Cerebral glymphatic system: structure, regulation, ageing, and mechanisms of encephalopathy [0.03%]
脑糖皮质淋巴管系统：结构、调节、老化及脑功能障碍机制
Danrui Zhao,Junting Wang,Fengji Zhang et al.
Danrui Zhao et al.
The glymphatic system was initially considered as a perivascular channel, responsible for the clearance of substances within the brain. With the deepening comprehension of the functions of the extracellular space (ECS) and the discovery of ...
Influence of patient characteristics on efficacy and safety of anti-amyloid monoclonal antibodies in Alzheimer's disease: A systematic review and meta-analysis [0.03%]
阿尔茨海默病患者特征对抗淀粉样蛋白单克隆抗体有效性和安全性的影响力：系统回顾和meta分析
Grace H Shim,Edward C Y Lau,Andrew L H Huynh et al.
Grace H Shim et al.
Background: Lecanemab and donanemab are the first anti-amyloid monoclonal antibodies (mAbs) clinically available as disease-modifying therapies for Alzheimer's disease (AD). However, it remains unclear whether their treat...
Huntingtin protein in health and Huntington's disease: Molecular mechanisms, pathology and therapeutic strategies [0.03%]
健康与亨廷顿舞蹈病中的狩猎tin蛋白：分子机制、病理及治疗策略
Rinku Shaha,Angel Godad
Rinku Shaha
Huntington's Disease (HD) is a neurodegenerative, genetic disorder that affects the brain and is caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide in the huntingtin (HTT) gene exceeding 35 units. Further, the mutation ...
Exercise-Induced Inflammatory and Metabolic adaptations in Ageing: A Meta-Analytic Compendium [0.03%]
运动诱导的衰老炎症和代谢适应：元分析汇编
Mr Rocco Sheldon,Mr Andrew Gan,Ms Jennifer Tasong et al.
Mr Rocco Sheldon et al.
Background: The relationship between metabolic and inflammatory adaptations with exercise training is poorly quantified. We employed a novel meta-analytical approach to provide an evidence-based framework to guide exercis...
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: from pathological mechanism to therapeutic potentials [0.03%]
cGAS-STING介导的衰老相关视网膜疾病炎症级联通路：从病理机制到治疗潜力
Xiaosu Wang,Zhihui Feng,Sa Sun et al.
Xiaosu Wang et al.
Aging-related retinal diseases lead to irreversible structural damages and vision loss. These conditions are characterized by cellular senescence, oxidative stress, neural degeneration, and neovascularization. Among these, chronic inflammat...
Characterizing patterns in causes, risk factors, and life expectancy among the oldest old (aged 95+ years) [0.03%]
我国高龄老人（95岁以上）死亡原因、风险因素和预期寿命的特征分析
Haoxian Tang,Xiaojing Chen,Jingtao Huang et al.
Haoxian Tang et al.
Background: The global population is aging rapidly, extending into the oldest old. However, increased longevity does not always translate into enhanced health. While genetic and environmental factors influence lifespan, e...
Decoding Senescent Drivers in Alzheimer's Disease: From Bench to Bedside [0.03%]
阿尔茨海默病的衰老驱动因素解析：从实验室到临床
Runjin Zhou,Xiaoling Lin,Zhenge Liao et al.
Runjin Zhou et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with dementia. Cellular senescence, widely acknowledged as a key hallmark of aging, has increasingly been recognized as a significant factor in the pathogenes...
Protein post-translational modifications in sepsis: molecular mechanisms and biomarkers [0.03%]
脓毒症中的蛋白质翻译后修饰：分子机制与生物标志物
Yuze Wang,Hongyi Li,Qian Zhao et al.
Yuze Wang et al.
Sepsis is a common and highly fatal condition in intensive care units and is one of the leading causes of death worldwide. As a clinically complex syndrome with intricate pathophysiology, early identification and assessment of sepsis remain...
Progress in anti-ageing drug research for age-related diseases: A review [0.03%]
抗衰老药物研究进展：延缓与年龄有关的疾病发生
Zi-Ying Zhou,Hao-Tian Duan,Si-Tu Xue et al.
Zi-Ying Zhou et al.
This review explores the anti-ageing potential of nine repurposed drugs: aspirin, atorvastatin, enalapril, metformin, canagliflozin, liraglutide, acarbose, N-acetylcysteine and dasatinib (commonly combined with quercetin). Specifically, it ...
The therapeutic potential of early exercise in Alzheimer's disease: Focus on the brain-spleen axis [0.03%]
阿尔茨海默病的早期运动治疗潜力：着重于脑-脾轴
Tao Wang,Lili Feng,Zhenjun Tian
Tao Wang
Alzheimer's disease (AD) is the predominant cause of cognitive dysfunction, with global prevalence increasing annually. AD progression is principally driven by the accumulation of amyloid-β (Aβ) and hyperphosphorylated microtubule-associa...