The Physical Senotype in cellular senescence: Mechanical and physical strategies for senotherapy [0.03%]
细胞衰老中的物理表型：用于衰老治疗的机械和物理策略
Bingjie Wang,Xiangqing Qi,Johnny Huard et al.
Bingjie Wang et al.
Cellular senescence is traditionally described through durable cell-cycle arrest, DNA-damage signaling, metabolic remodeling, mitochondrial and lysosomal dysfunction, and acquisition of a senescence-associated secretory phenotype (SASP). Ho...
Cellular senescence at the bidirectional interface between ageing and coronary artery disease [0.03%]
细胞衰老在双向连接衰老和冠状动脉疾病之间的作用
Xinxin Li,Hanwen Zhang,Mengjia Chen et al.
Xinxin Li et al.
Coronary artery disease (CAD) is a major global cause of morbidity and mortality, and population ageing is reshaping its clinical phenotype, disease trajectory, and therapeutic complexity. Chronological age alone cannot explain the heteroge...
Beyond the barrier: Physiological determinants of nanoformulation availability in the aging brain [0.03%]
屏障之外：老化大脑中纳米药物制剂生理有效性的决定因素
Ruei-Dun Teng,Jui-Ming Sun,Ting-Lin Yen et al.
Ruei-Dun Teng et al.
Nanomedicine has revolutionized brain-targeted therapeutics; however, most design paradigms remain centered on overcoming the blood-brain barrier while overlooking the dynamic physiological milieu that governs nanoparticle fate after entry....
The role of ageing-specific PTM remodeling in myocardial ischemia-reperfusion injury [0.03%]
心肌缺血再灌注损伤中与衰老有关的PTM重编程的作用
Qian Liu,Qiuyan Luo,Shuqin Zhong et al.
Qian Liu et al.
Myocardial ischemia-reperfusion injury (MIRI) in patients with acute myocardial infarction (AMI) after thrombolytic therapy or percutaneous coronary intervention is one of the diseases with threatening health and increasing mortality. Despi...
Olga I Kechko,Alexey A Moskalev,Claudio Franceschi et al.
Olga I Kechko et al.
Inflammaging, the chronic subclinical systemic inflammation accompanying aging, represents a critical pathogenetic mechanism underlying age-related neurodegenerative diseases. While amyloid beta (Aβ) peptides are established contributors t...
Gating of Somatosensory Neural Oscillations Across the Lifespan: A Narrative Review [0.03%]
一生中体感神经振荡的门控：综述文章
Mahak Virlley,Rachel K Spooner,Tony W Wilson et al.
Mahak Virlley et al.
Healthy and pathological aging are associated with progressive changes in cortical inhibition, yet the underlying neural mechanisms remain incompletely understood. Somatosensory gating (SG), the brain's suppression of redundant tactile inpu...
From Primates to People: Mapping Host-Microbiome-Health Relationships in Aging [0.03%]
从灵长类到人类：绘制宿主微生态健康关系图谱与衰老的关系
Angélica Olmo-Fontánez,Kelly R Reveles,Riti Sharan et al.
Angélica Olmo-Fontánez et al.
The human microbiome profoundly influences host physiology, metabolism, and immune function. A balanced microbial ecosystem supports immune homeostasis and health, whereas dysbiosis contributes to diverse diseases, including metabolic, auto...
The Human Retina in Alzheimer's Disease: Pathology, Mechanisms, and Biomarkers [0.03%]
阿尔茨海默病的人眼视网膜病理、机制和生物标志物研究
Luis Pérez de Sevilla,Sriparna Majumdar,Brandy Recio
Luis Pérez de Sevilla
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and synaptic dysfunction that begins decades before clinical symptoms emerge. While AD research has traditionally focused on the brain, increasing evidence suggests ...
Complosome as a key modulator of cellular senescence, aging and age-related diseases [0.03%]
complosome在细胞衰老、衰老及其相关疾病中的关键调节作用
Naheemat Modupeola Gold,Michael Ngozi Okeke,Samuel Ewhea Ajoronor et al.
Naheemat Modupeola Gold et al.
Aging is characterized by progressive physiological decline and accumulation of senescent cells that drive chronic "inflammaging" through the senescence-associated secretory phenotype (SASP). The complement system, traditionally viewed as a...
The effects of multi-session resistance exercise on cognitive function in healthy adults: A systematic research review and meta-analysis [0.03%]
多次抗阻运动对健康成年人认知功能影响的系统性研究综述和元分析
George Molloy,Yasina Somani,Jean-Francois Delvenne et al.
George Molloy et al.
Objectives: Cognitive decline is a growing global concern, and lifestyle-based interventions are increasingly recognised as promising preventive strategies. This review synthesises evidence on the cognitive effects of mul...