Power Calculations for Larval Zebrafish in Light-Dark Transition Test for Developmental Neurotoxicity [0.03%]
斑马鱼幼虫在光暗过渡试验中的功效计算用于开发神经毒性
Kathryn S Konrad,Katherine Allen-Moyer,Lee Ellis et al.
Kathryn S Konrad et al.
The link between environmental chemical exposures and neurodevelopmental disorders such as autism and attention-deficit/hyperactivity disorder underscores the need to develop efficient developmental neurotoxicity (DNT) assays for chemical e...
Zebra_K+: High-Throughput Analysis of Acoustic Startle Response Plasticity in Zebrafish Embryos and Larvae in Neurotoxicity Testing [0.03%]
斑马鱼胚胎和幼体神经毒性测试中声音惊跳反应可塑性的高通量分析(Zebra_K+)
Niki Tagkalidou,Ouwais Aljabasini,Sergi Pujol et al.
Niki Tagkalidou et al.
The acoustic startle response (ASR) is a conserved sensorimotor reflex widely used to investigate neural plasticity, sensorimotor gating, and neurotoxicity. While zebrafish is an established vertebrate model for ASR analysis, most existing ...
Pamela J Lein,Aaron B Bowman,Zhengyu Cao et al.
Pamela J Lein et al.
A critical component of evaluating whether a chemical can cause human neurotoxicity is hazard identification, which typically involves a comprehensive literature search to identify and synthesize epidemiological, animal, and mechanistic dat...
Understanding similarities and differences of FASD in three zebrafish populations [0.03%]
理解三种斑马鱼群体中FASD的相似性和差异性
João Paulo Medeiros Mamede,Maria Clara Galvão-Pereira,Augusto Monteiro de Souza et al.
João Paulo Medeiros Mamede et al.
Alcohol consumption during pregnancy is a major public health concern, as prenatal exposure to ethanol can disrupt embryonic development and lead to Fetal Alcohol Spectrum Disorders (FASD). These disorders are characterized by a wide range ...
Methylene blue protects oligodendroglial cell models of multiple systems atrophy against hydrogen peroxide-mediated oxidative stress [0.03%]
亚甲蓝保护多系统萎缩小胶质细胞模型免受过氧化氢介导的氧化应激损伤
Kayla M Elias,William F Muliawan,Muriel J Moon et al.
Kayla M Elias et al.
Multiple Systems Atrophy (MSA) is a rare, neurodegenerative disorder associated with impaired alpha (α)-synuclein (α-syn) protein function. α-syn can aggregate within oligodendrocytes, activating oxidative stress pathways and ultimately ...
FTH1-mediated iron dysregulation and ferroptosis in manganese-induced neurotoxicity [0.03%]
Mn诱导的神经毒性的FTH1介导的铁代谢紊乱及铁死亡
Xiaoli Ma,Shengtao Wei,Fangfei Li et al.
Xiaoli Ma et al.
Excessive environmental manganese (Mn) exposure has been implicated in neurological disorders, with iron homeostasis imbalance emerging as a crucial aspect in neurodegeneration diagnosis and therapy. However, the intricate mechanisms underl...
Formononetin protects against oxaliplatin-induced peripheral neurotoxicity via Nrf2/HO-1 antioxidant pathway without impairing anticancer efficacy [0.03%]
染料木素通过Nrf2/HO-1抗氧化途径对抗奥沙利铂诱导的外周神经毒性且不会影响抗癌功效
Yang-Chen Chang,Wan-Hsuan Lin,Horng-Huey Ko et al.
Yang-Chen Chang et al.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and intolerable adverse effect of oxaliplatin and paclitaxel. The intolerance to CIPN symptoms often leads to poor compliance and treatment discontinuation, jeopardizing survival...
Chemotherapy-induced cognitive impairment (CICI): Cisplatin's effects on neurotransmitter regulation and oxidative stress in Drosophila melanogaster [0.03%]
顺铂诱发的氧化应激和神经递质紊乱导致果蝇化疗相关性认知障碍的研究
Raifa Abdul Aziz,Deepa Mugudthi Venugopal,Avinash Kundadka Kudva et al.
Raifa Abdul Aziz et al.
Chemotherapy-induced cognitive impairment (CICI), commonly known as "chemo brain," is a significant and persistent complication of cancer therapy, characterized by memory deficits and broader cognitive dysfunction. Despite its prevalence am...
Long-term Air Pollution Exposure and Cognitive Impairment Risk in Chinese Middle-aged and Older Adults [0.03%]
长期空气污染暴露对中国中老年人认知障碍风险的影响研究
Shengqiang Xie,Shichao Su,Wenxuan Li et al.
Shengqiang Xie et al.
This prospective cohort study quantified the longitudinal associations between long-term exposure to multiple air pollutants and cognitive impairment risk among China's middle-aged and older adults. Leveraging data from 10,584 participants ...
The "Route Cause" of Methotrexate-Induced Brain Structure Changes in a Juvenile Mouse Model: Comparison of Systemic and CNS-Targeted Chemotherapy [0.03%]
介观成像揭示甲氨蝶呤所致小鼠脑结构改变的“路线原因”：全身化疗和中枢神经系统定向化疗的比较
Sun Eui Choi,Tiffany Ayoub,Gail Lee et al.
Sun Eui Choi et al.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and while five-year survival rates exceed 90%, survivors display neurocognitive deficits. Magnetic resonance imaging (MRI) measurements indicate smaller volume across th...