Age-associated regulation of chondrocyte hypertrophy in osteoarthritis: Mechanisms, therapeutic implications, and cartilage fate reprogramming [0.03%]
骨关节炎软骨细胞肥大的年龄依赖性调控：机制、治疗意义和软骨细胞命运重塑
Jong Seong Ha,Anna Jo,Eon Ji Yeo et al.
Jong Seong Ha et al.
Osteoarthritis (OA) is a prevalent age-associated joint disease marked by progressive cartilage loss, subchondral bone remodeling, osteophyte formation, and low-grade inflammation. In OA, articular chondrocytes shift from a stable extracell...
Nanomedicine Guiding Mitochondrial Function in the Treatment of Cardiovascular Diseases: Mechanisms, Latest Developments, and Clinical Translation [0.03%]
纳米医学引导线粒体功能在心血管疾病治疗中的作用：机制、最新进展和临床转化
Fuyun Jia,Xiangchen Xia,Yuchen Song et al.
Fuyun Jia et al.
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, and ageing is their strongest biological risk factor. In the ageing cardiovascular system, mitochondrial dysfunction is not only a central driver ...
The impact of ageing on faecal short chain fatty acids levels in apparently healthy adults: A systematic review and meta-analysis [0.03%]
衰老对健康成年人粪便中短链脂肪酸水平影响的系统评价和meta分析
Saleha Alqarni,Jennifer Pugh,Valentine Deremiens et al.
Saleha Alqarni et al.
Ageing is accompanied by physiological and lifestyle changes that may influence gut microbial metabolism. Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are microbial metabolites derived from dietary fibre fer...
High-throughput screening for ageing and age-related disease drug discovery: Advances and challenges [0.03%]
高通量筛选在衰老及相关疾病药物研发中的应用：进展与挑战
Xingkun Ji,Yan Pan,Jiajun Lei et al.
Xingkun Ji et al.
Ageing is the primary risk factor for many chronic, degenerative, and life-threatening disorders, yet the translational pipeline for geroprotective interventions remains comparatively sparse. Short‑lived, experimentally tractable models wi...
Mechanistic Research and Therapeutic Prospects of Alternative Splicing in Neurodegenerative Diseases [0.03%]
神经退行性疾病中可变剪接的机制研究和治疗前景
Xiaolan Ran,Mei Wang,Juan Huang et al.
Xiaolan Ran et al.
One essential post-transcriptional regulatory mechanism that increases protein diversity in eukaryotes is alternative splicing. This process is crucial for maintaining nervous system function and is highly active in neurons. Dysregulation o...
Lysosomal control of aging through transcriptional and epigenetic regulation [0.03%]
溶酶体通过转录和表观遗传调控控制衰老
Yikai Bai,Yu Luo,Yuyuan Wang et al.
Yikai Bai et al.
Despite the well-known role as degradative organelles, lysosomes have been identified as a central signaling hub in maintaining cellular homeostasis. Lysosomal dysfunction is a well-established driver of cellular senescence and age-related ...
The role and therapeutic potential of DNA glycosylases in Alzheimer's disease [0.03%]
DNA糖基化酶在阿尔茨海默病中的作用和治疗潜力
Xia Zhao,Yingzhou Li,Ziyao Meng et al.
Xia Zhao et al.
The aging brain is highly vulnerable to oxidative genomic damage, the accumulation of which is a hallmark of Alzheimer's disease (AD). The base excision repair (BER) pathway, initiated by DNA glycosylases, serves as the primary guardian aga...
Drug repurposing in Alzheimer's disease: Emerging therapeutic strategies and promising candidates [0.03%]
阿尔茨海默病的药物再定位：新兴的治疗策略和有前景的候选药物
Pradip S More,Shyam W Rangari,Swati N Lade et al.
Pradip S More et al.
Alzheimer's disease is a progressive neurodegenerative disorder, and the most common cause of dementia, which causes 60-70 % of cases worldwide, and its prevalence is increasing by more than 55 million people globally, with an expected incr...
Mitochondria-associated endoplasmic reticulum membranes as aging-sensitive signaling hubs in degenerative musculoskeletal diseases [0.03%]
线粒体相关内质网膜在退行性肌肉骨骼疾病中的衰老敏感信号中心作用
Linbo Peng,Kexin Wang,Limin Wu et al.
Linbo Peng et al.
Degenerative musculoskeletal diseases (DMDs), including osteoarthritis, osteoporosis, sarcopenia, and intervertebral disc degeneration, are highly prevalent age-related conditions characterized by progressive tissue dysfunction and loss of ...
Psychological research on Alzheimer's disease in Pakistan: A systematic review of current trends and research gaps [0.03%]
巴基斯坦阿尔茨海默病的心理学研究：现有趋势和研究缺口的系统回顾
Amna Aurooj,Shalmee Emmanuel,Mehwish Jabeen et al.
Amna Aurooj et al.
Alzheimer's disease (AD) is an escalating public health concern in low- and middle-income countries like Pakistan, with rising prevalence among the aging population. While global research has increasingly addressed the psychological dimensi...