Machine learning for frailty assessment and outcome prediction in cardiovascular disease: A scoping review [0.03%]
心血管疾病中用于脆弱性评估和结果预测的机器学习：系统综述
Jack Quach,Olga Theou,Selena Maxwell et al.
Jack Quach et al.
Background: Frailty is common among individuals with cardiovascular disease (CVD) and is a strong predictor of adverse outcomes. Machine learning (ML) methods have been applied independently in CVD research for risk predi...
Decoding the secretase puzzle in amyloid-β generation: A state-of-the-art overview of the protease-mediated APP processing cascade in Alzheimer's disease [0.03%]
阿尔茨海默病淀粉样蛋白生成的分泌酶之谜破解：泛素介导的APP加工串珠路易体疾病状态概述
Zuzanna Senkowska,Ewelina Weglarz-Tomczak
Zuzanna Senkowska
The accumulation of amyloid β (Aβ) protein in the brain is a central pathological hallmark of Alzheimer's disease (AD). This process has become a major focus of interdisciplinary research and a critical target in drug development. Aβ is ...
Research progress on carotid artery changes and cognitive impairment in Alzheimer's disease patients [0.03%]
阿尔茨海默病患者颈动脉改变与认知功能损害的关系研究进展
Xiaorui Li,Xiaoyun Feng,Anlin Cai et al.
Xiaorui Li et al.
This article aims to comprehensively analyze the vascular factors in Alzheimer's Disease (AD), particularly the changes in the carotid arteries, and their complex correlations with hippocampal atrophy and cognitive function. Besides the tra...
Ageing and the lymphatic system: Implications for immunity, brain health, and possible therapeutic interventions [0.03%]
衰老与淋巴系统：对免疫、脑健康以及可能的治疗干预的影响
M N Rojas Velazquez,E Gousopoulos,S Wolf et al.
M N Rojas Velazquez et al.
The lymphatic system is essential for maintaining interstitial fluid balance, supporting immune surveillance, and clearing metabolic waste, yet its role in ageing has only recently come into focus. With age, lymphatic vessels and lymphoid o...
How does social health impact cognitive function and brain reserve? Findings from the SHARED Consortium [0.03%]
社会健康如何影响认知功能和脑储备？SHARED研究联盟的发现
Suraj Samtani,Jean Stafford,Dorota Szcześniak et al.
Suraj Samtani et al.
Background: Social health is increasingly recognised as an important factor influencing cognitive ageing and experiences of dementia. Yet definitions and measurements remain inconsistent, and evidence on how social health...
Nuclear receptors in age-related diseases: from mechanisms to drug discovery [0.03%]
核受体在衰老相关疾病中的作用：从机制到药物发现
Lijun Zhang,Xiangyi Li,Chanjuan Ren et al.
Lijun Zhang et al.
Nuclear receptors (NRs), a superfamily of ligand-activated transcription factors, serve as master regulators linking signaling molecules to the genome, coordinating a variety of essential physiological processes in development, homeostasis,...
Kaitlyn H Hajdarovic,Nicole C Riddle,Ashley E Webb
Kaitlyn H Hajdarovic
Interventions to extend lifespan and healthspan are of major interest, but such interventions may affect male and female organisms differently. Whether this is due sex-specific differences in baseline lifespan, or differences in sexually di...
When expert agreement replaces evidence: The rise of Delphi consensus in geriatrics [0.03%]
当专家共识取代证据：老年病学中德尔菲共识的兴起
Hélio José Coelho-Júnior,Emanuele Marzetti
Hélio José Coelho-Júnior
Expert consensus is intended to guide clinical reasoning when evidence is scarce. In contemporary geriatrics, however, the Delphi method is increasingly used where data are not absent but abundant. Sarcopenia and frailty exemplify this dile...
Endothelial cell senescence and mitochondrial dysfunction in vascular ageing [0.03%]
内皮细胞衰老和线粒体功能障碍在血管衰老中的作用
Iga Walczak,Maria Tarnawska,Klaudia Stawarska et al.
Iga Walczak et al.
The vascular endothelium performs numerous regulatory functions that impact inflammatory responses, thrombosis, vascular tone and angiogenesis. Endothelial dysfunction is a key contributor to the pathogenesis of various human diseases, eith...
Manyv Zheng,Wenya Su,Luyao Tian et al.
Manyv Zheng et al.
The aging of the vasculature is a primary determinant of cardiovascular disease risk and a key contributor to organismal decline. While our understanding of its molecular underpinnings has grown exponentially, the translation of these disco...