Gestational and lactational exposure to glyphosate and a glyphosate-based herbicide causes sex-dependent effects on neurodevelopment and monoaminergic markers in rats [0.03%]
glyphosate及草甘膦除草剂的妊娠和哺乳暴露引起大鼠神经发育和单胺类标记物性别依赖性效应
Isela Hernández-Plata,Jair Santiago-Salazar,María Soledad Mendoza-Trejo et al.
Isela Hernández-Plata et al.
Glyphosate (Glyph) exposure during the gestational and lactational periods have been linked to neurodevelopmental alterations in humans and animal models, and it has been proposed to induce autistic-like traits in rodents. This study evalua...
Chronic bisphenol A exposure impairs cognitive function in male mice associated with NLRP3 inflammasome-driven pyroptosis and gut microbiota dysbiosis along the microbiota-gut-brain axis [0.03%]
慢性双酚A暴露通过微生物群-肠道-脑轴介导的NLRP3炎性小体驱动的焦亡和肠道菌群紊乱损害雄性小鼠认知功能
Zhongwei Tang,Junjie Yang,Xin Guo et al.
Zhongwei Tang et al.
The microbiota-gut-brain axis (MGBA) is a critical bidirectional communication system governing cognitive function and intestinal homeostasis. Despite growing evidence linking environmental chemicals to neurological disorders, the mechanism...
The role of mTORC2 in the in vitro neurotoxicity of Parkinsonian mimetics 6-OHDA and MPP [0.03%]
mTORC2在帕金森病拟似毒物6-HD和MPP+的体外神经毒性作用中的角色研究
Marija Jeremic,Maja Jovanovic-Tucovic,Tamara Martinovic et al.
Marija Jeremic et al.
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of mTOR...
Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer's disease [0.03%]
空气污染与阿尔茨海默病易感脑区皮层厚度变化模式相关
Lauren E Salminen,Xinhui Wang,Andrew J Petkus et al.
Lauren E Salminen et al.
Introduction: Ambient air pollution increases Alzheimer's disease (AD) risk, yet exposure associations with cortical thickness (CTh) in AD-vulnerable brain regions is unclear. Here we examined the associations between PM2...
Molecular mechanism of dopaminergic neuron injury induced by PAHs: Regulation of AhR-RORα/Nrf2 axis and α-syn O-GlcNAc modification [0.03%]
PAHs诱导多巴胺能神经元损伤的分子机制：AhR-RORα/Nrf2轴调节和α-突触核蛋白O-GlcNAc修饰调控
Yitian Gao,Chenyang Duan,Xiaohan Zheng et al.
Yitian Gao et al.
Parkinson's disease (PD) ranks second among prevalent global neurodegenerative disorders. It is pathologically characterized by gradual degeneration of midbrain substantia nigra compacta dopaminergic neurons and excessive α-synuclein (α-s...
Bioinformatics and Experimental Insights into the Relationship between Ferroptosis and Fluoride-Induced Neurotoxicity [0.03%]
生物信息学和实验揭示铁死亡介导的氟阴离子致神经毒性机制及其防治新策略
Qinyang Qin,Yuhui Du,Xinying Wang et al.
Qinyang Qin et al.
Although fluoride is known to cause neurological impairment, the underlying molecular mechanisms remain unclear. Given that ferroptosis may contribute to neurotoxicity, we explored whether fluoride induces neuronal ferroptosis and sought to...
Human blood-derived neural progenitor cells as a platform for developmental neurotoxicity of micro- and nanoplastics [0.03%]
人血源性神经祖细胞作为微塑料和纳米塑料发育神经毒性研究的平台
Kinga Vojnits,Jad Kaj,Kelly Rees et al.
Kinga Vojnits et al.
Micro- and nanoplastics (MNPs) are increasingly detected in human tissues, including the placenta and brain, raising concerns about their potential impact on early neurodevelopment. However, mechanistic insight is limited by the lack of hum...
Reduced hepcidin expression leads to iron accumulation in the substantia nigra of rotenone-induced rat model of Parkinson's disease [0.03%]
他莫西林表达降低导致罗tenone诱导的帕金森病大鼠模型黑质铁沉积增多
Feimi Li,Christopher Qian,Qian Guo et al.
Feimi Li et al.
Despite years of research, it is still unclear why iron accumulates in the substantia nigra (SN) of Parkinson's disease (PD) animal models and PD patients. To address this, we investigated the changes in serum iron, iron content, transferri...
Combined exposure to 6PPD and 6PPD-Q induced neurotoxic responses in zebrafish and SH-SY5Y cells: evidence from neurotransmitter disruption, oxidative damage, and apoptosis [0.03%]
6PPD及其代谢物6PPD-Q联合暴露诱导斑马鱼和SH-SY5Y细胞神经毒性响应：来自神经递质紊乱、氧化损伤和凋亡的证据
Ziwei Wang,Shutao Wang,Wanlun Li et al.
Ziwei Wang et al.
The rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its quinone derivative (6PPD-Q) are coexisting environmental contaminants with documented neurobehavioral effects. However, the neurotoxic consequences ari...
Mitochondria-driven oxidative stress mediates cyproconazole-induced genotoxicity, caspase-dependent apoptosis, and glial neuroinflammation in human neuronal and glial cell lines [0.03%]
线粒体驱动的氧化应激介导了氮氯苯唑诱导的人神经和胶质细胞系中的遗传毒性、半胱天冬酶依赖性凋亡和胶质神经炎症
Mnassri Asma,Chaabani Hanen,Abderrazk Fatma et al.
Mnassri Asma et al.
Cyproconazole (CYPRO), a triazole fungicide widely used in agriculture, poses potential risks to the central nervous system, yet its neurotoxic mechanisms remain poorly characterized. This study provides the first integrative mechanistic in...