Best Practices in Neurotoxicology Research Must Account for Spontaneous Brain Malformations in Rodent Models [0.03%]
啮齿类模型中自发性脑畸形须纳入神经毒理学研究的最佳实践范围内考虑
Justin T Popp,Raddy L Ramos
Justin T Popp
Spontaneous neocortical and cerebellar heterotopia are present in rat and mouse strains commonly used in neurotoxicology research. These malformations reflect neuronal migration defects during neocortical and cerebellar development that are...
Comparing effects of gaseous vs. particulate components of traffic-related air pollution on Alzheimer's disease biomarkers in a genetically susceptible rat model [0.03%]
比较气态和颗粒态交通相关空气污染成分对遗传易感性大鼠模型阿尔茨海默病生物标志物的影响
Nathifa Nasim,Mei-Yun Cheng,Heui Hye Park et al.
Nathifa Nasim et al.
Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer's disease (AD) and AD-related dementia (ADRD), and while experimental animal studies corroborate this association, most utilized exposure paradigm...
Simulated wildfire smoke particulate matter elicits STING-dependent astrocyte-mediated inflammatory signaling and neurotoxicity [0.03%]
模拟野火烟雾颗粒物诱发STING依赖性的星形胶质细胞介导的炎症信号和神经毒性
Adam J Schuller,Abigail M Bibb,Megan R Hager et al.
Adam J Schuller et al.
Changing global wildfire landscapes necessitate exploration of the effects of exposure to wildfire smoke on health and disease. Exposure to this toxicant is not only associated with acute cardiopulmonary dysfunction, but is increasingly rec...
A Critical Review of Potential Modifiers of Air Pollutant Associations with Dementia and Related Outcomes [0.03%]
潜在修饰因素对空气污染物与痴呆及相关结果之间关联影响的批判性评论
JeongWon Han,Yina Li,Sangji Lee et al.
JeongWon Han et al.
Background: Air pollution has been linked with poor cognitive and brain health, including Alzheimer's Disease and Related Dementia (ADRD). However, whether specific individuals are more susceptible than others remains unc...
Early postnatal exposure to permethrin and deltamethrin mixtures induces sex-specific hippocampal neurobehavioral and neurochemical alterations in adulthood [0.03%]
早孕期接触溴氰菊酯和右旋苯氧威混合物可致成年期海马神经行为及神经化学性别差异性改变
Sabrine Ben Slimene,Khadija Boukholda,Rahma Ammar et al.
Sabrine Ben Slimene et al.
Pyrethroid insecticides, including deltamethrin and permethrin, are known for their individual toxic effects; however, evidence regarding their combined toxicity during early developmental stages remains limited. The present study aimed to ...
Ozone in Neurodegeneration: An Environmental Toxicant or a Therapeutic Hormetin? [0.03%]
臭氧在神经退行性疾病中的作用：环境毒物还是治疗 hormetin？
Caterina Vinciguerra,Mariangela Cernera,Marika Comegna et al.
Caterina Vinciguerra et al.
Ozone (also known as triatomic oxygen [O₃]) is an allotropic form of oxygen commonly found in the atmosphere. Growing epidemiological and experimental evidence indicates that chronic exposure to environmental ozone (as a pollutant) may wor...
Toxic metal exposure and biomarkers of neurotoxic effects: A study in metal recycling workers [0.03%]
金属回收工人中的有毒金属暴露及其神经毒性生物标志物研究
Meşide Gündüzöz,Murat Büyükşekerci,Osman Gökhan Özakıncı et al.
Meşide Gündüzöz et al.
Background: Occupational exposure to toxic metals is a critical global health concern, particularly in the metal scrap recycling industry where simultaneous exposure to complex mixtures is common. Chronic exposure to thes...
Disruption of Hippocampal Synaptic Plasticity by Chronic Ethanol Exposure: A Narrative Review of Neurotoxic Adverse Outcome Pathways [0.03%]
慢性酒精暴露干扰海马突触可塑性的分子机制及神经毒性不良结局通路：叙事性文献复习
Fatemeh Seyedi,Mahdiyeh Hedayati-Moghadam,Mojgan Heidari et al.
Fatemeh Seyedi et al.
Chronic is a major neurotoxicant that disrupts hippocampal synaptic plasticity, leading to persistent cognitive deficits. This narrative review maps the adverse outcome pathways (AOPs) through which ethanol impairs synaptic function, primar...
Preliminary evidence of polyvinyl chloride microplastics inducing ferroptosis in the cerebral cortex of ducks [0.03%]
聚氯乙烯微塑料诱导鸭脑皮质细胞铁死亡的初步证据
Li Wang,Hongsheng Song,Tao Wang et al.
Li Wang et al.
Ferroptosis, a type of regulated cell death, is frequently observed in mammalian brain cortical injuries and diseases linked to iron metabolism disorders. Recent evidence suggests that microplastic exposure may trigger such ferroptosis-rela...
Postnatal particulate matter exposure alters developmental milestones and brain gene expression in apoE transgenic mice in a sex- and genotype-dependent manner [0.03%]
产后颗粒物暴露以性别和基因型依赖的方式改变载脂蛋白E转基因小鼠的发育指标及大脑基因表达
Rocío Rodulfo-Cárdenas,Judit Biosca-Brull,Séfora Barberà-Parada et al.
Rocío Rodulfo-Cárdenas et al.
Air pollution, with particulate matter (PM) as one of its most critical environmental contaminants, represents a major global health threat and a leading cause of premature mortality. PM can reach the central nervous system (CNS) and has be...