Reactor production and electrochemical purification of (169)Er: a potential step forward for its utilization in in vivo therapeutic applications [0.03%]
反应堆生产纯化及电化学纯化 erbium-169 及其潜在的体内治疗应用前景研究
Rubel Chakravarty,Sudipta Chakraborty,Viju Chirayil et al.
Rubel Chakravarty et al.
Introduction: The aim of the present study was to develop and demonstrate a viable method for the reactor production of (169)Er with acceptable specific activity using moderate flux reactor and its purification from (169)...
A heterodimeric [RGD-Glu-[(64)Cu-NO2A]-6-Ahx-RM2] αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors [0.03%]
用于PET成像的前列腺肿瘤αvβ3/GRPr靶向拮抗剂放射示踪剂异二聚体[RGD-Glu-[(64)Cu-NO2A]-6-Ahx-RM2]
Kubra Durkan,Zongrun Jiang,Tammy L Rold et al.
Kubra Durkan et al.
Introduction: In the present study, we describe a (64)Cu-radiolabeled heterodimeric peptide conjugate for dual αvβ3/GRPr (αvβ3 integrin/gastrin releasing peptide receptor) targeting of the form [RGD-Glu-[(64)Cu-NO2A]-...
Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors [0.03%]
金纳米棒介导的高热可增强HPMA共聚物-90Y偶联物治疗前列腺肿瘤的效果
Brandon Buckway,Nick Frazier,Adam J Gormley et al.
Brandon Buckway et al.
Introduction: The treatment of prostate cancer using a radiotherapeutic (90)Y labeled N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer can be enhanced with localized tumor hyperthermia. An (111)In labeled HPMA copolymer...
Radiolabeling of HTE1PA: A new monopicolinate cyclam derivative for Cu-64 phenotypic imaging. In vitro and in vivo stability studies in mice [0.03%]
HTE1PA的新单吡啶甲酸cyclam衍生物的放射性标记：用于Cu-64表型成像。小鼠体外和体内稳定性研究
Mathieu Frindel,Nathalie Camus,Aurore Rauscher et al.
Mathieu Frindel et al.
Introduction: HTE1PA, a monopicolinate-N-alkylated cyclam-based ligand has previously demonstrated fast complexation process, high kinetic inertness and important thermodynamic and electrochemical stability with respect t...
Detection of activated platelets in a mouse model of carotid artery thrombosis with 18 F-labeled single-chain antibodies [0.03%]
一种用于检测动脉血栓小鼠模型中活化血小板的放射性配体分子
Katie Ardipradja,Shinn Dee Yeoh,Karen Alt et al.
Katie Ardipradja et al.
Introduction: Activated platelets are key players in thrombosis and inflammation. We previously generated single-chain antibodies (scFv) against ligand-induced binding sites (LIBS) on the highly abundant platelet glycopro...
Influence of free fatty acids on glucose uptake in prostate cancer cells [0.03%]
游离脂肪酸对前列腺癌细胞葡萄糖摄取的影响
Kim Francis Andersen,Vadim Divilov,Kuntalkumar Sevak et al.
Kim Francis Andersen et al.
Introduction: The study focuses on the interaction between glucose and free fatty acids (FFA) in malignant human prostate cancer cell lines by an in vitro observation of uptake of fluoro-2-deoxy-D-glucose (FDG) and acetat...
68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET [0.03%]
68镓-DOTA-NGR作为正APN分子显像探针的初步研究
Jun Zhang,Xiaoli Lu,Nan Wan et al.
Jun Zhang et al.
Aminopeptidase N (APN) is selectively expressed on many tumors and the endothelium of tumor neovasculature, and may serve as a promising target for cancer diagnosis and therapy. Asparagine-glycine-arginine (NGR) peptides have been shown to ...
Transcriptional response of kidney tissue after 177Lu-octreotate administration in mice [0.03%]
镥-177奥曲肽给药后小鼠肾脏组织转录组反应分析
Emil Schüler,Nils Rudqvist,Toshima Z Parris et al.
Emil Schüler et al.
Introduction: The kidneys are one of the main dose limiting organs in (177)Lu-octreotate therapy of neuroendocrine tumors. Therefore, biomarkers for radiation damage would be of great importance in this type of therapy. T...
The production of radionuclides for nuclear medicine from a compact, low-energy accelerator system [0.03%]
一种紧凑型低能量加速器系统在核医学放射性同位素生产中的应用
William D Webster,Geoffrey T Parks,Dmitry Titov et al.
William D Webster et al.
Introduction: The field of nuclear medicine is reliant on radionuclides for medical imaging procedures and radioimmunotherapy (RIT). The recent shut-downs of key radionuclide producers have highlighted the fragility of th...
Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and (64)Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors [0.03%]
新型血管生成PET示踪剂68Ga-NODAGA-E[c(RGDyK)]2和(64)Cu-NODAGA-E[c(RGDyK)]2的比较研究及人源性异种移植物肿瘤活体成像研究
Jytte Oxboel,Malene Brandt-Larsen,Christina Schjoeth-Eskesen et al.
Jytte Oxboel et al.
Introduction: The aim of this study was to synthesize and perform a side-by-side comparison of two new tumor-angiogenesis PET tracers (68)Ga-NODAGA-E[c(RGDyK)](2) and (64)Cu-NODAGA-E[c(RGDyK)](2) in vivo using human xenog...
Comparative Study
Nuclear medicine and biology. 2014 Mar;41(3):259-67. DOI:10.1016/j.nucmedbio.2013.12.003 2014