud I Youssef et al.
Currently, there is no effective therapy for chronic cerebral hypoperfusion-induced subcortical ischemic vascular dementia (SIVD), which displays cognitive deficits and progressive white matter damage. Tetradecyl 2,3-dihydroxybenzoate (ABG-...
Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine [0.03%]
慢性轻度不可预测应激模型中抑郁相关的神经元和星形胶质细胞代谢功能障碍：用Lanicemine逆转行为及代谢异常
Pravin Kumar Mishra,Madhavi Adusumilli,Pallavi Deolal et al.
Pravin Kumar Mishra et al.
Major depressive disorder is the leading cause of disability and suicidality worldwide. Here, we evaluated neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three w...
Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway [0.03%]
κ型阿片受体通过β-阻滞素激活和Akt介导的信号通路使脑室内吞藏作用在氧葡萄糖剥夺中发挥保护作用
Jihong Xu,Fang Chen,Shuyan Wang et al.
Jihong Xu et al.
Hypoxia induces reversible κ-opioid receptor (KOR) internalization similar to the internalization that is induced by KOR agonists. In the current study, we demonstrate that this KOR internalization is a protective mechanism via the β-arre...
Neurobehavioral changes arising from early life dopamine signaling perturbations [0.03%]
生命早期多巴胺信号受干扰引起的行为和神经变化
Lorena B Areal,Randy D Blakely
Lorena B Areal
Dopamine (DA) signaling is critical to the modulation of multiple brain functions including locomotion, reinforcement, attention and cognition. The literature provides strong evidence that altered DA availability and actions can impact norm...
Nonlinear and mixed inhibitory effect of matrine on the cytotoxicity of oligomeric amyloid-β protein [0.03%]
番木鳖碱对寡聚型淀粉样蛋白β诱导细胞毒性作用的非线性及混合抑制效应研究
Bing Yang,Hongli Li,Tianyu Zhang et al.
Bing Yang et al.
The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimer's disease (AD). In this study, we found that matrine (Mat) could maintain or even enh...
Deficits in the vesicular acetylcholine transporter alter lifespan and behavior in adult Drosophila melanogaster [0.03%]
神经递质乙酰胆碱的运输缺陷通过改变果蝇的行为和寿命而导致其早衰
Daniel White,Raquel P de Sousa Abreu,Andrew Blake et al.
Daniel White et al.
The neurotransmitter acetylcholine (ACh) is involved in critical organismal functions that include locomotion and cognition. Importantly, alterations in the cholinergic system are a key underlying factor in cognitive defects associated with...
Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice [0.03%]
胰岛素信号激酶、GLUT3、磷酸化BADser155和硝基酪氨酸在不同低血糖模型小鼠脑中的适应性表达研究
Vigneshwaran Pitchaimani,Somasundaram Arumugam,Rajarajan Amirthalingam Thandavarayan et al.
Vigneshwaran Pitchaimani et al.
Aim and objective: Insulin-induced moderate or severe hypoglycemia (MH or SH) impairs cognition and SH causes neuronal death. On the contrary, alternate day fasting (ADF) protects the brain during excitotoxic stress and i...
Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats [0.03%]
成年大鼠海马腹侧亚脑回损毁后，氯胺酮诱导的核心伏隔核多巴胺信号增强
Hana Saoud,Duco De Beus,Séverine Eybrard et al.
Hana Saoud et al.
For almost two decades schizophrenia has been considered to be a functional disconnection disorder. This functional disconnectivity between several brain regions could have a neurodevelopmental origin. Various approaches suggest the ventral...