Cornelia Hoehr,Elisabeth Oehlke,Francois Benard et al.
Cornelia Hoehr et al.
Introduction: Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid targe...
Optimization of precursor synthesis, formulation and stability of 1'-[18F]fluoroethyl-β-D-lactose ([18F]FEL) for preclinical studies in detection of pancreatic cancer [0.03%]
用于检测胰腺癌的临床前研究中1'-[18F]氟乙基-β-d-乳糖([18F]fel)前体合成、配方和稳定性的优化
Vincenzo Paolillo,Louis De Palatis,Mian M Alauddin
Vincenzo Paolillo
Introduction: 1'-[(18)F]Fluoroethyl-β-D-lactose ([(18)F]FEL) is a new PET imaging agent for early detection of pancreatic cancer and hepatocellular carcinoma. We previously reported the syntheses of [(18)F]FEL using a br...
Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer [0.03%]
一种新型双价靶向载体[DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2]的合成及其生物活性评价：该载体可同时针对前列腺癌的两种不同生物标志物（GRPr/PSMA）
Rajendra Prasad Bandari,Zongrun Jiang,Tamila Stott Reynolds et al.
Rajendra Prasad Bandari et al.
Gastrin-releasing peptide receptors (GRPr) and prostate-specific membrane antigen (PSMA) are two identifying biomarkers expressed in very high numbers on prostate cancer cells and could serve as a useful tool for molecular targeting and dia...
Comparison of 99mTc-TRODAT-1 SPECT and 18 F-AV-133 PET imaging in healthy controls and Parkinson's disease patients [0.03%]
99mTc-TRODAT-1单光子发射计算机断层成像(SPECT)和18F-AV-133正电子发射断层成像(PET)在健康对照组和帕金森病患者中的对比研究
Ing-Tsung Hsiao,Yi-Hsin Weng,Wey-Yil Lin et al.
Ing-Tsung Hsiao et al.
(99m)Tc-TRODAT-1 is the first clinical routine (99m)Tc radiopharmaceutical to evaluate dopamine neurons loss in Parkinson's disease (PD). (18)F-AV-133 is a novel PET radiotracer targeting the vesicular monoamine transporter type 2 (VMAT2) t...
Comparative Study
Nuclear medicine and biology. 2014 Apr;41(4):322-9. DOI:10.1016/j.nucmedbio.2013.12.017 2014
Visualizing inflammation activity in rheumatoid arthritis with Tc-99 m anti-CD4-mAb fragment scintigraphy [0.03%]
用放射性Tc-99m抗CD4-mAb片段显像法观察类风湿关节炎的滑膜炎症活动性
K Steinhoff,M Pierer,J Siegert et al.
K Steinhoff et al.
Purpose: T-cell-located CD4 antigen represents one of the therapeutic targets in rheumatoid arthritis (RA). However, up to now there is no established imaging tool to visualize this target in vivo. The aim of our study wa...
Influence of pegylation and hapten location at the surface of radiolabelled liposomes on tumour immunotargeting using bispecific antibody [0.03%]
聚乙二醇修饰及半抗原在放射性标记脂质体表面的位置对抗双特异性抗体免疫靶向肿瘤的影响
A Rauscher,M Frindel,C Maurel et al.
A Rauscher et al.
Introduction: This paper proposes liposomes as a potential new tool for radioimmunotherapy in solid tumours with a two step targeting system. Tumour pretargeting is obtained by using a monoclonal bispecific antibody (BsmA...
(232)Th(d,4n)(230)Pa cross-section measurements at ARRONAX facility for the production of (230)U [0.03%]
利用ARRONAX装置进行(232)Th(d,4n)(230)Pa反应截面测量以产生(230)U的研究
C Duchemin,A Guertin,F Haddad et al.
C Duchemin et al.
Introduction: (226)Th (T1/2=31 min) is a promising therapeutic radionuclide since results, published in 2009, showed that it induces leukemia cells death and activates apoptosis pathways with higher efficiencies than (213...
Biodistribution studies of two 18F-labeled pyridinylphenyl amides as subtype selective radioligands for the dopamine D3 receptor [0.03%]
两种标记的吡啶苯酰胺的生物分布研究作为多巴胺D3受体的亚型选择性放射配体
Carsten Hocke,Paul Cumming,Simone Maschauer et al.
Carsten Hocke et al.
Introduction: Dopamine D3 receptors are implicated in various neuropsychiatric diseases, drug abuse and alcoholism, but specific agents for D3 molecular imaging are lacking. We evaluated two in vitro selective fluorine-18...
[(18)F]-(fluoromethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)propan-2-ol ([(18)F FPTC) a novel PET-ligand for cerebral beta-adrenoceptors [0.03%]
新型的正电子发射断层成像（PET）配体[(18)F]氟代(FPMTC)及其对脑β肾上腺素受体的作用
Leila Mirfeizi,Anna A Rybczynska,Aren van Waarde et al.
Leila Mirfeizi et al.
Cerebral β-adrenergic receptors (β-ARs) play important roles in normal brain and changes of β-AR expression are associated with several neuropsychiatric illnesses. Given the high density of β-AR in several brain regions, quantification ...
Evaluation of a novel series of fluorine-18-labeled imidazobenzodiazepines as potential new positron emission tomography radioligands for the GABAA receptor [0.03%]
评价一系列新型氟-18标记的咪唑并苯二氮卓作为潜在的新的正电子发射断层成像GABAA受体放射配体的能力
Alexander Jackson,Mark R Battle,Dennis M O&#x;Shea et al.
Alexander Jackson et al.
Introduction: [(11)C]Flumazenil has been used to study the GABAA receptor in many preclinical and clinical studies, but the short half-life of carbon-11 means that this molecule is restricted to use by investigators with ...