Danmeng Lily Li,Joanne Ryan,Allison M Hodge et al.
Danmeng Lily Li et al.
Epigenetic alterations are an important shared hallmark of ageing and cancer. The development of epigenetic markers of ageing using blood DNA methylation data has been an active area of research. These markers have been used to assess disea...
Single-cell aging clocks: A precision tool for dissecting and targeting the aging process [0.03%]
单细胞衰老时钟：解析和靶向衰老过程的精密工具
Yuduo Hao,Sijia Xie,Yijie Wei et al.
Yuduo Hao et al.
Biological age, an indicator of an individual's health status, was initially measured using bulk tissue aging clocks. However, by averaging molecular signals across thousands of cells, these tools mask the cellular heterogeneity that charac...
Jarrod J Kennedy,Patrick Bertolino,Sophie Lucic Fisher et al.
Jarrod J Kennedy et al.
Ageing is associated with a dysregulated immune system that contributes to vulnerability in older adults to infection, malignancies, autoimmune diseases, and inflammatory disorders. This immune dysfunction can be categorised into two proces...
Targeting the Nrf2/HO-1 aixs: a therapeutic strategy against regulated cell death in Alzheimer's disease [0.03%]
靶向Nrf2/HO-1轴：阿尔茨海默病调节性细胞死亡的治疗策略
Zhiji Wang,Wenxin Feng,Xiaohua Li et al.
Zhiji Wang et al.
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaque deposition, neurofibrillary tangles of hyperphosphorylated tau protein, chronic neuroinflammation, and dysregulatio...
Fanconi anaemia as a human model of accelerated epigenetic and immune ageing [0.03%]
范可尼贫血作为人类表观遗传和免疫老化的加速模型
Eunike Velleuer,Carsten Carlberg
Eunike Velleuer
Fanconi anaemia (FA) is a DNA-repair disorder that compresses multiple hallmarks of ageing into childhood and early adulthood. Persistent genomic instability in FA precipitates oxidative stress, inflammatory remodelling, and metabolic repro...
Huimin Liu,Haiqing Tang,Shanshan Pang
Huimin Liu
Lysosomes are responsible for clearing cellular waste and facilitating material recycling, thus playing a crucial role in maintaining cellular homeostasis and even in resisting the development of various diseases. Lysosomes are highly dynam...
Oligodendrocytes at the Crossroads: Central Players and Interactive Partners in White Matter Aging [0.03%]
少突胶质细胞在白质老化中的中心作用及其与其他细胞的相互作用
Xinxin Zhang,Peiyao Yu,Yicheng Chen et al.
Xinxin Zhang et al.
White matter degeneration in aging drives cognitive and motor decline. Oligodendrocytes (OLs) and their precursors are central to this process. Their intrinsic aging, marked by differentiation failure, metabolic and mitochondrial deficits, ...
Dan Zhong,Benjamin Fernández-García,Priyanka Gokulnath et al.
Dan Zhong et al.
Cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis and myocardial infarction, remain the leading cause of morbidity and mortality worldwide. Aging is a predominant risk factor for CVD. Cardiovascular agin...
The m⁶A Epitranscriptome: A Regulatory Nexus Linking Cellular Senescence and Oncogenesis [0.03%]
m６A表观转录组：连接细胞衰老和肿瘤发生的调控中心
Yao Xu,Xin Zhou,Xiaoling Su et al.
Yao Xu et al.
N⁶-methyladenosine (m⁶A) orchestrates RNA fate decisions through a dynamic interplay of writers, erasers, and readers, modulating splicing, stability, and translation. This review unveils how m⁶A fine-tunes senescence-associated pathways...
exBAClock: a comprehensive database of published clocks for age quantification and age-related diseases [0.03%]
exBAClock：用于年龄量化和衰老相关疾病的已发表clock的综合数据库
Anastasiya Kobelyatskaya,Anastasiya Novoselova,Ksenia Bylinskaya et al.
Anastasiya Kobelyatskaya et al.
Biological age, as opposed to chronological age, quantifies the body's functional state and rate of aging. Despite the absence of a universal formula for its determination, panels of biomarkers that change consistently with age are used to ...