Lead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve [0.03%]
铅(Pb)暴露引起小鼠视网膜和视神经中特定类型细胞的变化
Labony Khandokar,Luke L Liu,Wei Zheng et al.
Labony Khandokar et al.
Chronic exposure to lead (Pb) is known to cause deficits in neuronal function across the nervous system, including the visual nervous system. Visual deficits have been observed in both humans and rodent models following Pb exposure. However...
Adverse effects and mechanisms induced by legacy, emerging per- and polyfluoroalkyl substances on neuron: Human exposure, adverse outcomes [0.03%]
传统和新型全氟和多氟烷基物质对神经元的毒性效应及机制研究进展
Rencan Zeng,Guanghua Mao,Yao Chen et al.
Rencan Zeng et al.
Per- and polyfluoroalkyl substances (PFASs), due to their distinctive physicochemical characteristics, are emerging pollutants that are widely used as raw materials in industrial production, leading to their ubiquitous presence in the envir...
Gut Microbiota: A Critical Regulator of Oxaliplatin-Induced Peripheral Neurotoxicity Development [0.03%]
肠道菌群：调控奥沙利铂诱导的外周神经毒性的关键因素
Zhen Liu,TingRong Zhang,SiMin Wang et al.
Zhen Liu et al.
Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a common dose-limiting toxicity that significantly affects patients' quality of life. Although neuroinflammation has been implicated, the precise contributio...
Arsenic attenuates responsiveness to inflammatory stimuli in the SIM-A9 microglial cell line [0.03%]
砷可降低SIM-A9微胶质细胞系对炎症刺激的反应性
Luyu Wang,Lidan Zhao,James Boyett et al.
Luyu Wang et al.
Arsenic (As) is a major public health threat, with more than 200 million people at risk of consuming drinking water that exceeds World Health Organization safety guidelines. Given that inorganic arsenic (iAs) is linked to various neuropsych...
Reconsidering principal component analysis in neurodevelopmental studies: A call for advanced frameworks [0.03%]
重新考虑神经发育研究中的主成分分析：呼吁采用先进框架
Souichi Oka,Ryota Ono,Yoshiyasu Takefuji
Souichi Oka
Bodin et al. (2025) provide valuable insights into neurodevelopmental vulnerability by examining radiofrequency electromagnetic fields (RF‑EMF) exposure during early life. Their integrative design, combining whole-body exposure with endpoi...
Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning [0.03%]
一氧化碳中毒猪模型中的剂量依赖性脑代谢障碍
Alistair Lewis,Rodrigo M Forti,Tiffany S Ko et al.
Alistair Lewis et al.
Carbon monoxide (CO) poisoning is a leading cause of environmental poisoning in the United States and can impair cellular metabolism through both hypoxia and direct mitochondrial toxicity, particularly via inhibition of cytochrome c oxidase...
Untangling the Mercury Neurotoxicity Puzzle in the Amazon: An Exposome-Based Perspective on Co-Exposure, Nutrition, and Causality [0.03%]
亚马逊汞神经毒性之谜的解开——基于暴露组学的联合作用、营养和因果关系的新视角
Fernando Barbosa Jr,José L Domingo,Michael Aschner
Fernando Barbosa Jr
For more than four decades, research on Amazonian riverine populations has been shaped by a single dominant narrative: that mercury (Hg) exposure from fish consumption is the primary driver of neurotoxic risk. While this perspective was piv...
A Single Nucleotide Polymorphism That Affects Oligodendroglial Lineage Cells May Augment the Consequences of Neurotoxicants [0.03%]
影响少突胶质细胞系细胞的单核苷酸多态性可能会加剧神经毒性物质的影响
Ronald D Poretz
Ronald D Poretz
An increasing number of toxicants are found to target oligodendroglia lineage cells. Among them, environmental lead and oral alcohol reduce oligodendrogenesis and affect oligodendrocyte precursor cells (OPCs). OPCs perform a multitude of fu...
Imbalance of the AKT/MAPK signaling axis mediates the exacerbation of Alzheimer's disease pathology by simulated particulate air pollution from Shihezi in APP/PS1 mice [0.03%]
来自石河子的模拟颗粒物空气污染通过加剧APP / PS1小鼠中阿尔茨海默病病理学的恶化来介导AKT / MAPK信号轴失衡
Xuening Li,Linglong Meng,Qiang Niu et al.
Xuening Li et al.
This study investigated the mechanisms by which a region-specific simulated PM2.5 from Shihezi, China, exacerbates Alzheimer's disease (AD) pathology, focusing on the protein kinase B (AKT)/mitogen-activated protein kinase (MAPK) signaling ...
An investigation into the use of Caenorhabditis elegans as a model organism for nerve agent exposure research [0.03%]
有机体被用作模型进行神经毒剂暴露研究的调查
Johanna Haszczyn,A Christopher Green,Lindy Holden-Dye et al.
Johanna Haszczyn et al.
Nerve agents exert their toxicological effects via inhibition of acetylcholinesterase (AChE). This inhibition results in excessive cholinergic signalling, which can result in fatality through cessation of breathing. Current therapies for ne...