Perinatal exposure to alcohol reduces the expression of complexins I and II [0.03%]
孕期接触酒精会降低复合素I和II的表达
Mathias Zink,Gülsemin Araç,Stefanie Th Frank et al.
Mathias Zink et al.
Perinatal exposure to alcohol (PEA) induces general developmental and specific neuropsychiatric disturbances. Ethanol affects amino acid neurotransmission and synaptic plasticity. We were interested in the transcriptional effects of ethanol...
Joseph Yanai,Adi Pinkas,Frederic J Seidler et al.
Joseph Yanai et al.
Nerve gas organophosphates like sarin are likely to be used in urban terrorism, leading to widespread exposures of pregnant women and young children. Here, we established a model for sarin neurobehavioral teratogenicity in the developing ch...
White matter integrity in adolescents with histories of marijuana use and binge drinking [0.03%]
有大麻使用和酗酒史的青少年的大脑白质完整性研究
J Jacobus,T McQueeny,S Bava et al.
J Jacobus et al.
Structural brain abnormalities have been observed in adolescents with alcohol use disorders but less is known about neuropathological brain characteristics of teens with sub-diagnostic binge drinking or the common pattern of binge drinking ...
Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: a high-resolution magnetic resonance spectroscopy study [0.03%]
高分辨率磁共振波谱在青少年和成人急性甲苯吸入损伤后的神经化学变化研究
Shonagh K O&#x;Leary-Moore,Matthew P Galloway,Andrew P McMechan et al.
Shonagh K O&#x;Leary-Moore et al.
Inhalant abuse in young people is a growing public health concern. We reported previously that acute toluene intoxication in young rats, using a pattern of exposures that approximate abuse patterns of inhalant use in humans, significantly a...
Kimberly Yolton,Jane Khoury,Yingying Xu et al.
Kimberly Yolton et al.
Objective: To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. ...
Comparative Study
Neurotoxicology and teratology. 2009 Nov-Dec;31(6):356-63. DOI:10.1016/j.ntt.2009.07.004 2009
Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats [0.03%]
孕期胆碱补充减轻酒精对胎鼠发育的不良影响
Jennifer D Thomas,Elizabeth J Abou,Hector D Dominguez
Jennifer D Thomas
Prenatal alcohol exposure can lead to a range of physical, neurological, and behavioral alterations referred to as fetal alcohol spectrum disorders (FASD). Variability in outcome observed among children with FASD is likely related to variou...
Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood [0.03%]
新生幼鼠接触尼莫硫磷会破坏成年后大鼠大脑区域的五羟色胺和多巴胺突触功能：高脂饮食的影响
Theodore A Slotkin,Nicola Wrench,Ian T Ryde et al.
Theodore A Slotkin et al.
The consequences of exposure to developmental neurotoxicants are influenced by environmental factors. In the present study, we examined the role of dietary fat intake. We administered parathion to neonatal rats and then evaluated whether a ...
Mammalian wildlife as complementary models in environmental neurotoxicology [0.03%]
哺乳动物野生动物在环境神经毒理学中的互补模型作用
Niladri Basu,Jessica Head
Niladri Basu
The purpose of this paper is to highlight the benefits of mammalian wildlife as models in environmental neurotoxicology. This is first addressed by discussing the general advantages of using mammalian wildlife as models, and highlighting ho...
GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity [0.03%]
GABA受体和神经元膜电位作为化学物质的人急性毒性评估的体外功能终点
Mireia Galofré,Zoila Babot,Daniel A García et al.
Mireia Galofré et al.
Toxicity risk assessment for chemical-induced human health hazards relies mainly on data obtained from animal experimentation, human studies and epidemiology. In vitro testing for acute toxicity based on cytotoxicity assays predicts 70-80% ...
Interpreting epidemiologic studies of developmental neurotoxicity: conceptual and analytic issues [0.03%]
发育神经毒性流行病学研究的概念和分析问题及解读
David C Bellinger
David C Bellinger
This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, par...