Mechanisms Underlying Perfluorooctanoic Acid-Induced Neuronal Loss and Cognitive Deficits: Disruption of Mitochondrial Dynamics, Impaired Mitophagy, and Blood-Brain Barrier Dysfunction [0.03%]
全氟辛酸诱导的神经元损失和认知缺陷的机制：线粒体动力学受干扰、自噬溶酶体受损以及血脑屏障功能障碍
Vikrant Rahi,Ravinder K Kaundal
Vikrant Rahi
Perfluorooctanoic acid (PFOA), a persistent member of the Per- and polyfluoroalkyl substances (PFAS), is widely detected in the environment and human populations and has recently been increasingly associated with neurotoxicity; however, its...
Aluminum and Alzheimer's disease in the 21st century: An umbrella review of evidence and controversies [0.03%]
21世纪的铝和阿尔茨海默病：证据与争议综述
Jose L Domingo,Maria Teresa Colomina
Jose L Domingo
The potential role of aluminum (Al) in the onset and progression of Alzheimer disease (AD) remains among the most enduring and divisive controversies in environmental neurotoxicology. Although numerous narrative reviews, systematic reviews,...
The mechanism by which long-term exposure to TDCIPP promotes cognitive impairment in 3 ×Tg-AD mice: Insights from multi-omics studies [0.03%]
TDCIPP长期暴露致3×Tg-AD小鼠认知障碍的机制研究：多组学视角
Tingting Yang,Yu Liu,Ruoxuan Liang et al.
Tingting Yang et al.
Tri(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate ester that has the potential to adversely affect human health. Although previous studies have closely associated TDCIPP with cognitive impairment, the underlyi...
Subchronic benzo[a]pyrene exposure disrupts APOE4-regulated lipid metabolism to induce Tau hyperphosphorylation and cognitive deficits [0.03%]
苯并[a]芘暴露通过破坏载脂蛋白E4调节的脂质代谢诱导Tau过度磷酸化及认知缺陷
Wenyu Wang,Xinyu Zhu,Shuangxi Geng et al.
Wenyu Wang et al.
Background: Benzo[a]pyrene (B[a]P) is both a carcinogen and a potent neurotoxic pollutant. Despite growing evidence linking B[a]P to neurological dysfunction, the responsible mechanisms have not been elucidated. ...
Eleanna M Melcher,Amy J H Kind
Eleanna M Melcher
Toxicology and neurotoxicology have contributed tremendously to furthering scientific understandings of the harmful toxicants in our natural and built environments. In tandem with rigorous scientific findings, both disciplines have interven...
Manganese overload as a previously underappreciated trigger of cellular senescence: Unraveling mechanisms and therapeutic rescue by the senolytic quercetin [0.03%]
锰过载诱发衰老的机制及利用槲皮素清除衰老细胞的研究
Zehua Tao,Chongyang Guo,Siyu Xu et al.
Zehua Tao et al.
Manganese (Mn) is an essential trace element, but excessive Mn exposure is associated with neurotoxicity and aging-related dysfunction. Whether Mn overload promotes cellular senescence and the mechanisms involved remain insufficiently defin...
Detection of seizurogenic compounds in human and rat neurons in vitro: a multi-laboratory, multi-model assessment [0.03%]
人和大鼠神经元体外模型检测促癫痫化合物的多中心、多方法评估研究
Ruth Roberts,Ksenia Blinova,Coby Carlson et al.
Ruth Roberts et al.
Seizure liability remains a key risk for drug development and following chemical exposure. Advances in induced pluripotent stem cell (iPSC) biology and in vitro detection methodologies such as multielectrode array (MEA) offer an opportunity...
Copper induces depressive-like behavior through neuronal lipid accumulation mediated by Lipin-1 [0.03%]
铜通过Lipin-1介导的神经元脂质积累诱导类似抑郁的行为
Qingqi Li,Xueer Cao,Hongrong Wu et al.
Qingqi Li et al.
Copper (Cu) is an essential trace element that plays a critical role in numerous biological processes. However, excessive Cu exposure has been associated with a range of adverse effects, including metabolic disturbances and neurological dys...
Integrating exposure across the lifespan: Early life exposures as risk factors for Parkinson's disease [0.03%]
生命周期全程暴露整合：生命早期暴露作为帕金森病的风险因素
Allie M Smith,Briana R De Miranda,Alison I Bernstein
Allie M Smith
Environmental risk factors and gene-environment interactions play critical roles in Parkinson's disease (PD) pathogenesis, and approximately two-thirds of the phenotypic variance of sporadic PD appears to be attributed to non-heritable fact...
Pyrethrin II impairs mitochondrial potential through ROS and MAPK pathways in HT‑22 cells [0.03%]
除虫菊素II通过ROS和MAPK途径损害HT-22细胞的线粒体电位
Jiaojiao Gao,Xinbi Zhang,Qie Mu et al.
Jiaojiao Gao et al.
Objective: Pyrethrin II, a key active monomer of natural pyrethrins, is widely used in household insecticides. This study investigated whether Pyrethrin II induces hippocampal neuronal injury through ROS overproduction an...