Exploratory transcriptomic and network-based analysis of methylmercury exposure in human neuronal developmental models using GEO datasets and toxicogenomic resources [0.03%]
基于GEO数据集和毒转组资源的人类神经发育模型甲基汞暴露的探索性转录组和网络分析
Danna Gomez-Caballero,Jesus Olivero-Verbel
Danna Gomez-Caballero
Background: Methylmercury (MeHg) is a well-recognized environmental neurotoxicant with a marked impact on neurodevelopment. However, studies integrating stage-specific transcriptomic responses in human neuronal developmen...
Association between metal exposure and depressive symptoms: The mediating role of fatty acids [0.03%]
金属暴露与抑郁症状的关系：脂肪酸的中介作用
Yun Qiu,Yong-Xiang Tang,Zengliang Ruan et al.
Yun Qiu et al.
Background: Previous studies have shown that metal exposure has been linked to depressive symptoms, with fatty acids potentially playing a role in this connection. Moreover, evidence on broader metal mixtures remains limi...
Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment [0.03%]
通过整合涵盖神经发育关键细胞事件的新方法（NAM）数据优先对发育性神经毒性的化学品进行分类
Laura A Hall,Jui-Hua Hsieh,Skylar W Marvel et al.
Laura A Hall et al.
Thousands of chemicals have not been assessed for developmental neurotoxicity (DNT) despite potential human exposure, prompting efforts to screen chemicals for possible DNT hazard using in vitro approaches. Ninety-five chemicals were screen...
Radon-related increases in depressive symptoms are explained by amygdala morphology and external locus of control [0.03%]
与杏仁核形态学和外在控制源有关的氡相关的抑郁症状增加
Grace E Parolek,Monica N Clarke-Smith,Saige C Rasmussen et al.
Grace E Parolek et al.
Objective: Environmental toxins have been linked to depressive symptoms, potentially via brain morphology and cognition. In particular, the amygdala acts as an affective hub and may be especially sensitive to environmenta...
Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model [0.03%]
急性木烟暴露与加速卵巢衰竭小鼠模型海马转录本反应相关的研究
Sydnee J Yazzie,Mijung Oh,Eunju Lim et al.
Sydnee J Yazzie et al.
Background: Wildfire events are increasing in frequency and intensity, and aging individuals demonstrate heightened biological susceptibility to air pollution exposures including increased risk of neurological sequelae. D...
The association between exposure to flame retardants and cognitive function in the elderly: Unveiling potential intervention strategies [0.03%]
阻燃剂暴露与老年人认知功能障碍的关联：探索潜在干预策略
Yu Liu,Shiqi Luo,Jianjun Liu et al.
Yu Liu et al.
Background: Human beings have been widely exposed to various types of flame retardants, but little is known about their effects on cognitive function in the elderly. ...
Cameron P Hamson,Morgan L Atkinson,Troy A Roepke
Cameron P Hamson
As the implementation of 'sex as a biological variable' policies have been enacted across the world, the study of sex differences or comparisons across the sexes has steadily increased. In the field of neurotoxicology, the study of sex-depe...
Best Practices in Neurotoxicology Research Must Account for Spontaneous Brain Malformations in Rodent Models [0.03%]
啮齿类模型中自发性脑畸形须纳入神经毒理学研究的最佳实践范围内考虑
Justin T Popp,Raddy L Ramos
Justin T Popp
Spontaneous neocortical and cerebellar heterotopia are present in rat and mouse strains commonly used in neurotoxicology research. These malformations reflect neuronal migration defects during neocortical and cerebellar development that are...
Comparing effects of gaseous vs. particulate components of traffic-related air pollution on Alzheimer's disease biomarkers in a genetically susceptible rat model [0.03%]
比较气态和颗粒态交通相关空气污染成分对遗传易感性大鼠模型阿尔茨海默病生物标志物的影响
Nathifa Nasim,Mei-Yun Cheng,Heui Hye Park et al.
Nathifa Nasim et al.
Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer's disease (AD) and AD-related dementia (ADRD), and while experimental animal studies corroborate this association, most utilized exposure paradigm...
Simulated wildfire smoke particulate matter elicits STING-dependent astrocyte-mediated inflammatory signaling and neurotoxicity [0.03%]
模拟野火烟雾颗粒物诱发STING依赖性的星形胶质细胞介导的炎症信号和神经毒性
Adam J Schuller,Abigail M Bibb,Megan R Hager et al.
Adam J Schuller et al.
Changing global wildfire landscapes necessitate exploration of the effects of exposure to wildfire smoke on health and disease. Exposure to this toxicant is not only associated with acute cardiopulmonary dysfunction, but is increasingly rec...