Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging [0.03%]
一类新型放射性标记配体的合成及其作为5-HT7受体PET显像剂的药理学评价研究论文摘要
Julie Colomb,Guillaume Becker,Elsa Forcellini et al.
Julie Colomb et al.
Introduction: The brain serotonin-7 receptor (5-HT7) is the most recently discovered serotonin receptor. It is targeted by several drug-candidates in psychopharmacology and neuropharmacology. In these fields, positron emi...
Preparation of 99mTc-TRODAT-1 with high labeling yield in boiling water bath: a new formulation [0.03%]
一种新的制备高标记率99mTc-TRODAT-1的方法：沸水浴法
Mostafa Erfani,Mohammad Shafiei
Mostafa Erfani
A new formulation for preparation of (99m)Tc-labeled tropane derivative, (99m)Tc-TRODAT-1, which is useful as a potential CNS dopamine transporter imaging agent, was evaluated and characterized. Preparation of (99m)Tc-TRODAT-1 was attained ...
Production of 89Zr via the 89Y(p,n)89Zr reaction in aqueous solution: effect of solution composition on in-target chemistry [0.03%]
通过89Y（p，n）89Zr反应在溶液中生产89Zr：溶液组成对靶内化学的影响
Mukesh K Pandey,Hendrik P Engelbrecht,John P Byrne et al.
Mukesh K Pandey et al.
Objective: The existing solid target production method of radiometals requires high capital and operational expenditures, which limit the production of radiometals to the small fraction of cyclotron facilities that are eq...
Chuen-Yen Lau,Frank Maldarelli,William C Eckelman et al.
Chuen-Yen Lau et al.
The global battle against HIV-1 would benefit from a sensitive and specific radiopharmaceutical to localize HIV-infected cells. Ideally, this probe would be able to identify latently infected host cells containing replication competent HIV ...
¹²⁴I-Epidepride: a PET radiotracer for extended imaging of dopamine D2/D3 receptors [0.03%]
124I-埃皮德普利德：一种用于延长多巴胺D2/D3受体成像的PET放射示踪剂
Suresh Pandey,Archana Venugopal,Ritu Kant et al.
Suresh Pandey et al.
Objectives: A new radiotracer, ¹²⁴I-epidepride, has been developed for the imaging of dopamine D2/3 receptors (D2/3Rs). ¹²⁴I-Epidepride (half-life of ¹²⁴I=4.2 days) allows imaging over extended periods compared t...
Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging [0.03%]
64Cu-DOTA-AE105的体内剂量学研究及其作为PET影像剂用于uPAR成像的潜力评估
Morten Persson,Henrik H El Ali,Tina Binderup et al.
Morten Persson et al.
(64)Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish betwe...
166Ho and 90Y labeled 6D2 monoclonal antibody for targeted radiotherapy of melanoma: comparison with 188Re radiolabel [0.03%]
用于黑色素瘤靶向放射治疗的166霍和90钇标记单克隆抗体6D2与188铼标记物的比较研究
S Thompson,B Ballard,Z Jiang et al.
S Thompson et al.
Introduction: An approach to radioimmunotherapy (RIT) of metastatic melanoma is the targeting of melanin pigment with monoclonal antibodies (mAbs) to melanin radiolabeled with therapeutic radionuclides. The proof of princ...
Al18F-NODA-butyric acid: biological evaluation of a new PET renal radiotracer [0.03%]
新型肾PET显像剂Al18F-NODA-丁酸的生物评价研究
Malgorzata Lipowska,Jeffrey Klenc,Dinesh Shetty et al.
Malgorzata Lipowska et al.
Introduction: Renal scintigraphy is an important imaging modality for the diagnosis and management of a variety of renal diseases including obstruction and renovascular hypertension as well as the evaluation of absolute a...
Quantification of dopamine transporter density with [18F]FECNT PET in healthy humans [0.03%]
利用[18F]FECNT正电子发射断层扫描法定量检测健康人体多巴胺转运体密度
Jonathon A Nye,John R Votaw,J Douglas Bremner et al.
Jonathon A Nye et al.
Introduction: Fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane ([(18)F]FECNT) binds reversibly to the dopamine transporter (DAT) with high selectivity. [(18)F]FECNT has been used exten...
Biodistribution of a (67)Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag) [0.03%]
含细菌血清白蛋白结合域的抗TNF VHH单域抗体的镓-67放射性标记及其体内分布研究
Maurício Morais,Cátia Cantante,Lurdes Gano et al.
Maurício Morais et al.
Introduction: Small domain antibodies (sdAbs) present high potential for both molecular in vivo imaging and therapy. Owing to the low molecular weight they are rapidly cleared from blood circulation, and new strategies to...