Physical optimization of production by deuteron irradiation of high specific activity (177g)Lu suitable for radioimmunotherapy [0.03%]
用于放射免疫治疗的高比活度(177g)Lu的氘离子优化生产物理研究
Simone Manenti,Mauro L Bonardi,Luigi Gini et al.
Simone Manenti et al.
Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the grow...
PET quantification with a histogram derived total activity metric: superior quantitative consistency compared to total lesion glycolysis with absolute or relative SUV thresholds in phantoms and lung cancer patients [0.03%]
基于直方图的总活性度量的PET量化：与绝对或相对SUV阈值下的总的糖酵解相比，在体模和肺癌患者中具有更佳的定量一致性
Irene A Burger,Hebert Alberto Vargas,Aditya Apte et al.
Irene A Burger et al.
Introduction: The increasing use of molecular imaging probes as biomarkers in oncology emphasizes the need for robust and stable methods for quantifying tracer uptake in PET imaging. The primary motivation for this resear...
Holisoa Rajerison,François Guérard,Marie Mougin-Degraef et al.
Holisoa Rajerison et al.
Introduction: The clinical development of radioimmunotherapy with astatine-211 is limited by the lack of a stable radiolabeling method for antibody fragments. An astatinated N-heterocyclic carbene (NHC) Rhodium complex wa...
The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates [0.03%]
人类多核苷酸激酶/磷酸酶(hPNKP)抑制剂A12B4C3增强Auger电子发射抗人白血病药物的效果
Arman Zereshkian,Jeffrey V Leyton,Zhongli Cai et al.
Arman Zereshkian et al.
Introduction: Leukemia stem cells (LSCs) are believed to be responsible for initiating and propagating acute myeloid leukemia (AML) and for causing relapse after treatment. Radioimmunotherapy (RIT) targeting these cells m...
Carbon-11 labeled cathepsin K inhibitors: syntheses and preliminary in vivo evaluation [0.03%]
用于标记猫冬蛋白K抑制剂的碳-11：合成与初步体内评价
Melissa E Rodnick,Xia Shao,Kenneth M Kozloff et al.
Melissa E Rodnick et al.
Cathepsin K is a cysteine peptidase primarily located in osteoclasts, cells involved in normal growth and remodeling of bone but that are also responsible for bone loss in osteolytic diseases such as osteoporosis. In vivo imaging of catheps...
Peptide synthesis, characterization and ⁶⁸Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT [0.03%]
用于正电子发射断层扫描/计算机断层成像感染显像的NOTA连接乌比西丁片段的肽合成、表征和68镓标记研究
Thomas Ebenhan,Nicholas Chadwick,Mike M Sathekge et al.
Thomas Ebenhan et al.
Introduction: Human antimicrobial peptides are of interest for the development of positron emission tomography (PET) tracers as they exhibit desirable characteristics that make them good candidates for targeting vectors. ...
DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy [0.03%]
低剂量率Auger放射免疫治疗期间有效激活DNA损伤中心信号通路
Bérengère Piron,Salomé Paillas,Vincent Boudousq et al.
Bérengère Piron et al.
Introduction: Low dose-rate radioimmunotherapy (RIT) using (125)I-labelled monoclonal antibodies ((125)I-mAbs) is associated with unexpected high cytotoxicity per Gy. ...
Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A [0.03%]
人源性肝干细胞经门静脉输注后的分布：一型糖原累积病患者17年观察结果
Florence Defresne,Tatiana Tondreau,Xavier Stéphenne et al.
Florence Defresne et al.
Introduction: Current treatment of inherited liver inborn errors of metabolism in children consists in appropriate diet and drugs and, for unstable patients, final orthotopic liver transplantation. Unfortunately, liver tr...
Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates [0.03%]
非人灵长类动物中的PDE10A选择性正电子发射断层扫描示踪剂[11C]AMG 7980的初步特征分析
Dah-Ren Hwang,Essa Hu,Shannon Rumfelt et al.
Dah-Ren Hwang et al.
Introduction: Phosphodiesterase 10A (PDE10A) is an intracellular enzyme responsible for the breakdown of cyclic nucleotides which are important secondary messengers in the central nervous system. Inhibition of PDE10A has ...
Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan [0.03%]
99mTc-N-戊氧基-5-甲基色氨酸临床肝胆显像的肝脏摄取和胆汁排泄转运机制研究
Masato Kobayashi,Takeo Nakanishi,Kodai Nishi et al.
Masato Kobayashi et al.
Introduction: In clinical hepatobiliary scintigraphy, (99m)Tc-N-pyridoxyl-5-methyltryptophan ((99m)Tc-PMT) is an effective radiotracer among the (99m)Tc-pyridoxylaminates. However, the mechanisms of human hepatic uptake a...