Sleep deterioration as a systems-level readout of aging biology: integrating metabolic, inflammatory and circadian mechanisms [0.03%]
睡眠退化作为衰老生物学的系统层面读数：整合代谢、炎症和昼夜机制
Antonio Fernando Murillo-Cancho,David Lozano-Paniagua,María Del Mar Martín-Latorre et al.
Antonio Fernando Murillo-Cancho et al.
Sleep architecture and continuity deteriorate markedly with aging, yet these changes are frequently approached as isolated sleep disorders rather than as manifestations of systemic biological dysregulation. Accumulating evidence indicates t...
Growth differentiation factor-15 as a clinical biomarker of frailty, sarcopenia and functional decline: A systematic literature review [0.03%]
生长分化因子-15作为虚弱、肌少症和功能下降的临床生物标志物的系统文献回顾
Ainsley Ryan Yan Bin Lee,S Nachammai Vidhya,Anjin Hong et al.
Ainsley Ryan Yan Bin Lee et al.
Background: With an aging population globally, prevention of frailty and sarcopenia will become a public health priority. Growth Differentiation Factor-15 (GDF-15), a stress-responsive cytokine of the TGF-β superfamily, ...
Resilience-Based Longevity Medicine: A Multiscale and Dynamic Integrative Framework [0.03%]
基于韧性的长寿医学：多层次和动态综合框架
Mathias Schlögl,Vincenza Frisardi,Luigi Marano et al.
Mathias Schlögl et al.
Population ageing has widened the gap between lifespan and healthspan, with frailty and functional dependence increasingly shaping late-life outcomes. Yet trajectories in older age remain highly heterogeneous, suggesting that vulnerability ...
Proteostasis, disease and the ageing neuron: Compartmental complexity in non-renewing cells [0.03%]
蛋白质稳态、疾病与衰老神经元：非更新细胞中的区室复杂性
Rosemary A Coleman,Michaela E Johnson,Anna Konopka et al.
Rosemary A Coleman et al.
Proteostasis, the maintenance of protein homeostasis, is a critical cellular process for neuronal health that declines with age, contributing to neurodegenerative disease. This review examines the molecular architecture of the proteostasis ...
Epidemiological trends and cross-country inequalities in the global burden of Alzheimer's disease and other dementias in postmenopausal women from 1990 to 2021 [0.03%]
1990年至2021年绝经后女性阿尔茨海默病和其他痴呆症的全球疾病负担流行趋势及国家间差异
Junmiao Ge,Junli Ge,Mingdong Bao et al.
Junmiao Ge et al.
Objective: To evaluate the trends, cross-country inequalities, and risk factors associated with Alzheimer's disease and other dementias (ADOD) in postmenopausal women globally, and project the disease burden to 2050. ...
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine [0.03%]
帕金森病单基因病因研究进展：对患者分层和个体化治疗的影响
Sakeena Asmi,Anand Krishnan,Sneha Mary Alexander et al.
Sakeena Asmi et al.
Parkinson's disease (PD) is a complex neurodegenerative disorder with both genetic and environmental contributions. Over the past two and a half decades, advances in genetics, genomics and molecular biology have uncovered several monogenic ...
Advocating gut-retina connection and microbiota mediated pathways in management of age-related macular degeneration: Preclinical to clinical perspective [0.03%]
倡导肠-视网膜连接及肠道微生态介导的途径在年龄相关性黄斑变性疾病管理中的作用：从基础到临床的观点
Pramod V Waghmare,Kaustubh Ajit Kolekar,Bushra Bashir et al.
Pramod V Waghmare et al.
Age-related macular degeneration (ARMD) is the primary manifestation of permanent vision loss internationally. Different factors that contribute to ARMD involve ageing, genetic predisposition, oxidative stress, immunological imbalances, abe...
Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases [0.03%]
神经退行性疾病中的胰岛素抵抗和SIRT1失调
Anery Shah,Gaurav Doshi
Anery Shah
Metabolic diseases such as Type 2 Diabetes, obesity, and metabolic syndrome are increasing worldwide in parallel with neurodegenerative disorders, yet a unifying biological framework linking systemic metabolic dysfunction to progressive neu...
The Sweet Gatekeeper: Mucin-Type O-Glycans in Brain Endothelial Glycocalyx and Aging [0.03%]
甜门卫：脑内皮糖萼寡糖蛋白O-连接型糖基化在衰老中的作用
Duan Lu Hou,Yun-Cheng Wu,Eng King Tan et al.
Duan Lu Hou et al.
The blood-brain barrier (BBB) is crucial for brain homeostasis, and its dysfunction is associated with aging and neurodegenerative diseases. A recent seminal study by Shi et al. (2025) published in Nature illuminates a previously underappre...
Kartini I Vosshage,James R Swift,Ayoung Kim et al.
Kartini I Vosshage et al.
The growing ageing population presents significant challenges for healthcare systems, particularly in monitoring age-related physiological decline. Ageing is a complex, multifactorial process that manifests without specific symptoms and is ...