Diagnostic and prognostic values of nuclear factor kappa B (NF-κB) and neopterin in the early predication of morbidity and mortality risks in acute organophosphorus intoxicated patients [0.03%]
核转录因子κB与 Neuroporin在急性有机磷中毒早期预后判断中的价值研究
Elzahraa Ahmed Elrefaie Ali,Osama Abdelaziz Hassan,Dalia Mohamed Ali et al.
Elzahraa Ahmed Elrefaie Ali et al.
High rates of morbidity and mortality are linked to acute organophosphorus intoxication. Numerous recent biomarkers are being investigated from a diagnostic and prognostic standpoint. The study was intended to evaluate the role of nuclear f...
Effects of gallic acid on acrylamide-induced endoplasmic reticulum stress, neuroinflammation and neuronal apoptosis in rats [0.03%]
没食子酸对丙烯酰胺致大鼠内质网应激、神经炎症及神经元凋亡的影响
Ömer Faruk Rızvanoğlu,Serkan Yıldırım,Metin Kiliçlioğlu et al.
Ömer Faruk Rızvanoğlu et al.
(ACR)-induced neurotoxicity, focusing on oxidative stress, endoplasmic reticulum (ER) stress, neuroinflammation, and apoptosis mechanisms. Fifty male Sprague-Dawley rats were divided into five groups: Control, ACR, GA50 +ACR, GA100 +ACR, an...
Acute inhibition of NMDA receptor function by bisphenol A and bisphenol F in adult rat brain [0.03%]
双酚A和双酚F通过N-甲基-D天冬氨酸受体急性抑制成年大鼠脑功能
Barbora Hrcka Krausova,Dominika Radostova,Kristyna Maleninska et al.
Barbora Hrcka Krausova et al.
Bisphenol A (BPA), a widely used industrial chemical, is a bioactive environmental contaminant with established neurodevelopmental toxicity. Yet, its effects on the mature brain remain poorly understood. Given the central role of N-methyl-D...
Geniposide ameliorates ferroptosis through the ROS/p38 MAPK/NCOA4/GPX4-mediated ferritinophagy in a co-culture system of HMC3 and SH-SY5Y cells [0.03%]
京尼平苷通过ROS/p38 MAPK/NCOA4/GPX4介导的铁死亡抑制小胶质细胞源性神经元铁死亡
Liang-Jun Wang,Yu-Chin Chang,Li-Mei An et al.
Liang-Jun Wang et al.
Ferritinophagy plays a crucial role in ferroptosis, regulating cell death in response to reactive oxygen species (ROS) and iron metabolism. Geniposide (GEN) is an iridoid glycoside that has been reported to exhibit antioxidant and anti-infl...
Comprehensive lipidomics of Drosophila melanogaster reveal Rotenone exposure induces redox-driven lipid droplet accumulation, systemic lipidome perturbation and differential metabolic prioritization linked to Parkinson's disease [0.03%]
果蝇全面脂质组分析揭示罗塔诺ン暴露诱导的氧化驱动脂肪滴聚集、全身脂质组紊乱及与帕金森病相关的不同代谢优先级
Ashutosh K Tiwari,Priya Rathor,Rajendra Patel et al.
Ashutosh K Tiwari et al.
With the global increase in pesticide use and an aging population, concerns about neurodegenerative disease risk and brain health are intensifying, particularly as environmental toxicants like rotenone emerge as significant hazards. Despite...
The unique effects of chronic exposure to ambient fine particulate matter and indoor radon on subcortical brain morphology in youth [0.03%]
慢性暴露于室外细颗粒物和室内氡气对青年亚皮质脑形态的独特影响
Brittany K Taylor,Monica N Clarke-Smith,Grace E Parolek et al.
Brittany K Taylor et al.
Exposure to environmental toxins can have marked impacts on brain structure and function, particularly among children and adolescents for whom vulnerability to toxic exposures is the greatest. Herein, we explored whether there were unique a...
Adaptation and test-retest reliability of a mobile neurocognitive battery for assessing neurotoxicity in rural children in Bangladesh [0.03%]
在孟加拉国农村儿童中适应和测试重复可靠性的移动神经认知电池用于评估神经毒性
Rasheda Sultana,Md Shiblur Rahaman,Berna Rahi et al.
Rasheda Sultana et al.
Traditional neurocognitive assessments are generally time-consuming, labor-intensive, and often infeasible in resource-poor research settings. Cost-effective and culturally adaptable mobile neurocognitive test batteries could be ideal for v...
Repeated neonatal sevoflurane exposure causes adolescent anxiety/depression via microglial P2Y12R-Wnt/β-catenin pathway-mediated neurogenesis deficits [0.03%]
重复的新生儿吸入七氟醚致青春期焦虑/抑郁样的行为及海马神经发生缺陷相关机制研究
Xiaoqing Wang,Hang Zhao,Huirong Dai et al.
Xiaoqing Wang et al.
Sevoflurane is the most commonly used inhaled anesthetic in pediatric and obstetric practice. However, early-life multiple sevoflurane exposure may increase long-term neurodevelopmental risks, though the underlying mechanisms remain incompl...
The zebrafish Visual and Acoustic Motor Response (VAMR) assay has the potential to add value to the Developmental Neurotoxicity In Vitro Battery (DNT IVB) [0.03%]
斑马鱼视觉和听觉运动反应（VAMR）试验有可能增加发育神经毒理学体外试验电池（DNT IVB）的价值
Julia Spath,Jana Raab,Jana Schor et al.
Julia Spath et al.
Less than 150 chemicals have been evaluated for their potential to cause developmental neurotoxicity (DNT) using OECD rodent-based test guidelines. The DNT in vitro battery (DNT IVB), comprised of 17 human or rodent cell-based assays, is a ...
Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1 [0.03%]
circRNA2092/miR-873a-5p/KEAP1调控小胶质细胞表型介导地氟醚加重新生小鼠神经炎症和氧化应激反应
Yanan Li,Juan Du,Jiajie Zhang et al.
Yanan Li et al.
Repeat sevoflurane exposure can cause developmental neurotoxicity while its underlying mechanism is still ambiguous. Contemporary research has increasingly highlighted the regulatory role of non-coding RNAs (ncRNAs) in the development of ne...