Quantification of GABAA receptors in the rat brain with [(123)I]Iomazenil SPECT from factor analysis-denoised images [0.03%]
基于因子分析去噪图像的纹状体外神经元模型中的多巴胺能可塑性
Stergios Tsartsalis,Marcelle Moulin-Sallanon,Noé Dumas et al.
Stergios Tsartsalis et al.
Purpose: In vivo imaging of GABAA receptors is essential for the comprehension of psychiatric disorders in which the GABAergic system is implicated. Small animal SPECT provides a modality for in vivo imaging of the GABAer...
Preparation of Ga-68-NOTA as a renal PET agent and feasibility tests in mice [0.03%]
Ga-68-NOTA的制备及其在小鼠体内的肾显像研究
Ji Youn Lee,Jae Min Jeong,Young Ju Kim et al.
Ji Youn Lee et al.
Introduction: Positron emission tomography (PET) may provide more accurate quantification of kidney function such as glomerular filtration rate (GFR) than gamma imaging. The purpose of these experiments was to prepare and...
Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancer [0.03%]
Cu-64标记的AS1411适配子在肺癌显像中的初步评价研究
Junling Li,Huaiyu Zheng,Paula J Bates et al.
Junling Li et al.
Introduction: AS1411 is a 26-base guanine-rich oligonucleotide aptamer shown binding to surface nucleolin, a protein over-expressed in multiple cancer cells, thus AS1411 labeled with a PET isotope can be explored as a pot...
Optimization of reaction conditions for the radiolabeling of DOTA and DOTA-peptide with (44m/44)Sc and experimental evidence of the feasibility of an in vivo PET generator [0.03%]
DOTATOC和DOTA的44m,44Sc放射性标记反应条件的优化及体内PET发生器可行性实验研究
S Huclier-Markai,R Kerdjoudj,C Alliot et al.
S Huclier-Markai et al.
Introduction: Among the number of generator systems providing radionuclides with decay parameters promising for imaging and treatment applications, there is the (44)Ti (T1/2=60 years)/(44)Sc (T1/2=3.97 h) generator. This ...
Future prospects for SPECT imaging using the radiolanthanide terbium-155 - production and preclinical evaluation in tumor-bearing mice [0.03%]
放射性镧系元素Terbium-155用于SPECT成像的前景-生产和肿瘤小鼠模型中的前临床评估研究
Cristina Müller,Eliane Fischer,Martin Behe et al.
Cristina Müller et al.
Introduction: We assessed the suitability of the radiolanthanide (155)Tb (t1/2=5.32 days, Eγ=87 keV (32%), 105keV (25%)) in combination with variable tumor targeted biomolecules using preclinical SPECT imaging. ...
Measurements of (186)Re production cross section induced by deuterons on (nat)W target at ARRONAX facility [0.03%]
采用氘核轰击靶测量(186)Re产生截面
Arnaud Guertin,Charlotte Duchemin,Ferid Haddad et al.
Arnaud Guertin et al.
Introduction: The ARRONAX cyclotron, acronym for "Accelerator for Research in Radiochemistry and Oncology at Nantes Atlantique" is a new facility installed in Nantes, France. A dedicated program has been launched on produ...
Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901 [0.03%]
TAK-901多靶点Aurora B激酶抑制剂对肿瘤的疗效的临床前FLT-PET和FDG-PET显像研究
Carleen Cullinane,Kelly L Waldeck,David Binns et al.
Carleen Cullinane et al.
Introduction: The Aurora kinases play a key role in mitosis and have recently been identified as attractive targets for therapeutic intervention in cancer. The aim of this study was therefore to investigate the utility of...
Feasibility of baculovirus-mediated reporter gene delivery for efficient monitoring of islet transplantation in vivo [0.03%]
基于杆状病毒的报告基因递送系统监测胰岛移植的可行性研究
Shuai Liu,Yu Pan,Jing Lv et al.
Shuai Liu et al.
Objective: The objective of this study was to explore the feasibility of baculovirus vector-mediated sodium iodide symporter (NIS) gene delivery to monitor islet transplantation. ...
Choice of labeling and cell line influences interactions between the Fab fragment AbD15179 and its target antigen CD44v6 [0.03%]
抗体的Fab片段与抗原的结合活性受抗体标记方式和细胞系表达的影响：以AbD15179和CD44v6为例
Jonas Stenberg,Diana Spiegelberg,Hampus Karlsson et al.
Jonas Stenberg et al.
Medical imaging by use of immunotargeting generally relies on a labeled molecule binding to a specific target on the cell surface. It is important to utilize both cell-based and time-resolved binding assays in order to understand the proper...
Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5) [0.03%]
评估PET放射配体的体内可视化磷酸二酯酶5(PDE5)性能
Rufael Chekol,Olivier Gheysens,Jan Cleynhens et al.
Rufael Chekol et al.
Introduction: The cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) is considered to play an important role in various etiologies such as pulmonary arterial hypertension (PAH) and chronic hear...