Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration [0.03%]
基于血液的生物标志物在阿尔茨海默病早期检测和年龄相关神经退行性疾病监测中的应用进展
Wenting Fu,Paul Chi-Lui Ho
Wenting Fu
Alzheimer's disease (AD) presents a critical global challenge, accounting for over 60 % of the 57 million current dementia cases worldwide, with prevalence projected to exceed 100 million by 2050. Traditional diagnostic approaches, such as ...
From Ageing Clocks to Organ Networks: Biological Age-Driven Organ Asynchrony and Inter-organ Interactions Shaping Mortality Risk [0.03%]
从衰老时钟到器官网络：生物年龄驱动的器官异步和器官间相互作用塑造死亡风险
Zhenyu Li,Jiahao Liu,Yaoyao Dai et al.
Zhenyu Li et al.
Ageing is a multidimensional and heterogeneous process that progresses asynchronously across organ systems. Advances in multi-omics technologies have led to the development of diverse ageing clocks, including epigenetic, proteomic, metabolo...
NAD⁺ supplementation for anti-aging and wellness: a PRISMA-guided systematic review of preclinical and clinical evidence [0.03%]
辅酶I增补剂在抗衰老和健康促进中的作用：一项基于PRISMA的系统综述
Cory Gallagher,Owoturo Oluwaseun Emmanuel
Cory Gallagher
Nicotinamide adenine dinucleotide (NAD⁺) declines with age, motivating "NAD⁺-boosting" strategies ranging from lifestyle interventions to supplementation with NAD⁺ precursors (e.g., nicotinamide riboside [NR], nicotinamide mononucleotide...
Neuroimmune Dysregulation in Alzheimer's Disease: Mechanisms and Therapeutic Strategies [0.03%]
阿尔茨海默病的神经免疫失调：机制和治疗策略
Haili He,Shijie Zhu,Can Zhang et al.
Haili He et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by progressive memory loss and cognitive decline. With the global population ageing, the prevalence of AD continues to rise, posing a significant public health challenge...
Zhuang Zhuang Han,João Pedro de Magalhães
Zhuang Zhuang Han
Recent advances in biogerontology show that ageing is malleable, opening the possibility of delaying chronic disease and extending healthspan. Ethical debate has been dominated by consequentialist framings, balancing potential benefits agai...
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, and therapeutic implications [0.03%]
阿尔茨海默病中小胶质细胞的代谢重编程：途径、机制和治疗意义
Feng-Ge Yang,He Yang,Sheng-Wang Han et al.
Feng-Ge Yang et al.
In recent years, the immune metabolism of central nervous system cells has gained increasing attention from researchers. Microglia (MG) are innate immune cells of the central nervous system. They can metabolize a wide range of energy substr...
Mitochondrial transfer: A novel mechanism and promising therapeutic strategy in ageing kidney [0.03%]
线粒体转移：在衰老肾脏中一种新颖的机制和有前景的治疗策略
Jingge Xu,Xingyi Li,Zhiyu Zhang et al.
Jingge Xu et al.
As a metabolically active organ, kidney has to challenge progressive functional decline with ageing. Meantime, in the pathogenesis of kidney diseases, renal dysfunction also accelerates an individual's ageing trajectory, leading to prematur...
Blood Flow and Angiogenesis; Major Mechanisms Mediating Healthful Longevity [0.03%]
血液流动与血管生成；促进健康长寿的主要机制
Jie Zhang,Dorothy E Vatner,Ahmed Gad et al.
Jie Zhang et al.
While human lifespan has increased dramatically over the past century, the extension of healthspan, the period free of chronic age-related disease, has lagged behind. Blood flow and angiogenesis are significantly reduced in aging humans, pl...
Aging and neuropathic pain: Mitochondria-to-glia cascade, system mechanisms, and therapeutic strategies [0.03%]
衰老与神经病理性疼痛：线粒体-胶质细胞级联反应、系统机制及治疗策略
Shreyasi Majumdar,Puneet K Samaiya,Sukesh Kumar Gupta et al.
Shreyasi Majumdar et al.
Neuropathic pain (NP) creates a severe pathological condition that primarily affects elderly people because of their accumulated neurobiological changes that make them more susceptible to persistent pain. The aging process leads to multiple...
Gut Microbiota-Derived Metabolites as Immune Modulators in Aging and Age-Related Chronic Inflammatory Diseases [0.03%]
肠道微生物代谢产物在衰老及相关慢性炎症性疾病中的免疫调节作用
Nan Chen,Carmen K Chan,Farhan Ullah Khan et al.
Nan Chen et al.
Age-associated dysbiosis, marked by shifts in the composition of gut microbiota and gut microbiota-derived metabolites (GMDMs), is increasingly implicated in driving systemic low-grade inflammation during aging. The disrupted GMDM pools, in...