Protective effects of sodium benzoate against toluene-induced reward enhancement, behavioral disturbances, and impaired synaptic plasticity in mice [0.03%]
苯甲酸钠对托伦烃诱导的小鼠奖赏增强、行为异常和突触可塑性损伤的保护作用
Chung-Pin Hsieh,Mei-Yi Lee,Chia-Yu Lin et al.
Chung-Pin Hsieh et al.
Toluene is one of the most commonly abused solvents. Inhibition of N-methyl-D-aspartate receptor (NMDAR) has been linked to the rewarding and behavioral effects of toluene. One of the avenues to enhance NMDAR function is to increase the lev...
Longitudinal changes in pallidal index and their associations with urinary manganese and CaNa₂EDTA chelation [0.03%]
苍白球指标变化及其与尿锰和CaNa₂EDTA螯合水平的关系纵向变化
Tuğba Akkale,Nuriye Kayalı Şendur,Süleyman Filiz et al.
Tuğba Akkale et al.
Objectives: In this study, the evaluation of the change in pallidal index (PI) (ΔPI) between baseline and follow-up magnetic resonance imaging; the examination of the relationship between ΔPI and spot urine manganese (M...
Taurine Modulates Gut Microbiota and Attenuates Inflammation in a Rotenone-Induced Mouse Model of Parkinson's disease [0.03%]
牛磺酸调节肠道微生物群并减轻罗滕酮诱导的帕金森病小鼠模型中的炎症
Yunbo Zhu,Shuo Wang,Shuang Zhao et al.
Yunbo Zhu et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder in which gut microbiota play a critical role in pathogenesis through the gut-brain axis. Taurine has been reported to exhibit neuroprotective properties. In this study, we e...
Beta-caryophyllene restores liver-brain axis integrity in thioacetamide-induced hepatic encephalopathy: Behavioral and molecular insights [0.03%]
β-石竹烯恢复噻乙酰胺诱导的肝性脑病中的肝脑轴完整性：行为和分子见解
Samet Tekin,Merve Bolat,İsmail Bolat et al.
Samet Tekin et al.
Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of liver dysfunction, driven by hyperammonemia, oxidative stress, neuroinflammation, apoptosis, and endoplasmic reticulum (ER) stress, which disrupt the hepato-encephalic...
From correlation to causation: Integrating cohorts with experimental studies in mixture toxicology [0.03%]
从相关性到因果关系：在群体研究中进行实验以开展复合毒物学研究
Ahmed Elagali,Joëlle Rüegg,Nicolò Caporale et al.
Ahmed Elagali et al.
Harmful chemical mixtures are pervasive in the environment, yet traditional epidemiological designs face major challenges in establishing causal links between individual chemicals or mixture exposures and health outcomes. These challenges a...
Neuroprotection via IGF-1 Neuronal Signaling Activation by Melatonin and Edaravone Synergy in Methylmercury-Induced ALS-like Neurotoxicity: Comprehensive Analysis of Brain Regions, Spinal Cord, CSF, and Blood Plasma [0.03%]
褪黑素和埃多司坦协同激活IGF-1神经信号通路保护甲基汞引起的ALS样神经毒性的作用：对脑区、脊髓、脑脊液和血浆的全面分析
Gurudev Singh Raina,Sidharth Mehan,Ghanshyam Das Gupta
Gurudev Singh Raina
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron degeneration, oxidative stress, neuroinflammation, and neurotransmitter imbalances. This study explored the neuroprotective potenti...
The long-acting anticoagulant rodenticide brodifacoum induces neuropathology in adult New Zealand White rabbits and is reduced by the bile sequestrant cholestyramine [0.03%]
长效抗凝灭鼠药华法林诱导成年新西兰兔神经病理学改变，并可通过胆汁结合剂降胆固醇树脂缓解该损伤
Intakhar Ahmad,Jacqueline Rocha,Zachary McDonald et al.
Intakhar Ahmad et al.
Previous studies showed that exposure to long-acting anticoagulant rodenticides (LAARs) can induce neuropathology in adult rats. In the current study we tested if the potent LAAR brodifacoum similarly promoted neuropathology in adult rabbit...
The Impact of Military Occupational Combustion Smoke Inhalation on Neuroinflammation and Brain Health [0.03%]
军事职业燃烧烟雾吸入对神经炎症和脑健康的影响
Anthony R White
Anthony R White
Airborne combustion emissions from military burn pits, wildfires, and urban/industrial sources are increasingly recognized as a component of the neurotoxic exposome, with potential consequences extending beyond cardiopulmonary disease to br...
Gallic and ascorbic acids either alone or combined contribute to ameliorating lead-induced cerebral neurotoxicity in rats: A histological and immunohistochemical study [0.03%]
单一或联合使用棓酸和抗坏血酸可减轻大鼠铅诱导的脑神经毒性：组织学和免疫组化研究
Lamiaa M Shawky,Ahmed A Morsi,Nermine Beshara et al.
Lamiaa M Shawky et al.
Lead (Pb) toxicity is a great community health problem. Brain is the primary target organ of Pb intoxication. Ascorbic acid (AA) and Gallic acid (GA) have proven to show potential anti‑inflammatory and antioxidant properties during heavy m...
Prolonged duration induces divergent transcriptomic responses to manganese, distinct from concentration effects, in an SH-SY5Y neurotoxicity model [0.03%]
暴露时间对SH-SY5Y神经毒性模型中锰诱导的转录组响应的影响大于浓度效应
Xueqi Tang,Priyanka Baloni,Michael Aschner et al.
Xueqi Tang et al.
Understanding manganese (Mn) neurotoxicity requires experimental models that realistically reflect human exposure scenarios. A key limitation of current in vitro paradigms is the reliance on acute, high-concentration exposures, which may no...