Metabolic and inflammatory roles of glial cells in neurodegenerative and cerebrovascular diseases [0.03%]
神经退行性和脑血管疾病中胶质细胞的代谢和炎症作用
Femi Abiola Ogunleye,Yumei Zhou,Lan Yan et al.
Femi Abiola Ogunleye et al.
Chronic neuroinflammation is a hallmark of neurodegenerative and cerebrovascular diseases and is largely driven by dysfunctional activation of microglia and astrocytes. Recent advances in single-cell transcriptomics and metabolic profiling ...
Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload [0.03%]
脂肪酸诱导的表观遗传重编程：脂质过载期间的染色质修饰和细胞衰老
Karla Estephanía Ávila-Galicia,Adriana Alarcón-Aguilar,Ernesto Soto-Reyes et al.
Karla Estephanía Ávila-Galicia et al.
Cellular senescence is a stable cell state sustained by specific gene expression programs that are established and maintained through dynamic changes in chromatin organization. Importantly, these programs are highly dependent on the nature ...
S100A8/A9 as a central hub in inflammaging: Cross-system mechanisms [0.03%]
S100A8/A9在炎性老化中的核心作用：跨系统机制
Shiyu Wang,Yiming Ni,Jiawei Feng et al.
Shiyu Wang et al.
Global population aging intensifies "inflammaging," a bidirectional link between chronic inflammation and aging-related pathology. Among them, S100A8/A9 forms a positive feedback loop of "aging-inflammation". Here, we systematically review ...
Lipid Metabolism and Neurodegeneration: Mechanistic Insights and Therapeutic Targets [0.03%]
脂代谢与神经退行性病变：机制和治疗靶点的新视野
Yessenia Marroquin Salas,Kevin M Kemper,Santhanam Shanmughapriya et al.
Yessenia Marroquin Salas et al.
Lipid metabolism plays a crucial role in maintaining brain homeostasis, affecting energy balance, membrane structure, and signaling pathways essential for neuronal and glial health. Disruption of lipid pathways is linked to neuroinflammatio...
Testicular aging revisited: Current understanding of mechanisms and emerging interventions [0.03%]
重新审视睾丸衰老：当前对机制和新兴干预措施的理解
Feng Jiang,Xianglong Wang,Na Wang et al.
Feng Jiang et al.
Male reproductive aging is a complex physiological process characterized by progressive deterioration in spermatogenesis, hormonal imbalance, and increased susceptibility to infertility and genetic disorders. This review comprehensively sum...
Myeloid cell nuclear differentiation antigen (MNDA) is an interferon-inducible regulator of myelopoiesis. Potential role in the myeloid-biased aging process [0.03%]
髓系细胞核分化抗原(MNDA)是一种干扰素诱导的髓样细胞发育调控因子。在髓系偏向性衰老过程中的潜在作用
Antero Salminen,Kai Kaarniranta,Anu Kauppinen
Antero Salminen
Aging is a myeloid-biased process, i.e., the differentiation of myeloid cells increases, while the lymphoid lineage declines. Cellular senescence increases the secretion of inflammatory mediators which skew hematopoiesis toward myeloid cell...
Cellular senescence in neurodegenerative diseases: a bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications [0.03%]
细胞衰老在神经退行性疾病中的作用：基于文献计量学的分析及连接转化医学路径与治疗意义的机制综合研究
Runjin Zhou,Xiaoling Lin,Jian Lin et al.
Runjin Zhou et al.
Background: Cellular senescence is now recognized as a pivotal driver of neurodegenerative diseases (NDs). Despite advances in understanding senescence mechanisms, such as the p16INK4A/p53-p21CIP1 pathways and the senesce...
Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging [0.03%]
模型培养皿中的衰老：迈向更复杂的体外人类皮肤衰老模型的发展
Stefania Briganti,Emanuela Camera,Jesús Ciriza et al.
Stefania Briganti et al.
With age, human skin undergoes a progressive decline in essential functions, including barrier protection, immunity, and wound healing capacity, which underlie many age-related skin diseases. Skin aging is not only driven by chronological a...
Neighbourhood environments and later life flourishing: A systematic scoping review [0.03%]
生活环境与老年幸福：系统综述研究
Yeqing Zhang,Rolando Leiva-Granados,Qi Rui Soh et al.
Yeqing Zhang et al.
Background: Enabling older people to live comfortably in their own neighbourhoods for longer, known as ageing-in-place, has become a policy priority to reduce pressures on health and social care systems amid global popula...
Hallmarks of healthy cognitive aging: inter-individual differences in aging trajectories [0.03%]
健康认知衰老的标志：衰老轨迹的个体间差异
Djoher Nora Abrous,Nicolas Blin,Carl-Johan Boraxbekk et al.
Djoher Nora Abrous et al.
Cognitive aging is a highly heterogeneous process, with some individuals preserving stable cognitive performance across the lifespan while others exhibiting pronounced decline. This marked interindividual variability indicates that chronolo...