A Single Nucleotide Polymorphism That Affects Oligodendroglial Lineage Cells May Augment the Consequences of Neurotoxicants [0.03%]
影响少突胶质细胞系细胞的单核苷酸多态性可能会加剧神经毒性物质的影响
Ronald D Poretz
Ronald D Poretz
An increasing number of toxicants are found to target oligodendroglia lineage cells. Among them, environmental lead and oral alcohol reduce oligodendrogenesis and affect oligodendrocyte precursor cells (OPCs). OPCs perform a multitude of fu...
Imbalance of the AKT/MAPK signaling axis mediates the exacerbation of Alzheimer's disease pathology by simulated particulate air pollution from Shihezi in APP/PS1 mice [0.03%]
来自石河子的模拟颗粒物空气污染通过加剧APP / PS1小鼠中阿尔茨海默病病理学的恶化来介导AKT / MAPK信号轴失衡
Xuening Li,Linglong Meng,Qiang Niu et al.
Xuening Li et al.
This study investigated the mechanisms by which a region-specific simulated PM2.5 from Shihezi, China, exacerbates Alzheimer's disease (AD) pathology, focusing on the protein kinase B (AKT)/mitogen-activated protein kinase (MAPK) signaling ...
An investigation into the use of Caenorhabditis elegans as a model organism for nerve agent exposure research [0.03%]
有机体被用作模型进行神经毒剂暴露研究的调查
Johanna Haszczyn,A Christopher Green,Lindy Holden-Dye et al.
Johanna Haszczyn et al.
Nerve agents exert their toxicological effects via inhibition of acetylcholinesterase (AChE). This inhibition results in excessive cholinergic signalling, which can result in fatality through cessation of breathing. Current therapies for ne...
Astragaloside IV attenuates cisplatin-induced ototoxicity by preserving mitochondrial function and activating the Nrf2 signaling pathway [0.03%]
黄芪皂苷IV通过保护线粒体功能和激活Nrf2信号通路来缓解顺铂引起的耳毒性
Tan Wang,Daquan Wu,Peng Wang et al.
Tan Wang et al.
Background: Cisplatin-induced ototoxicity represents a major dose-limiting adverse effect of chemotherapy, leading to irreversible sensorineural hearing loss. Astragaloside IV (AS-IV), a bioactive saponin derived from Ast...
Polychlorinated biphenyls (PCBs) exposure and cognitive function in adults: A systematic review of epidemiologic evidence and risk of bias assessment [0.03%]
多氯联苯(PCBs)暴露与成人认知功能的流行病学证据及偏倚风险评估系统评价
Zhenchun Yang,Jiayuan Hao,Hannah Nash et al.
Zhenchun Yang et al.
Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants known for their environmental longevity and neurotoxicity. Although developmental exposure has been extensively studied, the cognitive impacts...
Structural neuroimaging of the planning network in Inuit adolescents prenatally exposed to lead [0.03%]
接触铅的因纽特青少年计划网络的结构性神经影像学研究
Mathieu Fornasier-Bélanger,Gina Muckle,Pierre Ayotte et al.
Mathieu Fornasier-Bélanger et al.
Exposure to lead has been linked to alterations in cortical organization and impaired executive function. However, neural correlates of the association between lead exposure and cognitive planning remain poorly characterized. This study inv...
Brain MRI iron deposition and serum iron with multiple sclerosis: Evidence from a Mendelian randomization study [0.03%]
基于孟德尔随机化研究的多发性硬化症脑MRI铁沉积和血清铁证据
Tao Wu,Lihua Wang,Yuze Cao et al.
Tao Wu et al.
Background: Accumulating evidence suggests abnormal iron deposition in the brains of patients with multiple sclerosis (MS). However, the causal relevance of brain iron deposition, as well as its relationship with systemic...
Natural bioactive compounds as therapeutic agents against phthalate neurotoxicity: Cellular and molecular signaling pathways [0.03%]
用于治疗酞酸盐神经毒性的天然生物活性化合物：细胞和分子信号通路
Oluwadarasimi E Atanda,Oluwatobiloba Faith Da-Silva,Peace O Akanbi et al.
Oluwadarasimi E Atanda et al.
Phthalates are ubiquitous environmental contaminants and endocrine-disrupting chemicals used as plasticizers in consumer products, medical devices, and industrial materials. Evidence from in vitro experiments, animal models, and epidemiolog...
Crebanine attenuates copper neurotoxicity via PACS-2 upregulation and TXNIP/TRPV1 axis suppression [0.03%]
Crebanine通过上调PACS-2和抑制TXNIP / TRPV1轴缓解铜神经毒性
Osama A Mohammed,Abdullah A Hashish,Ahmed Soliman Doghish et al.
Osama A Mohammed et al.
Continuous copper (Cu) deposition in the brain induces endoplasmic reticulum (ER) stress by activating p38-MAPK, which triggers the p-PERK-ATF4-CHOP cascade. Besides, Cu provokes oxidative stress, stimulating the TXNIP/TRPV1 to promote chro...
High sensitivity of iPSC-derived motor neurons to the human-relevant botulinum neurotoxin serotypes E and F [0.03%]
人源相关肉毒神经毒素E和F型对诱导多能干细胞来源的运动神经元高敏感性研究
Maren Schenke,Alice Westphal,Jasmin Weisemann et al.
Maren Schenke et al.
Botulinum neurotoxins (BoNTs) are the most potent biological toxins known and widely used as biopharmaceuticals. Yet pharmaceutical potency testing still relies largely on the mouse bioassay, raising ethical concerns and conflicting with 3 ...