Astragaloside IV attenuates cisplatin-induced ototoxicity by preserving mitochondrial function and activating the Nrf2 signaling pathway [0.03%]
黄芪皂苷IV通过保护线粒体功能和激活Nrf2信号通路来缓解顺铂引起的耳毒性
Tan Wang,Daquan Wu,Peng Wang et al.
Tan Wang et al.
Background: Cisplatin-induced ototoxicity represents a major dose-limiting adverse effect of chemotherapy, leading to irreversible sensorineural hearing loss. Astragaloside IV (AS-IV), a bioactive saponin derived from Ast...
Polychlorinated biphenyls (PCBs) exposure and cognitive function in adults: A systematic review of epidemiologic evidence and risk of bias assessment [0.03%]
多氯联苯(PCBs)暴露与成人认知功能的流行病学证据及偏倚风险评估系统评价
Zhenchun Yang,Jiayuan Hao,Hannah Nash et al.
Zhenchun Yang et al.
Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants known for their environmental longevity and neurotoxicity. Although developmental exposure has been extensively studied, the cognitive impacts...
Structural neuroimaging of the planning network in Inuit adolescents prenatally exposed to lead [0.03%]
接触铅的因纽特青少年计划网络的结构性神经影像学研究
Mathieu Fornasier-Bélanger,Gina Muckle,Pierre Ayotte et al.
Mathieu Fornasier-Bélanger et al.
Exposure to lead has been linked to alterations in cortical organization and impaired executive function. However, neural correlates of the association between lead exposure and cognitive planning remain poorly characterized. This study inv...
Brain MRI iron deposition and serum iron with multiple sclerosis: Evidence from a Mendelian randomization study [0.03%]
基于孟德尔随机化研究的多发性硬化症脑MRI铁沉积和血清铁证据
Tao Wu,Lihua Wang,Yuze Cao et al.
Tao Wu et al.
Background: Accumulating evidence suggests abnormal iron deposition in the brains of patients with multiple sclerosis (MS). However, the causal relevance of brain iron deposition, as well as its relationship with systemic...
Natural bioactive compounds as therapeutic agents against phthalate neurotoxicity: Cellular and molecular signaling pathways [0.03%]
用于治疗酞酸盐神经毒性的天然生物活性化合物：细胞和分子信号通路
Oluwadarasimi E Atanda,Oluwatobiloba Faith Da-Silva,Peace O Akanbi et al.
Oluwadarasimi E Atanda et al.
Phthalates are ubiquitous environmental contaminants and endocrine-disrupting chemicals used as plasticizers in consumer products, medical devices, and industrial materials. Evidence from in vitro experiments, animal models, and epidemiolog...
Crebanine attenuates copper neurotoxicity via PACS-2 upregulation and TXNIP/TRPV1 axis suppression [0.03%]
Crebanine通过上调PACS-2和抑制TXNIP / TRPV1轴缓解铜神经毒性
Osama A Mohammed,Abdullah A Hashish,Ahmed Soliman Doghish et al.
Osama A Mohammed et al.
Continuous copper (Cu) deposition in the brain induces endoplasmic reticulum (ER) stress by activating p38-MAPK, which triggers the p-PERK-ATF4-CHOP cascade. Besides, Cu provokes oxidative stress, stimulating the TXNIP/TRPV1 to promote chro...
High sensitivity of iPSC-derived motor neurons to the human-relevant botulinum neurotoxin serotypes E and F [0.03%]
人源相关肉毒神经毒素E和F型对诱导多能干细胞来源的运动神经元高敏感性研究
Maren Schenke,Alice Westphal,Jasmin Weisemann et al.
Maren Schenke et al.
Botulinum neurotoxins (BoNTs) are the most potent biological toxins known and widely used as biopharmaceuticals. Yet pharmaceutical potency testing still relies largely on the mouse bioassay, raising ethical concerns and conflicting with 3 ...
Capsaicin attenuates methylglyoxal-induced neurotoxicity via the ATF4-Sestrin2 signaling and direct scavenging of methylglyoxal [0.03%]
辣椒素通过激活ATF4-硒蛋白2信号通路和直接清除甲基甘油醛削弱甲基甘油醛诱导的神经毒性
Shin Koike,Haruka Kajiki,Momoka Kamegai et al.
Shin Koike et al.
Methylglyoxal (MGO) is a highly reactive dicarbonyl byproduct of glycolysis. It accumulates under pathological conditions and exhibits pronounced cytotoxic effects in neuronal cells. Capsaicin, a dietary vanilloid compound and agonist of th...
Long-term particulate matter exposure accelerates cognitive decline and increases incident mild cognitive impairment in middle-aged and older adults [0.03%]
长期颗粒物暴露会加速中老年人认知能力下降并增加轻度认知障碍患病风险
Mingkai Li,Chenhui Lv,Chenyang Li et al.
Mingkai Li et al.
Background: Inhalable particulate matter (PM) has been linked to cognitive decline, but evidence on size-specific associations between PM and cognitive function and mild cognitive impairment (MCI) in middle-aged and older...
The Role of sGC-cGMP-PKG Signaling Pathway-Mediated Excitotoxicity in Delayed Encephalopathy After Carbon Monoxide Poisoning [0.03%]
一氧化碳中毒迟发性脑病中sGC-cGMP-PKG信号通路介导的兴奋毒性的作用机制研究
Xin Luo,Bingxue He,Fenghong Zhao et al.
Xin Luo et al.
This study investigated the role of soluble guanylate cyclase-cyclic guanosine monophosphate-protein kinase G (sGC-cGMP-PKG) signaling pathway in the regulation of carbon monoxide (CO) on glutamate neurotransmitter system and neuronal excit...