Diesel exhaust particles induce lasting and age-dependent damage to the brain in Drosophila melanogaster [0.03%]
柴油尾气颗粒物可诱导果蝇大脑持久性年龄依赖型损伤
Ranchana Yeewa,Siwat Poompouang,Kornravee Photichai et al.
Ranchana Yeewa et al.
Diesel exhaust particles (DEP), major air pollutants emitted from automobile engines, contain numerous toxic compounds. Although the adverse effects of DEP exposure on the respiratory and cardiovascular systems are well documented, its impa...
Dynamic dose-time proteomic profiling of cadmium exposure in rat prefrontal cortex [0.03%]
暴露于不同剂量镉下的大鼠前额叶皮层动态蛋白质组学研究
Hu Zhijian,Feng Han,Hao Gao et al.
Hu Zhijian et al.
Background: Cadmium (Cd) is a well-recognized neurotoxic metal whose effects on the central nervous system accumulate with both exposure intensity and duration. However, how dose and time jointly sculpt brain proteome tra...
Lysosomal dysfunction contributes to lead (Pb) and high-fat diet (HFD)-induced neuronal apoptosis: A link with cathepsin B [0.03%]
溶酶体功能障碍促进铅(Pb)和高脂饮食(HFD)诱导的神经元凋亡：与半乳糖苷酶B的相关性
Yongke Yuan,Mengchen Liu,Mengdi Zhai et al.
Yongke Yuan et al.
Environmental lead (Pb) exposure and high-fat diet (HFD) intake are known to trigger massive neuronal apoptosis that contributes to neurologic dysfunction. Previous studies mainly focused on isolated mitochondrial dysfunction, autophagy-lys...
Lead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve [0.03%]
铅(Pb)暴露引起小鼠视网膜和视神经中特定类型细胞的变化
Labony Khandokar,Luke L Liu,Wei Zheng et al.
Labony Khandokar et al.
Chronic exposure to lead (Pb) is known to cause deficits in neuronal function across the nervous system, including the visual nervous system. Visual deficits have been observed in both humans and rodent models following Pb exposure. However...
Adverse effects and mechanisms induced by legacy, emerging per- and polyfluoroalkyl substances on neuron: Human exposure, adverse outcomes [0.03%]
传统和新型全氟和多氟烷基物质对神经元的毒性效应及机制研究进展
Rencan Zeng,Guanghua Mao,Yao Chen et al.
Rencan Zeng et al.
Per- and polyfluoroalkyl substances (PFASs), due to their distinctive physicochemical characteristics, are emerging pollutants that are widely used as raw materials in industrial production, leading to their ubiquitous presence in the envir...
Gut Microbiota: A Critical Regulator of Oxaliplatin-Induced Peripheral Neurotoxicity Development [0.03%]
肠道菌群：调控奥沙利铂诱导的外周神经毒性的关键因素
Zhen Liu,TingRong Zhang,SiMin Wang et al.
Zhen Liu et al.
Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a common dose-limiting toxicity that significantly affects patients' quality of life. Although neuroinflammation has been implicated, the precise contributio...
Arsenic attenuates responsiveness to inflammatory stimuli in the SIM-A9 microglial cell line [0.03%]
砷可降低SIM-A9微胶质细胞系对炎症刺激的反应性
Luyu Wang,Lidan Zhao,James Boyett et al.
Luyu Wang et al.
Arsenic (As) is a major public health threat, with more than 200 million people at risk of consuming drinking water that exceeds World Health Organization safety guidelines. Given that inorganic arsenic (iAs) is linked to various neuropsych...
Reconsidering principal component analysis in neurodevelopmental studies: A call for advanced frameworks [0.03%]
重新考虑神经发育研究中的主成分分析：呼吁采用先进框架
Souichi Oka,Ryota Ono,Yoshiyasu Takefuji
Souichi Oka
Bodin et al. (2025) provide valuable insights into neurodevelopmental vulnerability by examining radiofrequency electromagnetic fields (RF‑EMF) exposure during early life. Their integrative design, combining whole-body exposure with endpoi...
Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning [0.03%]
一氧化碳中毒猪模型中的剂量依赖性脑代谢障碍
Alistair Lewis,Rodrigo M Forti,Tiffany S Ko et al.
Alistair Lewis et al.
Carbon monoxide (CO) poisoning is a leading cause of environmental poisoning in the United States and can impair cellular metabolism through both hypoxia and direct mitochondrial toxicity, particularly via inhibition of cytochrome c oxidase...
Untangling the Mercury Neurotoxicity Puzzle in the Amazon: An Exposome-Based Perspective on Co-Exposure, Nutrition, and Causality [0.03%]
亚马逊汞神经毒性之谜的解开——基于暴露组学的联合作用、营养和因果关系的新视角
Fernando Barbosa Jr,José L Domingo,Michael Aschner
Fernando Barbosa Jr
For more than four decades, research on Amazonian riverine populations has been shaped by a single dominant narrative: that mercury (Hg) exposure from fish consumption is the primary driver of neurotoxic risk. While this perspective was piv...