Organelle interactome disruption: The systemic pathological mechanisms and therapeutic prospects of mitochondria-lysosome-ER crosstalk in Alzheimer's disease [0.03%]
Liping Xing,Annan Liu,Wei Gao et al.
Liping Xing et al.
The traditional pathological framework of Alzheimer's disease (AD) primarily focuses on the accumulation of β-amyloid (Aβ) and tau proteins. However, therapeutic strategies targeting these molecules have repeatedly encountered setbacks in...
Multifaceted cell death in atherosclerosis: Mechanisms, pathological impact, and therapeutic targeting [0.03%]
Wang-Jing Mu,Shi-Qi Wei,Wan-Qiu Peng et al.
Wang-Jing Mu et al.
Atherosclerosis (AS) is a chronic inflammatory vascular disease associated with aging, the initiation and progression of which is closely related to multiple cell death pathways. This review systematically elucidates the specific activation...
The role and mechanisms of methylation modifications in the development and progression of hypertension [0.03%]
Hongxia Niu,Yilei Kong,Zehua Liu et al.
Hongxia Niu et al.
Hypertension is a globally prevalent cardiovascular disorder with a multifactorial etiology involving genetic variations, environmental cues, aging and their complex interactions. Despite extensive research, the precise molecular mechanisms...
Xin Li,Kang-Cheng Fan,Gui-Yan Sun et al.
Xin Li et al.
Aging is a complex biological process characterized by the loss of metabolic homeostasis, epigenetic drift, and systemic functional decline. Although exercise is widely recognized as a potent non-pharmacological intervention for aging, the ...
Jing Yu,Bingbing Fan,Xiaoyan Gao et al.
Jing Yu et al.
The liver performs a wide range of physiological functions, including lipid/glucose metabolism, energy storage, immune regulation, molecular biosynthesis, and the clearance of xenobiotics, all of which are essential for maintaining systemic...
Yan Zhang,Lianli Gan,Shixuan Wang et al.
Yan Zhang et al.
The global aging population presents a pressing challenge, highlighting the urgent need for interventions that target the fundamental mechanisms of aging. Gene therapy, leveraging its success in treating monogenic and aging-related diseases...
Mapping the landscape of Hutchinson-Gilford Progeria Syndrome research: A bibliometric analysis (1995-2025) [0.03%]
Atharva Kharul,Harshita Chhallani,Kshitij Jadhav et al.
Atharva Kharul et al.
Background: Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare hereditary condition caused by germline de novo mutations of LMNA gene that synthesizes the toxic protein progerin and, therefore, compromises nucle...
The multi-target cardiac protection mechanism of butylphthalide and AI-driven precision medicine: From molecular basis to clinical translation [0.03%]
丁苯酞多靶心肌保护机制与人工智能精准医学：从分子基础到临床转化
Feng Zhang,Xiangying Deng,Xuelun Zou et al.
Feng Zhang et al.
Butylphthalide (NBP) is a lipophilic small-molecule drug characterized by its multi-target and multi-pathway regulatory properties. Initially employed in the treatment of ischemic stroke, recent studies have highlighted its significant prot...
Unlocking the Gut-Brain-Heart Axis: Mechanistic insights and therapeutic avenues for sleep and cardiovascular comorbidity [0.03%]
解锁肠-脑-心轴：睡眠与心血管共病的机制见解和治疗途径
Xinge Tang,Aimi Hu,Qinglu Xu et al.
Xinge Tang et al.
Sleep disorders and cardiovascular diseases are pressing global health concerns, whose prevalence and comorbidity significantly increase with age. The mechanistic underpinnings of this bidirectional relationship remain elusive. This review ...