Reduced hepcidin expression leads to iron accumulation in the substantia nigra of rotenone-induced rat model of Parkinson's disease [0.03%]
他莫西林表达降低导致罗tenone诱导的帕金森病大鼠模型黑质铁沉积增多
Feimi Li,Christopher Qian,Qian Guo et al.
Feimi Li et al.
Despite years of research, it is still unclear why iron accumulates in the substantia nigra (SN) of Parkinson's disease (PD) animal models and PD patients. To address this, we investigated the changes in serum iron, iron content, transferri...
Combined exposure to 6PPD and 6PPD-Q induced neurotoxic responses in zebrafish and SH-SY5Y cells: evidence from neurotransmitter disruption, oxidative damage, and apoptosis [0.03%]
6PPD及其代谢物6PPD-Q联合暴露诱导斑马鱼和SH-SY5Y细胞神经毒性响应：来自神经递质紊乱、氧化损伤和凋亡的证据
Ziwei Wang,Shutao Wang,Wanlun Li et al.
Ziwei Wang et al.
The rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its quinone derivative (6PPD-Q) are coexisting environmental contaminants with documented neurobehavioral effects. However, the neurotoxic consequences ari...
Mitochondria-driven oxidative stress mediates cyproconazole-induced genotoxicity, caspase-dependent apoptosis, and glial neuroinflammation in human neuronal and glial cell lines [0.03%]
线粒体驱动的氧化应激介导了氮氯苯唑诱导的人神经和胶质细胞系中的遗传毒性、半胱天冬酶依赖性凋亡和胶质神经炎症
Mnassri Asma,Chaabani Hanen,Abderrazk Fatma et al.
Mnassri Asma et al.
Cyproconazole (CYPRO), a triazole fungicide widely used in agriculture, poses potential risks to the central nervous system, yet its neurotoxic mechanisms remain poorly characterized. This study provides the first integrative mechanistic in...
Exploratory transcriptomic and network-based analysis of methylmercury exposure in human neuronal developmental models using GEO datasets and toxicogenomic resources [0.03%]
基于GEO数据集和毒转组资源的人类神经发育模型甲基汞暴露的探索性转录组和网络分析
Danna Gomez-Caballero,Jesus Olivero-Verbel
Danna Gomez-Caballero
Background: Methylmercury (MeHg) is a well-recognized environmental neurotoxicant with a marked impact on neurodevelopment. However, studies integrating stage-specific transcriptomic responses in human neuronal developmen...
Association between metal exposure and depressive symptoms: The mediating role of fatty acids [0.03%]
金属暴露与抑郁症状的关系：脂肪酸的中介作用
Yun Qiu,Yong-Xiang Tang,Zengliang Ruan et al.
Yun Qiu et al.
Background: Previous studies have shown that metal exposure has been linked to depressive symptoms, with fatty acids potentially playing a role in this connection. Moreover, evidence on broader metal mixtures remains limi...
Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment [0.03%]
通过整合涵盖神经发育关键细胞事件的新方法（NAM）数据优先对发育性神经毒性的化学品进行分类
Laura A Hall,Jui-Hua Hsieh,Skylar W Marvel et al.
Laura A Hall et al.
Thousands of chemicals have not been assessed for developmental neurotoxicity (DNT) despite potential human exposure, prompting efforts to screen chemicals for possible DNT hazard using in vitro approaches. Ninety-five chemicals were screen...
Radon-related increases in depressive symptoms are explained by amygdala morphology and external locus of control [0.03%]
与杏仁核形态学和外在控制源有关的氡相关的抑郁症状增加
Grace E Parolek,Monica N Clarke-Smith,Saige C Rasmussen et al.
Grace E Parolek et al.
Objective: Environmental toxins have been linked to depressive symptoms, potentially via brain morphology and cognition. In particular, the amygdala acts as an affective hub and may be especially sensitive to environmenta...
Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model [0.03%]
急性木烟暴露与加速卵巢衰竭小鼠模型海马转录本反应相关的研究
Sydnee J Yazzie,Mijung Oh,Eunju Lim et al.
Sydnee J Yazzie et al.
Background: Wildfire events are increasing in frequency and intensity, and aging individuals demonstrate heightened biological susceptibility to air pollution exposures including increased risk of neurological sequelae. D...
The association between exposure to flame retardants and cognitive function in the elderly: Unveiling potential intervention strategies [0.03%]
阻燃剂暴露与老年人认知功能障碍的关联：探索潜在干预策略
Yu Liu,Shiqi Luo,Jianjun Liu et al.
Yu Liu et al.
Background: Human beings have been widely exposed to various types of flame retardants, but little is known about their effects on cognitive function in the elderly. ...
Cameron P Hamson,Morgan L Atkinson,Troy A Roepke
Cameron P Hamson
As the implementation of 'sex as a biological variable' policies have been enacted across the world, the study of sex differences or comparisons across the sexes has steadily increased. In the field of neurotoxicology, the study of sex-depe...