Effects of exercise and nutritional interventions on muscle-specific strength in older adults: A systematic review and meta-analysis [0.03%]
运动和营养干预对老年人肌肉特定力量影响的系统评价和meta分析
Takahisa Ohta,Sho Hatanaka,Jiaqi Li et al.
Takahisa Ohta et al.
Purpose: Deficient muscle-specific strength has been recognized as a key component of sarcopenia. However, the impact of various interventions on muscle-specific strength has not been systematically reviewed. This study a...
Metabolic Reprogramming-Driven Neuroimmunoregulation: Key Mechanisms and Therapeutic Opportunities and Challenges in Central Nervous System Disorders [0.03%]
代谢重组驱动的神经免疫调节：中枢神经系统疾病的关键机制和治疗机遇与挑战
Nan Li,Yuanyuan Wu,Huiyi Feng et al.
Nan Li et al.
Central nervous system (CNS) disorders are fundamentally linked to metabolic dysregulation within immune and glial cells. This review provides a systematic synthesis of immunometabolic reprogramming-encompassing glucose, lipid, and amino ac...
Metabolic reprogramming-driven neuroimmunoregulation: Key mechanisms and therapeutic opportunities and challenges in central nervous system disorders [0.03%]
代谢重塑驱动的神经免疫调节：中枢神经系统疾病中的关键机制和治疗机遇与挑战
Nan Li,Yuanyuan Wu,Huiyi Feng et al.
Nan Li et al.
Central nervous system (CNS) disorders are fundamentally linked to metabolic dysregulation within immune and glial cells. This review provides a systematic synthesis of immunometabolic reprogramming-encompassing glucose, lipid, and amino ac...
Acute lung injury in the context of aging: Pathogenetic mechanisms and therapeutic strategies [0.03%]
老龄化背景下急性肺损伤的发生机制与治疗策略
Jiawang Huang,Zhiying Feng,Jingmin Fu et al.
Jiawang Huang et al.
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), remain major challenges in critical care medicine, characterized by alveolar-capillary barrier disruption, excessive inflammation, and impaired gas exc...
Mitochondrial homeostasis dysregulation: Potential mechanisms of Alzheimer's disease mediated by TDP-43 [0.03%]
线粒体稳态失衡：TDP-43介导的阿尔茨海默病潜在机制
Wendi Huang,Juan Huang,Nanyu Kuang et al.
Wendi Huang et al.
Alzheimer's disease (AD) exhibits substantial clinical and pathological heterogeneity that is not fully explained by amyloid-β and tau pathology alone. TAR DNA-binding protein 43 (TDP-43) is increasingly recognized as a frequent copatholog...
Experience-driven neural efficiency and reserve in aging: Evidence from bilingual attentional adaptation [0.03%]
基于双语注意适应的老化驱动神经效率和储备的证据
John G Grundy,Febriana Grundy
John G Grundy
Bilingualism offers a powerful test case for understanding how control systems adapt to sustained, variable attentional demands. Converging evidence across behavioral, structural, functional, and clinical literatures indicates that repeated...
How do energy metabolism disorders and neuroinflammation collectively contribute to the pathogenesis of Alzheimer's disease? [0.03%]
能量代谢障碍和神经炎症如何共同促成了阿尔茨海默病的发病机制？
Yinuo Lei,Liyang Liu,Yi Tang
Yinuo Lei
Alzheimer's disease (AD), as the leading cause of dementia, poses an increasingly severe socioeconomic burden in the context of global ageing. Traditionally defined by amyloid-β and tau pathology, it's increasingly recognized as a systems ...
Aging at the neurovascular interface: an integrative framework linking cardiovascular and cerebrovascular diseases [0.03%]
神经血管界面衰老：一个整合框架，连接心血管和脑血管疾病
Kexin Chen,Jun Ma,Yong Peng
Kexin Chen
Aging is a fundamental driver of cardiovascular and cerebrovascular comorbidities, yet the mechanisms linking aging to concurrent heart and brain diseases remain incompletely understood. The neurovascular interface (NVI) refers to the struc...
The Physical Senotype in cellular senescence: Mechanical and physical strategies for senotherapy [0.03%]
细胞衰老中的物理表型：用于衰老治疗的机械和物理策略
Bingjie Wang,Xiangqing Qi,Johnny Huard et al.
Bingjie Wang et al.
Cellular senescence is traditionally described through durable cell-cycle arrest, DNA-damage signaling, metabolic remodeling, mitochondrial and lysosomal dysfunction, and acquisition of a senescence-associated secretory phenotype (SASP). Ho...
Cellular senescence at the bidirectional interface between ageing and coronary artery disease [0.03%]
细胞衰老在双向连接衰老和冠状动脉疾病之间的作用
Xinxin Li,Hanwen Zhang,Mengjia Chen et al.
Xinxin Li et al.
Coronary artery disease (CAD) is a major global cause of morbidity and mortality, and population ageing is reshaping its clinical phenotype, disease trajectory, and therapeutic complexity. Chronological age alone cannot explain the heteroge...