Marja Jylhä,Caleb E Finch
Marja Jylhä
Socio-economic status (SES) impacts life-long health from early development to old age. We review SES differences in biological factors that begin before fertilization and extend into later life, 'egg to exit'. SES gradients are shown in on...
HADHA in Cardiovascular Disease: From Mitochondrial Dysfunction to Therapeutic Targets [0.03%]
线粒体功能异常介导的心血管疾病及其治疗靶点的研究进展：汉达汗基因的视角
Yichen Qi,Siyu Guo,Xinming Cai et al.
Yichen Qi et al.
HADHA, encoding the α-subunit of MTP, plays a pivotal role in long-chain fatty acid β-oxidation and mitochondrial energy homeostasis. HADHA dysfunction disrupts energy balance by causing toxic metabolite buildup, impairing oxidative phosp...
The p75NTR signaling axis: Bridging neurodevelopmental homeostasis, pathological mechanisms, and therapeutic strategies in neurodegenerative diseases [0.03%]
p75NTR信号轴：连接神经发育稳态、病理机制和神经退行性疾病治疗策略
Jiawei Wu,Haixin Ma,Xiaochen Niu et al.
Jiawei Wu et al.
The neurotrophin receptor p75 (p75NTR) plays dual, context-dependent roles in the nervous system that are regulated by ligand binding, co-receptor interactions, and microenvironmental cues. During neurodevelopment, synaptic plasticity, and ...
Tau phosphorylation homeostasis: Mechanisms, targets, and therapeutic implications in Alzheimer's disease [0.03%]
tau磷酸化稳态：阿尔茨海默病中的机制、靶点和治疗意义
Shengwen Lu,Shi Qiu,Yu Guan et al.
Shengwen Lu et al.
Neurofibrillary tangles, composed of excessively phosphorylated tau, are a core neuropathological hallmark of Alzheimer's disease (AD). However, therapeutic strategies aimed at directly clearing neurofibrillary tangles have demonstrated lim...
Xueer Zheng,Yiming Wu,Yuchong Feng et al.
Xueer Zheng et al.
Aging is a multifactorial process characterized by a gradual decline in function, increased susceptibility to diseases, and diminished regenerative capacity. As the primary refractive structure and barrier of the eye, the cornea undergoes s...
Lactate-lactylation axis as an emerging metabolic-epigenetic pathway in diabetic microvascular complications [0.03%]
乳酸-乳酸化轴在糖尿病微血管并发症中的代谢-表观遗传作用通路
Yue Zhou,Yunkao Zeng,Junming Wang et al.
Yue Zhou et al.
Lactate, once viewed merely as a glycolytic byproduct, is now recognized as a key signaling molecule and epigenetic regulator through the recently identified post-translational modification known as lactylation. In diabetic microvascular co...
Sleep health in the older adults: Architecture, circadian changes, and common sleep disorders [0.03%]
老年人的睡眠健康：建筑，昼夜变化和常见的睡眠障碍
Raghad Alhajaji,Haitham Jahrami,Seithikurippu R Pandi-Perumal et al.
Raghad Alhajaji et al.
Population aging accelerates globally, increasing sleep-related complaints among older adults. These disorders substantially impact cognitive function, physical health, and quality of life. This narrative review examines age-related changes...
Oligodendrocyte Dysfunction in Alzheimer's Disease: Integrating Spatial Epigenomics and Metabolic Circuitry in Demyelination - A Critical Review [0.03%]
阿尔茨海默病中少突胶质细胞功能障碍：整合空间表观基因组学和脱髓鞘代谢通路- 重要综述
Lian Jian,Yuqing Liu,Weijun Peng
Lian Jian
Traditional Alzheimer's disease (AD) research has predominantly focused on neuronal pathology within the amyloid-tau-neurodegeneration (ATN) framework, emphasizing β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTS), and neuroinflammat...
Renal inflammaging: Mechanisms, pathophysiology and therapeutic prospects [0.03%]
肾脏炎症衰老：机制、病理生理和治疗前景
Jing Yan,Fuying Zhao,Ruitong Zhang et al.
Jing Yan et al.
The ageing global population faces a rising prevalence of chronic kidney disease (CKD), now recognized as a state of accelerated ageing driven by chronic low-grade inflammation-inflammaging. This review synthesizes current evidence position...
The STAT3 paradox in aging: Molecular mechanisms and targeted therapeutic strategies [0.03%]
STAT3衰老悖论：分子机制与靶向治疗策略
Tianshu Yang,Shengqi Huo,Wei Shi
Tianshu Yang
Population aging has become a global challenge, with its molecular mechanisms incompletely understood. The signal transducer and activator of transcription 3 (STAT3), a pleiotropic cytoplasmic transcription factor, is extensively involved i...