Mechanisms of Nicotine Toxicity and Addiction-like Behavior in Drosophila melanogaster: The Role of α7 & β2 Nicotinic Acetylcholine Receptor Subunits in Sensory Valence and Cellular Stress [0.03%]
尼古丁毒性及其成瘾行为的机制：α7和β2烟碱乙酰胆碱受体亚基在感觉阀值和细胞压力中的作用
Titilayomi Ayomide Otenaike,Oluwabukola Mary Farodoye,Joao Batista Rocha Texeira et al.
Titilayomi Ayomide Otenaike et al.
Nicotine addiction and toxicity are complex neurobiological conditions conventionally treated as separable phenomena, yet increasing evidence suggests they share overlapping neurobiological effects. Nicotinic acetylcholine receptors (nAChRs...
PM2.5 exposure exacerbates cerebral infarction via HPG axis downregulation and pituitary lipid metabolism dysregulation in mice [0.03%]
PM2.5暴露通过下调下丘脑-垂体-性腺轴和扰乱垂体脂质代谢加重小鼠脑梗死
Xin Lv,Guanhui Pei,Lijuan Liu et al.
Xin Lv et al.
Epidemiological studies have consistently associated ambient fine particulate matter (PM2.5) with poor post-stroke prognosis. Growing evidence identifies endocrine dysregulation as a critical driver of stroke severity. Nevertheless, the inf...
Effects of gastrodin on methamphetamine-induced apoptosis in rat hippocampus via the NF-κB/NLRP3/Caspase-8 signaling pathway [0.03%]
天麻素通过NF-κB/NLRP3/Caspase-8信号通路干预麻精所致大鼠海马细胞凋亡的作用研究
Zhang Yuan,Liu Pengliang,Dong Wenjuan et al.
Zhang Yuan et al.
Objectives: This study aimed to elucidate the correlation between changes in key factors of the NF-κB/NLRP3/Caspase-8 signaling pathway and neuronal apoptosis in the hippocampus resulting form methamphetamine (METH) addi...
Gestational and lactational exposure to glyphosate and a glyphosate-based herbicide causes sex-dependent effects on neurodevelopment and monoaminergic markers in rats [0.03%]
glyphosate及草甘膦除草剂的妊娠和哺乳暴露引起大鼠神经发育和单胺类标记物性别依赖性效应
Isela Hernández-Plata,Jair Santiago-Salazar,María Soledad Mendoza-Trejo et al.
Isela Hernández-Plata et al.
Glyphosate (Glyph) exposure during the gestational and lactational periods have been linked to neurodevelopmental alterations in humans and animal models, and it has been proposed to induce autistic-like traits in rodents. This study evalua...
Chronic bisphenol A exposure impairs cognitive function in male mice associated with NLRP3 inflammasome-driven pyroptosis and gut microbiota dysbiosis along the microbiota-gut-brain axis [0.03%]
慢性双酚A暴露通过微生物群-肠道-脑轴介导的NLRP3炎性小体驱动的焦亡和肠道菌群紊乱损害雄性小鼠认知功能
Zhongwei Tang,Junjie Yang,Xin Guo et al.
Zhongwei Tang et al.
The microbiota-gut-brain axis (MGBA) is a critical bidirectional communication system governing cognitive function and intestinal homeostasis. Despite growing evidence linking environmental chemicals to neurological disorders, the mechanism...
The role of mTORC2 in the in vitro neurotoxicity of Parkinsonian mimetics 6-OHDA and MPP [0.03%]
mTORC2在帕金森病拟似毒物6-HD和MPP+的体外神经毒性作用中的角色研究
Marija Jeremic,Maja Jovanovic-Tucovic,Tamara Martinovic et al.
Marija Jeremic et al.
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of mTOR...
Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer's disease [0.03%]
空气污染与阿尔茨海默病易感脑区皮层厚度变化模式相关
Lauren E Salminen,Xinhui Wang,Andrew J Petkus et al.
Lauren E Salminen et al.
Introduction: Ambient air pollution increases Alzheimer's disease (AD) risk, yet exposure associations with cortical thickness (CTh) in AD-vulnerable brain regions is unclear. Here we examined the associations between PM2...
Molecular mechanism of dopaminergic neuron injury induced by PAHs: Regulation of AhR-RORα/Nrf2 axis and α-syn O-GlcNAc modification [0.03%]
PAHs诱导多巴胺能神经元损伤的分子机制：AhR-RORα/Nrf2轴调节和α-突触核蛋白O-GlcNAc修饰调控
Yitian Gao,Chenyang Duan,Xiaohan Zheng et al.
Yitian Gao et al.
Parkinson's disease (PD) ranks second among prevalent global neurodegenerative disorders. It is pathologically characterized by gradual degeneration of midbrain substantia nigra compacta dopaminergic neurons and excessive α-synuclein (α-s...
Bioinformatics and Experimental Insights into the Relationship between Ferroptosis and Fluoride-Induced Neurotoxicity [0.03%]
生物信息学和实验揭示铁死亡介导的氟阴离子致神经毒性机制及其防治新策略
Qinyang Qin,Yuhui Du,Xinying Wang et al.
Qinyang Qin et al.
Although fluoride is known to cause neurological impairment, the underlying molecular mechanisms remain unclear. Given that ferroptosis may contribute to neurotoxicity, we explored whether fluoride induces neuronal ferroptosis and sought to...
Human blood-derived neural progenitor cells as a platform for developmental neurotoxicity of micro- and nanoplastics [0.03%]
人血源性神经祖细胞作为微塑料和纳米塑料发育神经毒性研究的平台
Kinga Vojnits,Jad Kaj,Kelly Rees et al.
Kinga Vojnits et al.
Micro- and nanoplastics (MNPs) are increasingly detected in human tissues, including the placenta and brain, raising concerns about their potential impact on early neurodevelopment. However, mechanistic insight is limited by the lack of hum...